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Biomedical subjects

C Eggers

Publications and source records attributed to C Eggers.

At least 19 recordsLinked to original sources
PubMed1992

Determination of valproic acid by high-performance liquid chromatography with photodiode-array and fluorescence detection.

The derivatization of valproic acid and undecylenic acid with 4-bromomethyl-7-methoxycoumarin is described. The derivatives were detected by photodiode-array and fluorescence detectors. The optimum monitoring conditions and the stability of the suspension solution and derivatives were investigated. A high-performance liquid chromatographic (HPLC) method with isocratic or gradient elution has been established for the analysis. This method has been used for the determination of total and free valproic acid in serum. There is a satisfactory correlation between the results obtained by this HPLC method and those measured by the enzyme immunoassay. Some other common anti-epileptic drugs did not interfere with the analysis. The method is simple and fast and has better sensitivity and linearity than enzyme immunoassay. It is suited for routine therapeutic drug monitoring.

Chromatography, High Pressure Liquid↗
PubMed1992

Paranoid schizophrenics may not use irrelevant signals. The use of measures of blocking and of urinary dopamine.

Conditioned blocking tests for the use of superfluous (irrelevant) information in task-solving. Paranoid psychotic, obsessive-compulsive and healthy subjects usually showed normal blocking, but non-paranoid subjects tended to learn about the superfluous stimulus. Attenuated blocking was usually associated with increased dopamine utilization measured in 24h urine samples. This may reflect poor stabilization of response to neuroleptic medication.

Adolescent↗
PubMed1989

Schizo-affective psychoses in childhood: a follow-up study.

A follow-up study of 16 schizo-affectives (part of a group of 57 children originally diagnosed as schizophrenic) is reported. All 57 patients were under 14 years. They were reinvestigated after an average follow-up period of 16 years (range 6 to 40 years). Of the 57 psychoses 28% had a typical schizo-affective character. In contrast to purely schizophrenic psychoses, we found an overrepresentation in the schizo-affective psychoses of affective psychoses and suicides in the ancestry. Further, in the schizo-affective psychoses there were more premorbidly well adjusted, harmonious personalities. In contrast, maladjusted, dishormonious, introverted characters predominated in purely schizophrenic psychoses. The schizo-affective psychoses had mainly an acute-recurrent character and followed a favorable course. The schizo-affective and affective phases were of significantly shorter duration than the schizophrenic episodes.

Adolescent↗
PubMed1988

Clinical and neurobiological findings in children suffering from tic disease following treatment with tiapride.

Tiapride, a substituted benzamide derivative, possesses good clinical antidyskinetic properties due to its DA2-blocking activities. It has been shown to be clinically effective in the treatment of tic disease in children. In order to study tiapride's antidyskinetic properties in the treatment of the tic syndrome in children, we conducted a simple, placebo-controlled study on 10 children followed by a double-blind crossover study on 17 children. Tiapride was shown to have a positive therapeutic effect on tics in children; whereas it has no adverse effects on neuropsychologically measurable cognitive performances in children. Neurophysiological parameters such as the EEG frequency analysis and sensory evoked potentials were not affected by tiapride, nor was the neurosecretory, hypothalamic-hypophyseal regulation of the sex hormones, thyroid stimulating hormone, growth hormone, or thyroid hormone impaired. The hyperprolactinemia caused by tiapride's dopaminergic properties was moderate and restricted to the duration of therapy.

Adolescent↗
PubMed1988

[Pediatric depression].

In 12 children between 6 and 12 years of age who were treated as inpatients for depression (diagnosed according to the Weinberg-criteria, a child-adapted modification of DSM-III-criteria), a close relationship was found between family pathology, psychodynamics and depression. The conflicts in the interactions between the depressed children and their caregivers became evident in the children's drawings, in the Scenotest and in play therapy. In play therapy the repressed feelings of powerlessness, helplessness, disappointment, resignation and anger came to light. The children had a pseudo-stabilizing function in the family that placed too heavy demands on them, with the result that they became dependent and helpless and tended to despair. A situation developed that can be characterized as "learned helplessness" and that is a useful behavioral-physiological and neurobiological model of depression for different age groups.

Child↗
PubMed1986

[Autologous spongiosaplasty in the treatment of chronic osteomyelitis].

The most promising method of filling up osteomyelitic bone deficiencies is the transplantation of fresh autologous spongiosa as soon as the infection is under control. The fundamental principles of surgical therapy of septic focuses must not be neglected. A spongiosa graft into the florid infection has only little chances of success. The stability of the deficiency is decisive for the success of the transplantation. In case of infection it is necessary as far as possible to choose a point remote from the septic focus for the grafting of the osteosynthetic material.

Adult↗
PubMed1986

[Regression trends of neurologic damage in the surgical emergency management of patients with injuries of the cervical vertebrae with spinal cord involvement].

Sixty-five patients with cervical spine injuries and varied neurological deficits were treated operatively. Evaluation revealed an improvement in neurological findings dependent upon the promptness of anatomical reduction in patients with incomplete lesions. The more frequent neurological improvement seen with open reduction and internal fixation as compared with closed reduction was not statistically significant but was felt to justify the additional resources required for internal fixation. In complete lesions, there was no evidence that the time of anatomical reduction was related to improvement in neurological findings.

Adult↗
PubMed1978

Course and prognosis of childhood schizophrenia.

Follow-up data on 57 schizophrenic patients, including 25 boys and 32 girls between the ages of 7 and 13, is reported. Average length of follow-up was 15 years. Symptoms found in children under 10 and in prepubertal cases are described. Cases with acute, relapsing episodes occurred more often than chronic cases, but before age 11 acute cases were less frequent. Twenty percent of the patients recovered completely, 30% reached a relatively good social adjustment, and 50% had moderate or poor remission. Family incidence of psychiatric disorders had no influence on prognosis, nor did unfavorable family environment. Premorbid personality development was, however, found to be of prognostic value. Prodromal episodes occurred in 55% of the cases, and 65% of the patients were preoccupied by death. Additional follow-up findings are presented, and problems of diagnosis are discussed.

Adolescent↗