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Biomedical subjects

C Edouard

Publications and source records attributed to C Edouard.

60 records · Page 4Linked to original sources
PubMedDate not supplied

[Histomorphometric and biological data on osteoporosis due to immobilization].

The effect on the bones of immobilization was studied by means of quantitative histological methods on 34 biopsies of the iliac crest after different periods of immobilization in 28 patients, 22 of whom were immobilized by medullary lesions. At the same time a biochemical study was carried out on 68 immobilized patients over a 52-week period. This histomorphometric study included measurements of the absolute volume of trabecular bone, the volume of the osteoid matrix, the osteoclastic resorption surfaces, the size of the osteocyte lacunae, the thickness of the iliac cortical zones and the medullary adipose volume. 19 subjects received in addition double labeling with tetracycline with the object of carrying out a histodynamic study of the osteoblastic activity. The decrease in the absolute volume of the trabecular bone reached 33 percent of its original value and continued up to the 25th week, and was followed by stabilization at a value slightly higher than the vertebral fracture limit. Immobilization also led to an increase in the osteoclastic resorption surfaces and, secondarily, to an increase in the periosteocyte lacunae, a thinning of the iliac cortical zones, and a decrease in the volume of the osteoid matrix. Calciura increased as did total hydroxyprolinuria in parallel with an increase in the resorption surfaces. The histological and biochemical changes suggest a histodynamic hypothesis, according to which the longevity of the basic multicellular bone unit increases, leading to a new equilibrium characterized by very slow renewal of the bone.

Adult↗
PubMedDate not supplied

[Efficacy of x-ray computed tomography in the diagnosis of tumors of the mediastinum. 103 cases].

A prospective study was carried out in 103 patients with mediastinal tumors to determine diagnostic value of CT imaging. A precise diagnosis was obtained in 80% of cases, the detection sensitivity being 100%, 98% and 71% respectively for fatty tumors (20 cases), solid tumors (59 cases) and cystic tumors (24 cases). The weak sensitivity of detection of cystic tumors was due to the spontaneously elevated density of mediastinal cystic tumors and the fact that 2 patients in this series with cystic lesions presented enhanced images with contrast. Sensitivity of detection of a malignant tumor was only 59%, due mainly for thymic tumors to extracapsular microscopic extensions undetected by CT scanning, which should however be included in exploratory techniques for mediastinal tumors.

Humans↗