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Biomedical subjects

C E van Rooyen

Publications and source records attributed to C E van Rooyen.

9 recordsLinked to original sources
PubMed1983

Three to eight weeks of therapy with netilmicin: toxicity in normal and diabetic patients.

Twenty-eight patients, 24 men and 4 women, aged between 17 and 72 years old, and suffering from chronic osteomyelitis (19), mastoiditis (5), or serious wound infections (4) were treated for an average of 35 days with netilmicin at doses of 2.4 to 6.9 mg/kg/day. The total dose of netilmicin given to each patient ranged from 3700 to 23 220 mg. Although the renal function was initially normal in all patients and stayed normal throughout therapy in all patients with no underlying disease, netilmicin nephrotoxicity was detected in two diabetic patients (7.6%). Vestibular toxicity developed in two (7.6%) but no change in audiograms was noted. Long-term therapy was associated with a significant increase (P less than 0.001) in half-life, from 1.5 to 1.9 h, and AUC 7.9 to 13.1 mg/l/h.

Adult↗
PubMed1974

Prosthetic valvular endocarditis due to the fungus Paecilomyces.

The third reported case of prosthetic valvular endocarditis caused by the fungus Paecilomyces is presented. The clinical course of the patient is discussed. The distinctive morphology of the fungus is described, together with the histologic and cytologic features found in the excised prosthetic valve and in the tissues at autopsy. Prosthetic valvular endocarditis presents a serious antibiotic and surgical problem in therapy. Despite antifungal antibiotics and valve replacement this patient died as a result of metastatic cerebral microabscesses and subarachnoid hemorrhage.

Amphotericin B↗
PubMed1974

Streptococcus bovis endocarditis.

A case is described of bacterial endocarditis caused by Lancefield group D Streptococcus bovis. Because of its sensitivity to the less toxic antibiotics such as penicillin, the importance of laboratory differentiation from the more resistant enterococci is emphasized. Treatment in this case was complicated by penicillin allergy and cardiac failure. The condition finally responded to clindamycin therapy and aortic valve replacement.

Aortic Valve Insufficiency↗
PubMed1969

Prevalence of cytomegalovirus infection in a normal urban population in Nova Scotia.

During 1967 and 1968 a seroepidemiological survey was conducted on the prevalence of CF antibodies to CMV in the normal population of the Halifax-Dartmouth metropolitan area of Nova Scotia. Samples of 550 sera, collected from all age groups, including newborns, were processed. At birth, 34% of infants possess antibodies, presumably of maternal origin, and there follows a decline until at 2 years of age only 4% of children exhibit evidence of infection. There is a gradual increase up to 16% by 20 years of age, and thereafter this is maintained until by 40+ years half the population possesses antibodies.A more detailed analysis of cord sera indicated that approximately 60% of women of childbearing age possess no antibodies and are susceptible to primary CMV infection. Among these, age and gravidity are not significant factors.These data indicate that CMV infection is fairly widespread in this community, although comparative studies suggest that it is less so than in some other areas, such as Easter Island, where a more homogeneous pattern of overcrowding and poor sacioeconomic conditions prevails.

Adolescent↗