Search PubMed⌕ Search

Biomedical subjects

C E Wells

Publications and source records attributed to C E Wells.

At least 19 recordsLinked to original sources
PubMed1991

The gene organisation of the human beta 2 integrin subunit (CD18).

We have studied the gene of the human beta 2 integrin subunit (CD18) and found it to be organised into 16 exons spanning a region of about 40 kb. All exon/intron boundaries conform to the GT/AG splicing consensus. The exons coding for the cysteine-rich region, which has been postulated to consist of 3 or 4 repeating elements, are not organised correspondingly. Transcription of the gene initiates from multiple sites which may be due to the absence of an upstream TATA box. The polyadenylation site is also heterogeneous. Five different sites were identified over a stretch of 10 bases.

Amino Acid Sequence↗
PubMed1979

Pseudodementia.

Pseudodementia is the syndrome in which dementia is mimicked or caricatured by functional psychiatric disorders. The author describes 10 patients with pseudodementia and compares its clinical features with those of true dementia. The syndrome occurred in patients with various psychiatric diagnoses, but a striking feature in most patients was marked dependency. The recognition of this clinical syndrome should obviate the need for many neurological diagnostic studies and lead to earlier and more effective psychiatric treatment.

Aged↗
PubMed1979

Management of dementias.

Our best hope of helping patients who appear to be demented lies in the painstaking diagnostic evaluation of each such patient whom the physician encounters. The first step is to separate out those patients who appear to have organic dementias but in fact do not. These pseudodemented patients, i.e., patients with functional psychiatric disorders mimicking dementia, often have an excellent prognosis. Next, in those patients with diffuse organic dysfunction, a diligent search must be made for those disorders that are amenable to specific therapy. Good evidence is available to demonstrate that thorough diagnostic evaluation pays off in the identification of a significant proportion of treatable disease. Even when no treatable disease can be identified, treatment of coexisting medical and physical problems, environmental manipulation, and pharmacologic therapy can do much to alleviate the patient's plight.

Adult↗
PubMed1979

Manic psychosis in a patient with multiple metastatic brain tumors.

A 45-year-old man, with neither previous psychiatric dysfunction nor a family history of manic-depressive illness, developed a manic psychosis coincident with the growth of 4 metastatic tumors in the right cerebral hemisphere. The psychosis responded well to treatment with lithium even though the metastatic lesions could not by eradicated with surgery or radiation.

Adenocarcinoma↗
PubMed1979

A paired controlled study of vaginal and abdominal delivery of the low birth weight breech fetus.

In a paired, controlled, retrospective study, 44 low birth weight breech fetuses delivered vaginally were compared with 44 breech fetuses delivered by cesarean section. Seven deaths occurred in the vaginal delivery group, compared with only 1 in the abdominal delivery group. Asphyxia, trauma, and intracranial hemorrhage were also found more frequently among vaginally delivered fetuses. The authors conclude that for the low birth weight breech fetus, delivery by cesarean section is preferable.

Asphyxia Neonatorum↗
PubMed1979

Case studies in neuropsychiaatry. II: Conversion pseudodementia.

A patient is described who experienced pseudodementia as a conversion reaction. The patient was considered to be demented originally because of the evidence for profound cognitive impairment elicited on mental state examination. Careful analysis of the patient's verbal production in unstructured situations and of her behavior inthe hospital permitted a clinical diagnosis of pseudodementia to be made, a diagnosis confirmed by response to treatment and long term follow-up. Evidence is presented to support the interpretation of her pseudodementia as a conversion reaction.

Adult↗
PubMed1978

Chronic brain disease: an overview.

The author discusses the current state of clinical and pathological knowledge regarding chronic brain disease, focusing particularly on the dementias. His review of clinical studies deals with diagnostic issues and methods, etiology, and treatment. More basic research on brain alterations with aging, their relation to clinical manifestations of dementia, and studies of specific disorders are also reviewed. These disorders have been receiving increasing attention from psychiatrists, who are becoming more aware of the importance of organic cerebral factors in their patients' complaints. The need to understand the chronic brain diseases and their appropriate diagnosis and treatment will continue to grow as the proportion of older individuals in our society increases.

Aging↗
PubMed1977

Leuco-erythroblastosis following withdrawal from glucocorticoid therapy.

Leuco-erythroblastosis has many known associations (Burkett, Cox and Fields, 1965; Weick, Hagedorn and Linman, 1974; Retief, 1964), but the only ones related to drug therapy are the well established response to haematinics (Burkett et al., 1965) and one possible case following anti-epileptic therapy (Retief, 1964). The case described below is of leuco-erythroblastosis following steroid withdrawal in a young man with primary polymyositis.

Adult↗
PubMed1977

Hallucinations as a conversion reaction.

This clinical report describes a patient who experienced complex visual and auditory hallucinations as a conversion reaction. The evidence suggests that hallucinations as a conversion reaction are qualitatively different from other types of hallucinations.

Adolescent↗
PubMed1976

A thrice-told tale of therapy.

A case history twice discussed previously in the literature is reexamined. The patient probably suffered a manic-depressive illness, and remission, therefore, is not specifically attributable to psychotherapy. The significance of psychotherapy in the patient's treatment is argued, but for its supportive, not its curative, effects.

Adult↗
PubMed1976

A membrane-associated autoantibody in a case of myasthenia gravis with chronic hepatitis.

A new antibody reacting with a cell membrane-related antigen is described in a patient with myasthenia gravis and chronic liver disease. The antibody gave a striking peripheral immunofluorescence in all cells tested and did not react with smooth muscle fibres, being distinct from anti-actin and anti-myosin antibodies. The antigen was widely distributed in human and animal tissues. The exact relationship of this antibody to the clinical condition is not obvious but its presence is further evidence of widespread disturbances of humoral immunity in myasthenia gravis.

Autoantibodies↗