Search PubMed⌕ Search

Biomedical subjects

C E Tomich

Publications and source records attributed to C E Tomich.

At least 37 records · Page 2Linked to original sources
PubMed1988

Embryonal rhabdomyosarcoma arising in the masseter muscle as a second malignant neoplasm.

A case is reported about a patient who was originally treated for bilateral retinoblastoma and subsequently developed an embryonal rhabdomyosarcoma in the masseter. Such patients have a genetic predisposition to a second malignancy that statistically far exceeds the rate for the general population. In addition, current treatment methods also increase the patient's susceptibility to another malignancy. This case emphasizes the necessity of maintaining a high degree of clinical suspicion in the evaluation of any lesion that may appear subsequent to the treatment of cancer in children, particularly bilateral retinoblastoma.

Child↗
PubMed1987

Statistical analysis of clinical, radiographic, and histologic features of temporomandibular arthropathy.

For a variety of reasons, the past few years have brought about a tremendous emphasis on conditions affecting the temporomandibular joint and associated structures. Although important advances are being made relative to the diagnosis and treatment of these conditions, a myriad of problems remain for the practitioner who tries to sort through the literature or who attends courses in order to determine a means for properly diagnosing and treating these patients. This article attempts to develop correlations between certain clinical and radiographic findings documented by histologic evaluation as a beginning guide to more sound diagnosis.

Diagnosis, Differential↗
PubMed1987

Immunoprofile of benign and malignant fibrohistiocytic tumors.

Formalin-fixed, paraffin-embedded tissue sections from 26 malignant fibrous histiocytomas (MFH) and 61 benign fibrohistiocytic proliferations (BFHP) were evaluated immunohistochemically. An avidinbiotin-peroxidase technique was used to determine immunoreactivity for alpha-1 antichymotrypsin, muramidase, HLA-DR, leucocyte common antigen, S-100 protein, vimentin, desmin, and keratin. MFHs were consistently positive for ACT and vimentin and inconsistently reactive for the other antigens. MFHs were negative for LCA suggesting a mesenchymal origin for these lesions. In the MFH histologic subtypes, antigen expression was not significantly different to be useful in their classification. Also no distinctive pattern emerged relative to immunoreactivity and tumor location. The benign lesions, giant cell tumor of tendon sheath, dermatofibroma, and oral benign fibrous histiocytoma differed from the MFHs in that they were often LCA positive, suggesting origin from hematopoetic mononuclear-macrophages. The immunoprofiles of peripheral fibromas and "giant cell" fibromas were felt to be consistent with origin from mesenchymal cells. Several of the antigens studied could be used to differentiate the benign lesions studied from other benign neoplasms. The antigens were, however, of little value in separation of benign and malignant lesions.

Adolescent↗
PubMed1985

Effects of nicotine-containing chewing gum on oral soft and hard tissues: A clinical study.

A double-blind clinical trial was conducted to determine whether the use of a chewing gum containing 2.0 mg nicotine (as an adjunct to a stop-smoking program) had any effects upon oral health. A total of 193 adults who smoked cigarettes volunteered with informed consent, were given routine dental prophylaxes, and were examined for the presence of plaque, stained pellicle, gingivitis, calculus, and general oral pathosis. The subjects were then randomly assigned to use either a nicotine-containing or a placebo chewing gum. After 15 weeks the subjects were recalled and re-examined. Smoking cessation was determined through questionnaire and analysis of the carbon monoxide content of alveolar air. At the completion of the study, 79 subjects had used the placebo gum and 78 had used the nicotine gum. Data analysis indicated that the nicotine chewing gum had no significant influence on any of the oral health parameters graded, as compared to the placebo gum. The continuation of smoking, however, was associated with significant increases in gingivitis and calculus rates.

Carbon Dioxide↗
PubMed1980

Treatment of phenytoin-induced gingival hyperplasia by electrosurgery.

Many medications and combinations of medications are available for the control of epilepsy, but phenytoin continues to be the most effective agent for most patients. A common side effect of this drug is the development of moderate to severe gingival hyperplasia in tooth-bearing areas, which can contribute to problems of function, oral hygiene, appearance, and, eventually, loss of teeth. Excision by conventional means is technically difficult, time-consuming, may be associated with considerable loss of blood, and requires postoperative care, such as periodontal packing, that is impractical if not impossible for many patients, especially the severely mentally handicapped. We have described a technique of gingivectomy using an electrosurgical device in the hospital with the patient under general anesthesia that has produced good results for more than 15 years. This procedure has virtually eliminated the problems of conventional surgical excision with little or no postoperative sequelae.

Connective Tissue↗
PubMed1976

Palisaded, encapsulated neuroma of the lip.

A case of palisaded, encapsulated neuroma of the lower lip has been presented. To the best of our knowledge, this is the first reported instance in the dental literature. The lesion characteristically occurs on the skin of the face near the oral, nasal, and orbital mucocutaneous junctions and, therefore, is readily visible to the oral diagnostician. It occurs most often in middle-aged individuals and, although it may clinically mimic other lesions, the operative finding of an easily enucleated mass near a mucocutaneous junction should suggest this lesion in the differential diagnosis. Histologically, the lesion is characterized by three distinct zones--an outer compressed fibrous connective tissue capsule, an inner myxomatous zone, and a central zone of proliferating Schwann's cells arranged in interlacing fascicles with areas of palisaded cells and organoid structures. The lesion is treated by enucleation or excision and has no tendency to recur.

Humans↗
PubMed1976

Chondroma of the anterior nasal spine.

Chondromas in the head and neck, and particularly in the nasal region, are uncommon. A unique case of a chondroma within the anterior nasal spine has been reported. The asymptomatic lesion was discovered radiographically and mimicked a mesiodens. The tumor consisted of benign-appearing cartilaginous tissue; enucleation has resulted in a apparent cure. A hamartomatous origin has been postulated for this unusual lesion.

Adult↗
PubMed1976

Synovial sarcoma of the neck: report of case.

Synovial sarcoma is an uncommon neoplasm that usually arises in the extremities and rarely in the head and neck. A case arising in the neck has been reported herein. The tumor is composed of two intimately associated cellular patterns; one resembles synovial structures and the other resembles fibrosarcoma. The tumor is fairly slow growing and is fairly well circumscribed but not actually encapsulated. There is a predilection for males; most occur in the third through fifth decades of life. Recurrence follows inadequate therapy. Although local excision was the therapy used in this case, the patient is alive and free of disease 30 months postoperatively.

Adult↗
PubMed1975

Lymphoproliferative disease of the hard palate: a clinicopathologic entity. A study of twenty-one cases.

Twenty-one cases of a lymphoproliferative disorder believed to represent a clinico-pathologic entity were studied. These lesions, which appeared on the hard palate, occurred in elderly men and women with an average age of 70 years. The lesions presented as soft, fluctuant swellings which were occasionally bilateral, ulcerated, or discolored. Microscopically, the lesions were classified as lymphocytic lymphomas; eight were diffuse and well differentiated, seven were nodular and well differentiated, and six were diffuse and poorly differentiated. All lesions were characterized by a tendency of the lymphocytes to show nuclear fragility. Accessory salivary gland involvement was common, this being characterized by acinar obliteration to varying degrees and by periductal hyalinization of collagen. Determinate follow-up of fourteen patients disclosed that eight died of disseminated lymphoma, three are alive with disease, and three are free of disease after treatment with radiation and/or chemotherapy. Lymphoproliferative lesions in this location are believed to be malignant or potentially malignant processes.

Cysts↗