Search PubMed⌕ Search

Biomedical subjects

C E Stewart

Publications and source records attributed to C E Stewart.

46 records · Page 3Linked to original sources
PubMed1977

A manual system for storage and inventory control of laboratory supplies.

The demand for laboratory supplies has increased in relation to the increase in the quantity and complexity of the laboratory workload. This has created many problems for the laboratory administration and a major one has been the lack of a good system for storage and inventory control of supplies. This paper presents a manual system for such control and suggests the use of two different control procedures.

Laboratories↗
PubMedDate not supplied

Adaptations of the IGF system during malignancy: human skeletal muscle versus the systemic environment.

Presented in this study are data derived from a unique cohort of patients both with and without cancer, for whom we not only have serum samples, allowing us to investigate systemic factors impacting on skeletal muscle maintenance, but also primary skeletal muscle cultures giving us a model to mimic the in vivo muscle milieu. Possible local effects of autocrine/paracrine and endocrine IGF system components impacting on myoblast growth and differentiation could therefore be assessed. We report for the first time that the decrease in myoblast stem cell numbers seen with normal aging is lost in cancer patients. We further report that serum IGF-I, IGF-II and IGFBP-3 all show positive correlations with myoblast retrieval in control patients, but that with the exception of IGFBP-3 these correlations are lost in malignancy. Indeed IGF-II switches to a negative correlation with myotube formation in malignancy. Furthermore we provide initial evidence to suggest that there is an apparent altered regulation of local IGFBP-3 production during malignancy which may enable satellite cell proliferation, stem cell infiltration or both. Finally we show the importance of investigations not only monitoring the systemic impact of serum factors on skeletal muscle responses but also critically assessing the role that locally produced muscle IGFBP-3 may have on the systemic environment.

Adult↗
PubMedDate not supplied

Computed tomography of local complications of temporal bone cholesteatomas.

The preoperative temporal bone CT scans of 13 patients with surgically proven acquired cholesteatoma were retrospectively reviewed for bony erosions and for extension beyond the temporal bone. A correlation with the clinical and surgical findings was also carried out. The CT findings are discussed and illustrated as well as some pitfalls in the evaluation of bony erosions. The appearance of "autoantrectomy" caused by a dry, self-cleaning, well ventilated cholesteatoma is also discussed and illustrated.

Adolescent↗