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Biomedical subjects

C E Reed

Publications and source records attributed to C E Reed.

At least 199 records · Page 11Linked to original sources
PubMed1976

Use of an inhibitor-resistant live attenuated influenza vaccine in normal and asthmatic adults.

The efficacy of a monovalent live attenuated influenza A (H3N2) vaccine (an inhibitor-resistant recombinant strain named "Alice") and of a bivalent vaccine composed of "Alice" and influenza B strain R75 (also inhibitor-resistant), was tested in healthy and asthmatic adults. Two intranasal doses of the monovalent "Alice" vaccine were given to 95 healthy adults in the winter of 1973-74. Ninety-three % of 68 subjects with initial serum hemagglutination (HI) titers of less than or equal to 1:40 had a significant (4-fold or greater) antibody increase in post-vaccination sera. Overall, 77% of the vaccinees had significant antibody rises. Two doses of the bivalent (A/B) vaccine were given to 53 healthy adults in the winter of 1974-75. Eighty-two % of 34 subjects with initial HI titers of less than or equal to 1:40 had 4-fold or greater antibody rises to influenza A, and overall 57% of the vaccinees responded. The B component of the bivalent vaccine was less effective; only 56% of persons with initial HI titers of less than or equal to 1:40, and 28% of all vaccinees had significant antibody rises. Both tf asthmatics who received "Alice" and one of 10 (10%) who received the bivalent vaccine had serologic responses to influenza A. None of the asthmatics responded to the B component of the bivalent vaccine. Analysis of the incidence of febrile respiratory illness during an influenza outbreak in the winter of 1974-75 revealed no differences in the attack rates of placebos and vaccines. In conclusion, both the "Alice" and bivalnet (A/B) vaccines were effective in eliciting serologic responses to influenza A in healthy persons. They were less effective in asthmatics. The lack of protection observed may have been due to the onset of influenza before the vaccine could take effect or to the failure of the vaccine itself.

Administration, Intranasal↗
PubMed1975

Immunotherapy in bee-sting anaphylaxis. Use of honeybee venom.

After nine months of immunotherapy with commercially prepared wholebody bee extract, a beekeeper's wife experienced anaphylaxis after a controlled bee-sting challenge. High risk of future bee stings prompted a decision to attempt desensitization with honeybee venom. This was extracted from the bee into Coca solution and administered parenterally in increasing daily doses until an equivalent of one venom sac was given per day. This maintenance dosage was continued for a month. Anaphylaxis did not occur after another bee-sting challenge. Therapy has been maintained with venom. With this treatment, there has been an increase in the level of IgG-blocking antibody and a fall in IgE titer to bee venom (radioallergosorbent test [RAST]).

Adult↗
PubMed1975

Precipitating antibodies in office workers and hospitalized patients directed toward antigens causing hypersensitivity pneumonitis.

The frequency of precipitating antibodies to Aspergillus, thermophilic actinomycetes, and pigeon serum was studied in hospitalized patients and in employees of the state of Wisconsin. Precipitins to Aspergillus were detected in 9 per cent of the hospitalized patients and 3 per cent of the state employees. The majority of the serologically reactive hospitalized patients were diagnosed as having carcinoma with metastases, lymphoma, or leukemia. No evidence of hypersensitivity pneumonitis or invasive aspergillosis was seen in these patients. The frequency of antibodies to thermophilic actinomycetes (3 per cent) and pigeon serum (1 per cent) was similar in both groups. Women from 17 to 25 years of age and men from 52 to 66 years of age demonstrated an increased incidence of positive precipitins.

Adolescent↗
PubMed1975

Aerosol Sch 1000. An anticholinergic bronchodilator.

Atropine is known to be an effective bonrchodilator. We studied the effectiveness of aerosol Sch 1000, a derivative of atropine, in relieving bronchoconstriction in asthma. A single dose of drug was effective within 5 min, and the effect had a duration of 4 hours. No side effects were noted. The major effect of the drug appeared to be in large airways.

Adolescent↗
PubMed1975

N-acetyl-beta-glucosaminidase activity in normal and malignant leukocytes.

An improved cytochemical method demonstrating N-acetyl-beta-glucosaminidase in peripheral blood and bone marrow leukocytes is described. A significant elevation in enzyme activity in circulating monocytes from patients with solid tumor malignancies was observed. In a large series of cases of acute nonlymphocytic leukemia, elevated levels were found in the vast majority of those leukemias that had a predominant monocytic component identified either morphologically or by standard cytochemical methods. This reaction would appear to be useful as a monocyte marker.

Acetylglucosaminidase↗
PubMed1974

Farmer's lung.

Explore the source record for details and available documents.

Actinomycetales Infections↗
PubMed1974

Greater frequency of viral respiratory infections in asthmatic children as compared with their nonasthmatic siblings.

A longitudinal clincal and microbiologic surveillance was conducted from October to May, 1971-72, on 16 children with infectious asthma and 15 of their nonasthmatic siblings. Asthmatic children experienced a significantly greater frequency of viral respiratory infections than did nonasthmatic ones (5.1 vs. 3.8 per subject). This increased incidence appeared to be largely the result of a greater number of rhinovirus infections. While respiratory infections of identical etiology that occurred concurrently in an asthmatic and his sibling were equivalent in severity, illnesses were longer (but not significantly so) in asthmatic children.

Asthma↗