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Biomedical subjects

C E Polkey

Publications and source records attributed to C E Polkey.

132 records · Page 8Linked to original sources
PubMed1980

Self-report of memory skills after temporal lobectomy: the effect of clinical variables.

Forty-eight patients who had undergone unilateral temporal lobectomy for the relief of focal epilepsy 6 months to 6 years prior to contact were asked to rate themselves on a questionnaire designed to look at "real-life" memory skills. The temporal lobe patients, as a group, saw themselves as having poorer memories than normals, but only 3 out of 43 items showed significant differences between right-and left-sided lobectomy patients. Our hypotheses that age at operation, reduction in seizure frequency and time since operation (in the left temporal lobe patients only) would determine the extent of subject complaint of memory were fully confirmed. In addition, sex of the patient was found to be a significant variable. The status of subjective and objective measures of memory as indices of "real-life" memory skills is discussed.

Adult↗
PubMed1979

Electrical splinting of the knee in paraplegia.

Two men with T7 and T12 complete traumatic lesions have received implants to stimulate the femoral nerves and (in the T7 case) the inferior and superior gluteal nerves. By using these continuously at 13 pulses/sec they can stand and walk, as other paraplegics do with calipers. Regular stimulation at 11 or 13 pulses/sec greatly increases the force exerted by the quadriceps femoris muscles and their resistance to fatigue, and this improvement is not lost during 2 months without stimulation.

Adult↗
PubMed1975

Kinetic properties of hexokinase in resected temporal lobes of patients with drug-resistant epilepsy.

Properties of the cerebral glycolytic enzyme, hexokinase, were studied in biopsy samples of human temporal lobe, obtained during lobectomy for drug-resistant epilepsy and compared "blind" with contol biopsy samples of human cerebral cortex. No significant changes in the total activity or subcellular distribution of the enzyme were observed but the Km value for glucose was altered. The 17 control samples gave a normal mean value for Km (glucose) of 0.05 mM and the 14 epileptic samples gave a significantly higher mean value of 0.09 mM. The drugs used in previous treatment of the epilepsies were "scored" with respect to type and dose; analysis of these in relation to the kinetic results eliminated the possibility that the increase in Km value was an artifact due to the drugs. The observed change in enzyme kinetic properties is discussed in terms of potential interactions of small molecules with the isoenzymes of cerebral hexokinase.

Age Factors↗