Serial EEG studies in centrencephalic epilepsy in children born prematurely.
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Adolescent↗
Biomedical subjects
C E Petersen
Publications and source records attributed to C E Petersen.
Introduction and general description of the study and of the procedures for prolonged exposure to carbon monoxide and hypoxia.
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Adult↗
[Electroencephalographic studies on the genetics of spasmophilia of the centrencephalic type].
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Adolescent↗
[Fever cramps and epilepsy. I. Etiology, clinical picture and course of the so-called infection or fever cramps].
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Adolescent↗
[Fever cramps and epilepsy. II. Electroencephalographic study of the course of so-called fever or infection cramps].
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Adolescent↗
[On the diagnostic value of single EEG-recordings in childhood. (On the method of a statistical adaptation of EEG-findings)].
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Child↗
Investigations of the effects of ethanol on warfarin binding to human serum albumin.
Ethanol effects on warfarin binding to human serum albumin (HSA) have been studied by equilibrium dialysis and fluorescence methods at pH 7.4 in phosphate-buffered saline at 37 degrees C. In the presence of various amounts of ethanol fluorescence intensity of bound warfarin decreased significantly but this intensity reduction was not solely from displacement of bound warfarin from HSA. By comparing fluorescence and equilibrium dialysis data we concluded that fluorescence intensity reduction of warfarin was mainly the result of changes in the surrounding environment of the warfarin binding site by ethanol interaction with HSA and that displacement of bound warfarin was not significant compared to the fluorescence intensity changes. The dissociation constant of warfarin binding to HSA decreased with an increasing amount of ethanol. From the changes in fluorescence intensity upon warfarin binding to HSA with the presence of ethanol ranging from 0 to 5.0% the following dissociation constants (Kd) were determined: 0% ethanol 5.39 +/- 0.2 microM, 0.1% ethanol 5.86 +/- 0.1 microM, 0.3% ethanol 5.83 +/- 0.2 microM, 0.5% ethanol 6.76 +/- 0.1 microM, 1% ethanol 7.01 +/- 0.1 microM, 3% ethanol 9.9 +/- 0.7 microM, 5% ethanol 13.01 +/- 0.1 microM. From the equilibrium dialysis with the same ranges of ethanol presence the following Kd values were obtained: 0% ethanol 6. 62 +/- 1.6 microM, 0.1% ethanol 6.81 +/- 1.1 microM, 0.3% ethanol 8. 26 +/- 2.5 microM, 0.5% ethanol 8.86 +/- 1.9 microM, 1% ethanol 11. 01 +/- 4.2 microM, 3% ethanol 20.75 +/- 2.4 microM, 5% ethanol 21.67 +/- 2.2 microM. The results suggest that warfarin bound to HSA was displaced by ethanol. These data indicate that ethanol influence on warfarin binding to HSA may alter the pharmacokinetics of warfarin.
Allosteric Regulation↗
[Hypothyroidism following intermittent administration of potassium iodide].
Iodide-induced hypothyroidism with high TSH and low T4 under long term potassium iodide medication was observed in a toddler suffering from chronic wheezy bronchitis -- in spite of intermittent application. The pathophysiology of iodide-induced hypothyroidism and the apparent immaturity of adaptation to high exogenous iodide in newborn and infants are discussed.
Bronchitis↗