A survey of medical record educational programs: issues and problems.
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Data Collection↗
Biomedical subjects
C E Osborn
Publications and source records attributed to C E Osborn.
Interactions between motor units and Golgi tendon organs in the tibialis posterior muscle of the cat.
The responses of Golgi tendon organs to single motor unit contractions were studied to determine whether receptors located in the same muscle region respond to a common set of motor units. In each of five experiments we isolated a large fraction (25-65%) of the motor units of the cat tibialis posterior muscle and determined to which of the units each of several tendon organs was responsive. Each tendon organ was excited by from two to fifteen of the isolated motor units, including units which produced very small forces. However, there was a much greater probability for large force units to excite a given receptor than for small force units to do so. The number of motor units which produced either an 'unloading' or an 'off response' exceeded, on average, the number of motor units which excited the same tendon organ. The extent to which single motor units excited both of a pair of tendon organs was examined statistically in relation to the mutual proximity of the receptors within the muscle. It was found, on average, that the closer were two receptors, the greater was the number of motor units that excited both of them. These results suggest that despite the extensive territories of individual motor units, the spike trains of tendon organs may still encode information about localized muscle activity.
Action Potentials↗
Records management audit.
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Hospital Departments↗
Cross-correlation analysis of the response of units in the dorsal spinocerebellar tract (DSCT) to muscle stretch and contraction.
Activity of DSCT units was cross-correlated with stimuli evoking gastrocnemius-soleus muscle stretch or contraction in order to investigate the muscle receptor input to DSCT. The most potent stimulus was generally muscle contraction, and the most common response one of inhibition. The similarity in response of many units to stretch, contraction and nerve simulation suggests that Golgi tendon organs are prominent source of input to DSCT, and that much of this input is inhibitory.
Action Potentials↗
The effect of pH on radioimmunoassay of LH and FSH.
Freezing and thawing of human serum produces alkaline changes in the pH. Weak buffers were of insufficient capacity to compensate for these pH changes. Thus the effect of serum pH on modified solid-phase and double-antibody radioimmunoassay (RIA) of LH and FSH was studied. Pooled postmenopausal serum standardized against the Second International Reference Preparation of Human Menopausal Urinary Gonadotropon was used as a laboratory standard. In the solid phase RIA for LH and FSH, slopes with the greatest maximum binding were obtained at pH 6.4, whereas for the double-antibody method best results were obtained at pH 8.0. Since there is individual variation in the pH of various serum samples, different values will be obtained from samples containing the same amount of hormone. It is sum samples be standardized by the use of buffers with the capacity to keep the pH of the serum constant and that serum standards be dialyzed.
Animals↗
DRG analysis reveals potential problems, trends.
Specific DRGs are frequently the targets of review if they are connected to errors. But documentation review alone to identify problems may not be sufficient. The author describes a strategy to review aggregate data for two tricky DRGs.
Aged↗