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Biomedical subjects

C E Newman

Publications and source records attributed to C E Newman.

At least 37 records · Page 2Linked to original sources
PubMed1978

Preparation and characterization of an antiserum to cultured human oat-cell carcinoma cells.

Viable cultured oat-cell carcinoma cells were used to immunize a goat. The resulting antiserum contained high titres of anti-normal activity and antibodies to CEA. It was also shown, by indirect immunofluorescence, using fluorescein-conjugated rabbit anti-goat Ig, to localize at high titres on the surface membranes of human lung cancer cells of 4 different histological types. Booster immunizations produced a maximum secondary response one week after 2 weekly injections. The course of each immunization has been monitored for activity against normal human tissues, and the final sera have been absorbed with human spleen cells to remove anti-normal activity. Cross-reactivity with the lung-cancer-cell panel and antibodies to CEA persisted in high titre after absorption of anti-normal antibodies, and were present in the ammonium-sulphate-precipitated globulin fraction. The cells used for immunization did not produce detectable amounts of CEA in culture, and were not known to contain CEA prior to this experiment. Removal of anti-CEA antibodies by absorption with purified CEA has not reduced the cross-reactivity of the absorbed antiserum with the panel of human lung-cancer cells.

Antibodies, Neoplasm↗
PubMed1977

Antibody-drug synergism: An assessment of specific passive immunotherapy in bronchial carcinoma.

Patients with bronchial carcinoma who had had radical resection of the primary tumour were treated with a combination of drugs and tumour-specific immunoglobulin (antibody-drug synergism, A.D.S.). The antisera were raised in goats by immunisation with tumour cells from patients, and given to those patients after absorption to remove antibody against normal human tissues. 32 patients received A.D.S. treatment and 37 patients received chemotherapy only. Although the differences are not statistically significant there have been 22 recurrences including 15 deaths in the chemotherapy group and 8 recurrences including 6 deaths in the A.D.S group. There was only one clinically significant reaction to heterologous immunoglobulin.

Animals↗
PubMed1977

Roôle of carcinoembryonic antigen in bronchial carcinoma.

It has been reported that lung cancer patients often have raised carcinoembryonic antigen (CEA) levels but the significance of this in diagnosis and follow-up has yet to be established. The results of 256 preoperative investigations in patients with lung cancer are reported. Sequential values after radical surgery and chemotherapy and immunotherapy have been performed in 57 patients during treatment and outpatient follow-up. Ninety-nine per cent of preoperative values were more than 5 ng/ml and 41% greater than 15 ng/ml. Only 6% reached diagnostic levels for malignancy (greater than 52ng/ml) and adenocarcinomas formed 47% (7 out of 15) of these. Sequential estimation in patients during and after treatment showed fluctuations which were related to disease status in 7 (32%) of 22 who have developed secondary disease. In three patients levels of greater than 50 ng/ml preceded clinical evidence of recurrence, and two patients have developed very high levels but have not yet developed other evidence of recurrent disease. It is concluded that raised CEA levels in lung cancer are infrequent, but in those patients who have or develop raised levels sequential investigation may be of value in monitoring response to treatment and clinical coourse.

Adenocarcinoma↗
PubMed1974

Side-to-side antecubital arteriovenous fistulae for haemodialysis.

Initial experience with side-to-side anastomosis of the brachial artery to the median cubital vein is reported in 11 patients in whom it was impossible to use or continue using the more normal sites. Eleven patients have so far been dialysed for a total of 80 fistula months. There was one early failure and no late ones. The appreciable morbidity was considered acceptable in these otherwise difficult patients.

Arteriovenous Shunt, Surgical↗