Biomedical subjects

C E Nelson

Publications and source records attributed to C E Nelson.

58 records · Page 4Linked to original sources

PubMedDate not supplied

Amlodipine overdose.

OBJECTIVE: To report a nonfatal intentional overdose of amlodipine. CASE SUMMARY: A 42-year-old woman with a history of hypertension reported ingesting 50-100 mg amlodipine besylate and at least 40 ounces of beer in a suicide attempt. The patient's symptoms were mild; BP ranged from 79/50 to 113/76 mm Hg and HR from 92 to 129 beats/min (sinus tachycardia). Laboratory studies revealed normoglycemia, mild metabolic acidosis, mild hypocalcemia, blood ethanol concentration of 263 mmol/L, and a serum amlodipine concentration of 88 ng/mL (normal 3-11) 2.5 hours after ingestion. Therapy included activated charcoal, whole bowel irrigation, and intravenous NaCl 0.9%. After receiving 1.5 L of NaCl 0.9%, the patient developed signs of mild pulmonary edema that resolved over several hours without intervention. A serum amlodipine concentration obtained 35 hours later was 79 mg/mL. The patient was discharged on day 2 in good condition. DISCUSSION: In this case, an amlodipine overdose was associated with sustained hypotension and sinus tachycardia, as well as transient pulmonary edema following relatively low-volume fluid replacement. A previously published report described an amlodipine overdose that was fatal due to refractory hypotension and was complicated by concomitant oxazepam overdose. CONCLUSIONS: Amlodipine overdose produces prolonged hemodynamic effects and may lead to pulmonary edema. Due to a long elimination half-life and delayed onset of effects, patients with amlodipine overdose should receive aggressive decontamination therapy and may require extended clinical monitoring and supportive care if they are hemodynamically unstable.

Adult↗

PubMedDate not supplied

Comparison of the test-retest reliability of the Work Box using three administrative methods.

OBJECTIVE: The purpose of this study was to compare the test-retest reliability of three administrative methods of the Work Box: (a) the original instructions, (b) a revised version of the original instructions, and (c) another revised version that was based on suggestions made by authors of the first two versions of the instructions. METHOD: Sixty subjects without disabilities were randomly grouped so that 20 subjects were tested per administrative method. The assessment was administered to each subject on two occasions, with a 7-day to 14-day period between tests. Scores were recorded as time in seconds, and intraclass correlation coefficients (ICCs) were used to calculate the reliability. RESULTS: The ICCs for assembly, disassembly, and total scores were .589, .604, and .654, respectively, for the original instructions; .424, .572, and .545 for the revised instructions; and .781, .579, .717 for the second revised instructions. Reliability was found to be higher for men than for women and for subjects who claimed to have more rather than less experience in similar manual dexterity tasks. CONCLUSIONS: On the basis of the reliability of each administrative method and comments made by subjects about their understanding of the instructions, the second revised version of the instructions is recommended as the standard method. The results also indicate that the assessment is most appropriate for a population of men with manual dexterity experience. With further standardization, the Work Box could be a valuable assessment tool for therapists working in industrial rehabilitation settings.

Adolescent↗

PubMedDate not supplied

The planning process in occupational therapy: perceptions of adult rehabilitation patients.

OBJECTIVES: The purpose of this study was to learn about (a) adult physical rehabilitation patients' perceptions of their involvement in the treatment planning process (goal setting, treatment planning, outcome evaluation), (b) their valuation of occupational therapy, and (c) how they would describe their interpersonal relationships with their occupational therapists. METHOD: Fifteen subjects who had received occupational therapy were interviewed. The transcripts were independently and jointly reviewed by the authors to answer five research questions. RESULTS: Most of the subjects indicated that they had been involved in occupational therapy goal setting; treatment planning; and outcome evaluation, albeit this indication was weak. They also valued the occupational therapy services they received. Eight described positive interpersonal interactions with their therapists, and seven provided no information. CONCLUSION: Patients receiving occupational therapy services are involved in goal setting, treatment planning, and outcome evaluations; however, their involvement varies and can be difficult for them to identify and describe. Because of increasing societal emphasis on patient rights and participation (e.g., consumerism, health professions standards, health care accreditation criteria, health care legislation) and the likelihood that health care funding will be used for services linked to patient goals, occupational therapy practitioners could become more overt and systematic in involving patients in the planning process. Increasing patient involvement in planning may result in more individualized treatment and more effective use of health care dollars.

Adult↗

PubMedDate not supplied

Influence of automatic dishwashings and scrubbings on release of lead from glazed ceramicware.

Use of lead glazes on ceramicware and the release of lead from finished glazes are reviewed. Single units of ceramicware with initial lead leach levels from less than 0.1 to 470 micrograms/mL were subjected to multiple automatic dishwashings with intermediate scrubbing of the ware by plastic fiber pads. Ware was periodically leached with 4% acetic acid solution at room temperature for 24 h, and the solutions were analyzed for lead. Release of lead under these conditions is discussed. Results indicated that neither passive leachings nor multiple dishwashings and scrubbings can predict future lead-release characteristics of glazes and decorations.

Ceramics↗