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Biomedical subjects

C E Mabeck

Publications and source records attributed to C E Mabeck.

At least 55 records · Page 3Linked to original sources

Multipractice studies: significance of the information given to participating doctors.

A total of 1,176 general practitioners were asked to take part in a multipractice study. One group of 568 practitioners was given very detailed information about the study and 19.7 per cent agreed to take part. The remaining 605 practitioners were given only a brief introduction to the study. Of this group 33.4 per cent agreed to take part. Two thirds of the doctors participating in the trial were sent weekly reminders about the study while the remaining third were not. We found that the reminders did not affect the number of patients registered by the practitioners.

Data Collection↗

Multipractice studies: how representative are the participating doctors?

General practitioners participating in a multipractice study were compared with those who refused to participate. We found that younger doctors, doctors in partnerships, and doctors with many patients were represented more among participants. However, no correlation was found between the number of patients examined for urinary tract infection in connection with the study.

Data Collection↗

Treatment of urinary tract infections with sulphonamide and/or trimethoprim. A preliminary report from a multipractice study.

In a double-blind study 1194 patients with bacteriologically diagnosed urinary tract infection were randomly selected for treatment with either 1 g sulphamethizole twice daily, 200 mg trimethoprim twice daily, or 410 mg sulphadiazine plus 90 mg trimethoprim twice daily. All drugs were administered perorally for seven days. Two weeks after commencement of therapy 70% of the patients treated with sulphamethizole, 80% of those treated with trimethoprim and 85% of those treated with sulphadiazine/trimethoprim had sterile urine. After ten weeks 25% of the patients had bacteriuria irrespective of the form of treatment. Side-effects such as skin reactions occurred in 4.1% of the patients treated with trimethoprim alone, in 1.4% of those treated with sulphamethizole and in 3.2% of those treated with trimethoprim/sulphadiazine.

Adolescent↗

Mortality from chronic interstitial nephritis and phenacetin consumption in Denmark.

After 1950, a pronounced increase in the mortality from chronic interstitial nephritis among women was registered in Denmark. This was suspected to be caused by a contemporary increase in the consumption of drugs containing phenacetin. Restrictions were therefore imposed on the sale of such drugs in 1961 and consumption decreased sharply. This report, based upon death certificates from 1941--76, shows that the mortality rate from chronic interstitial nephritis has decreased gradually among women in Denmark since 1960, and has now reached the same level in younger women as in the 1940's.

Chronic Disease↗