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Biomedical subjects

C E Leifer

Publications and source records attributed to C E Leifer.

23 records · Page 2Linked to original sources
PubMed1982

Salmonellosis in dogs with lymphosarcoma.

In 6 dogs with multicentric lymphosarcoma, salmonellosis developed shortly after the start of anticancer chemotherapy. Three of the dogs died. Signs of illness in those that died were vomiting, diarrhea, neutropenia, anorexia, and fever, usually within 3 days of the start of chemotherapy.

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PubMed1982

Lymphocyte blastogenesis in dogs with lymphosarcoma.

Mitogen-stimulated lymphocyte blastogenesis was evaluated, using lymphocytes from 37 dogs with multicentric lymphosarcoma. The majority of the test results was within a normal range, even for those dogs with more advanced disease. However, depressed lymphocyte blastogenesis, when present, almost always occurred in lymphocytes from dogs with clinical stage IV-B and V-B disease. Dogs weighing greater than 25 kg had a significantly (P = 0.04) higher occurrence of clinical stage IV or V disease as compared with dogs weighing less than 15 kg. Dogs with diffuse lymphocytic well-differentiated lymphoma were statistically more likely to be designated clinical stage III at the time of diagnosis, as compared with dogs with diffuse lymphocytic poorly differentiated lymphoma.

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PubMedDate not supplied

Chemotherapy versus chemotherapy plus radiotherapy in the treatment of tonsillar squamous cell carcinoma in the dog.

The effect of adjuvant chemotherapy and combined chemotherapy and radiotherapy in 22 dogs with advanced canine tonsillar carcinoma (World Health Organization [WHO], T2-3 primary tumor with infiltration into surrounding tissues) was evaluated. There were four treatment groups of at least five dogs each. Combinations of chemotherapeutic drugs reported to have activity against squamous cell carcinoma in humans and dogs (doxorubicin, cisplatin, vinblastine, and cyclophosphamide) were administered after tonsillectomy. Radiation therapy (orthovoltage type, external beam) was combined with chemotherapy in one treatment group. The dogs that had combination radiation therapy and chemotherapy had higher response rates and significantly longer survival times. However, most dogs died of progression of disease.

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