Biomedical subjects
Publications and source records attributed to C E Harvey.
This article describes the technique of taking intraoral radiographs and developing film. Interpretation of oral radiographs is described. Radiation safety is reviewed. A troubleshooting section is included.
There are several factors in the etiopathology of feline resorptive lesions. They may be considered as local immune-response mediating cell and humoral factors; release of biochemical components in dental and paradental tissues to attract odontoclasts; mechanical stress, including occlusal mechanism; and local and systemic calcium regulation, including remodeling of mineralized tissue and dietary intake of calcium.
Surveys were carried out in cats presented for dental examination in the Netherlands (432 cats) and in the United States (78 cats). In 62% of the Dutch cats and 67% of the US cats, resorptive lesions were present. In the Dutch study, Asian Short-hair (principally Siamese) cats were most commonly involved, and male cats were more commonly affected than females. The most commonly affected teeth were the fourth maxillary premolar and the mandibular premolar and molar teeth.
Numerous types of veterinary orthodontic treatments are reported in papers and during meetings, however little is generally known concerning craniofacial growth in dogs. Most statements in veterinary dental publications are drawn from human-oriented studies. This makes decision making in veterinary orthodontics difficult. The purpose of this paper is to review studies of craniofacial growth performed in dogs.
Malocclusions may be associated with any of the cranial shapes recognized in dogs. Orthodontic treatments for malocclusions are frequently reported. However, these reports often lack a diagnostic plan and use confusing terminologies. The purpose of this paper is to describe, using standardized terms, a diagnostic approach to the most common malocclusions found in dogs.
Classifications of malocclusions in dogs have superficially followed the Angle's system. Since teeth anatomy and occlusal relationships are not the same for dogs as for humans, the use of the Angle's system can be misinterpreted. The proposal for a system for classification of malocclusions specific to the dog is presented with a discussion of the Angle's classification of malocclusions.
Periodontal disease occurs naturally in a wide range of species from rodents to humans. Clinical studies document the development of periodontal disease. Histopathology reveals the inflammatory response to plaque accumulation. This article presents a review of the clinical and histopathological features of periodontal disease in the dog.
Periodontal disease in the domestic cat may assume debilitating and serious consequences; however, little is known of the biochemical composition or metabolism of feline gingiva in health or disease. In this report the chemical composition and metabolism of gingival lipids from inflamed an non-inflamed sites is presented and compared to other species with naturally occurring periodontitis. The neutral and phospholipid composition of feline gingiva was found to be distinct from that of porcine and human. As a measure of de novo lipid synthesis, the total incorporation of 14C-acetate into fractionated lipid components was determined and revealed an approximate 2 to 3 fold decrease in inflamed versus non-inflamed gingiva. The decrease in 14C-acetate incorporation appeared to result from a 2-fold increase in free acetate pools in inflamed compared to non-inflamed gingival samples, since total lipase and phospholipase activity were comparable in inflamed and non-inflamed gingiva and total lipid composition was not changed between inflamed and non-inflamed sites. These data are similar to those reported for periodontally involved human gingival tissue and suggest a common effect of periodontal inflammation on lipid metabolism in both species.
The importance and the role of spirochetes in periodontal disease is controversial since the means to study these particular bacteria are limited. Because of specific requirements for growth, spirochetes are difficult to culture. Spirochetes could have profound effects on the perpetuation of periodontal disease. A review of the literature related to spirochetes is described.
As anaerobic sampling and culture techniques improved, the documented prevalence of anaerobic bacteria in periodontal disease has increased. The anaerobic bacteria have become more well-known in humans and consequently in dogs, since this species is a major model in periodontal studies. A review of the literature related to anaerobic flora is described.
Periodontal disease has been shown to be caused by bacteria. Periodontal inflammation results as the plaque bacteria change from a predominantly non-motile, Gram-positive, aerobic coccoid microbiotal flora to a more motile, Gram-negative, anaerobic, rod-shaped flora. A review of the literature related to aerobic flora is included. The important effects of aerobic flora as well as their importance in contributing to periodontal disease development is reported.
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The neutralisation patterns of 103 recent isolates of feline calicivirus from cats with chronic stomatitis or acute feline calicivirus disease, and from cats with neither oral nor respiratory disease were compared. There were no statistically significant differences between the proportions of isolates from each clinical source neutralised by individual feline calicivirus cat antisera. Different antisera showed widely differing degrees of cross reactivity; antisera to the most widely used vaccine strain F9 being the most cross reactive, neutralising 54 per cent of all the field isolates, and antisera to a field isolate LS015 the next most cross reactive, neutralising 29 per cent of the field isolates. However, the cross reactivity of antisera to early British isolates (A4, 68/40 and 69/1112) was much reduced (overall less than 10 per cent) whereas in the early 1970s 65 per cent of 117 field isolates from clinically normal cats were neutralised by A4 antiserum, and 40 per cent by each of 68/40 and 69/1112 antisera. This suggests a change in the spectrum of antigenicity among feline calicivirus isolates over the past 15 years. However, the cross reactivity of F9 antisera appeared to be similar to that in earlier studies. The relevance of these findings to vaccination is discussed.
Survival time and 31 prognostic factors were analyzed for 70 dogs undergoing radiotherapy for intranasal tumors at the Veterinary Hospital of the University of Pennsylvania between 1974 and 1985. At the time of analysis (January 1987), 14.3% (10 of 70) of the dogs were alive. Of the remaining dogs, 34 died because of tumor recurrence, 14 died because of intercurrent disease, and 12 were lost to follow-up evaluation. Pretreatment prognostic factors that were significantly correlated with disease-free interval or long-term survival could not be identified. Notably, presence of a facial mass was not prognostically significant, suggesting that extensive disease should not preclude treatment. Median survival time of dogs with all tumor types was 16.5 months, with a 1-, 2-, and 3-year survival of 54%, 43%, and 35%, respectively. Median survival time of dogs with carcinoma was 13.5 months, with 1-year survival of 51%, 2-year survival of 37%, and 3-year survival of 31%. Orthovoltage radiation was efficacious in the treatment of canine intranasal tumors.
Severe pectus excavatum sternal deformity in a 3-month-old kitten was repaired by use of percutaneous circumcostal and circumsternal sutures to coapt the sternal deformity to an external splint made from thermoplastic material. One year after treatment, the kitten remained free of clinical signs of the disease or complications from the repair. The technique represents a conservative method of repair of pectus excavatum deformities in immature animals.
The prevalence of feline calicivirus (FCV), feline leukaemia virus (FeLV) and feline immunodeficiency virus (FIV) antibodies were assessed in 78 British and 18 North American household cats with chronic stomatitis and in appropriate controls. In British cats, FCV was significantly (P less than 0.005) more prevalent in both hospital (92 per cent) and general practice (79 per cent) cases compared to their controls (19 per cent in both cases). A similar difference in prevalence of FCV was noted in North American cats where 50 per cent of cases were positive compared to 0 per cent of controls (P less than 0.01). FeLV prevalence was low in all chronic stomatitis populations. A significantly higher prevalence of antibody to FIV was found in British hospital cases (81 per cent) compared with time-matched controls (16 per cent) (P less than 0.001): a similar rate was found in the general practice cases (75 per cent) for which no controls were available. In the North American sample, FIV antibody status was similar in cases (54 per cent positive) and their age, sex and breed matched controls (50 per cent). The possible role of FCV and FIV in the pathogenesis of feline chronic stomatitis is discussed.
Subgingival plaque samples were obtained from 32 cats showing different stages of periodontal disease. Correlations were sought between gingival index scores and the prevalence of various microbial groups, and between microbial populations found in sites designated as most-affected and least-affected within individual cats. The tendency with higher gingival index scores, and with the most-affected sites, was toward a microbial population composed to a greater extent of anaerobic Gram-negative rods. The most common organism was an anaerobic Gram-negative rod in the black-pigmented Bacteroides group that was biochemically similar to B. gingivalis but had catalase activity. The black-pigmented Bacteroides group and Peptostreptococcus anaerobius were found in increasing numbers with increasingly severe periodontal disease. Pasteurella multocida was isolated from most samples and appeared to decrease in numbers with increasing periodontal disease.
Oropharyngeal disease is common in dogs and cats. Signs are seldom apparent to the owner until the disease is well advanced, and often are not specific for a particular disease. Signs include inappetence, pawing at the mouth, drooling of saliva, dysphagia, and halitosis. These signs can result from primary oral disease, or from effects of systemic or skin disease. Oral examination requires a cooperative patient; sedation may be necessary so that the entire oral cavity can be examined without causing the animal pain or risking injury to the examiner.