Biomedical subjects
Publications and source records attributed to C E Fox.
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The Public Health Foundation (PHF), under contract to the U.S. Department of Health and Human Services, Public Health Service (PHS), worked with federal, state, and local public health, mental health, substance abuse, and environmental agencies in nine states to develop and successfully test a methodology for estimating investments in essential public health services. Estimates from the nine-state sample revealed the predominance of personal health expenditures in the public health system. Of total state health care dollars, only 1 percent was spent on population-based health services by participating agencies. This pilot provides a rational starting point toward a uniform methodology for highlighting public health expenditures that may be critical in revealing the effects of a changing health care environment on the nation's health. In combination with other data, results are expected to lead to a more informed policy-making process.
The value of laser Doppler flowmetry in measuring blood flow through the lung was assessed comparing it with flow measured by electromagnetic flowmetry. This was an experimental laboratory-based prospective study performed in an approved University animal research facility. Ten beagle dogs were used. Simultaneous measurement of pulmonary blood flow by laser Doppler flowmetry and electromagnetic flowmetry was carried out at varying degrees of pulmonary artery constriction. There was a linear relationship between the two methods of assessing blood flow (regression equation: y = 0.9x + 5.5; p = .00001) using a least-squares, best fit, straight line analysis (160 data points). The results of this study demonstrate that laser Doppler flowmetry provides an accurate indicator of pulmonary blood flow, which in practice is both simple and reproducible.
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A number of patients with ACTH unresponsiveness resulting in glucocorticoid deficiency with normal mineralocorticoid activity have been described. This could be due to an inherited defect within the adrenal gland causing primary unresponsiveness to ACTH or to an inherited progressive degenerative process. The association of achalasia, lack of lacrimation, and glucocorticoid deficiency in two pairs of siblings with normal mineralocorticoid activity has been recently reported. Our case describes an 8.8-yr-old female with glucocorticoid insufficiency, partial mineralocorticoid deficiency, achalasia, and evidence of decreased lacrimation. Sodium depletion produced hyponatremia, and she was unable to increase her plasma aldosterone levels sufficiently, although PRA was markedly elevated. Our case may be part of a progressive degenerative process, possibly affecting both the autonomic nerve structures and the adrenal gland, leading not only to glucocorticoid deficiency but also to abnormal mineralocorticoid secretion.
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