Phencyclidine (Sernylan) poisoning.
Explore the source record for details and available documents.
Adolescent↗
Biomedical subjects
C E Costello
Publications and source records attributed to C E Costello.
Fundamentals of present-day mass spectrometry.
Mass spectral analysis offers much to the field of clinical pharmacology: specificity, sensitivity, reliability, and potential for the structural determination of unknown compounds, even when they are present at very low concentrations as part of complex mixtures. In order to employ mass spectrometry effectively, the researcher or analyst must acquire an understanding of the fundamental processes involved in the technique and some overview of the strengths and limitations of the different options now available. This brief summary is presented as an introduction to the field and should provide the impetus for further reading by the interested investigator.
Chemical Phenomena↗
Synthesis, mass spectral characterization and immunoadjuvant activity of some novel lipophilic derivatives of muramyl dipeptides.
Some novel lipophilic derivatives of N-acetylmuramyl-L-alanyl-D-isoglutamine (MDP) have been prepared and rigorously evaluated by spectroscopic means. Fast atom bombardment and field desorption mass spectrometry provided information about both molecular weight and structural detail. The new MDP derivatives have been tested in guinea pigs for immunoadjuvant activity using egg albumin as the model antigen. Amongst these derivatives, 6-O-[3-(5-cholesten-3 beta-yloxycarbonyl) propionyl]-N-acetylmuramyl-L-alanyl-D-isoglutamine (CSMDP), 6-O-[3-1,2-dipalmitoyl-sn-glycero-3-carbonyl) propionyl]-N-acetylmuramyl-L-alanyl-D-isoglutamine (GSMDP) and N-palmitoyl muramyl-L-alanyl-D-isoglutamine (PMDP) possessed significantly better activity than MDP, as judged by the antigen-specific antibody and delayed hypersensitivity responses in the immunized animals. In addition, CSMDP was found to induce strong delayed hypersensitivity response even in saline. These three active compounds were also tested for their pyrogenic response in rabbits, and were found to be lesser pyrogenic than MDP. Some of these MDP derivatives hold promise as adjuvants in immunization.
Acetylmuramyl-Alanyl-Isoglutamine↗