Biomedical subjects
C E Connolly
Publications and source records attributed to C E Connolly.
Brief report: primary choriocarcinoma of the mediastinum.
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Primary sarcoma of the heart: a light and electron microscopic study of two cases.
Two cases of primary malignant cardiac neoplasms are presented. The first, an angiosarcoma of the right atrium, developed in a 44-year-old housewife, who survived 23 days from the time of presentation; diagnosis was made at necropsy. The second, an embryonal rhabdomyosarcoma of the right ventricle, developed in a 17-year-old student; diagnosis was made by angiocardiography. He underwent surgery and cytotoxic and irradiation therapy and died 14 months later.
Receptors for Fc and complement in human breast carcinoma.
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Nodular transformation of the liver: report of a case.
Cases of portal hypertension, other than those caused by cirrhosis, are uncommon. We report a rare disorder of the liver parenchyma causing portal hypertension, which can be difficult to diagnosis ante mortem, even with a full liver work-up including biopsy.
Tumour-directed leucocyte migration inhibition in operable breast cancer: additional clinical correlations.
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Letter: Prognostic indications in cancer.
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Acute leukemia in Hodgkin's disease.
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Triploidy (69,XXY) in a liveborn infant.
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Prognostic implications of p53 and bcl-2 expression in 108 women with stage two breast cancer.
BACKGROUND: The mortality and morbidity of patients with breast cancer can vary even between individuals with similar histological stage at diagnosis. Identification of those individuals with prognostically poorer tumours is an essential prerequisite in planning adjuvant therapies. Some prognostic indices of tumour size, grade, oestrogen receptor status and nodal status are well established. AIM: The aim of this study was to examine the prognostic role of information relating to proto-oncogene and tumour suppressor gene expression. METHODS: 108 women with stage II breast cancer were studied. Tumour expression of p53 and bcl-2 were scored and then correlated with recurrence and mortality. RESULTS: We have shown that individuals poorly expressing bcl-2 in their tumours have a poorer disease-free and overall survival than those who express bcl-2. When p53 was strongly expressed, it was associated with poorer disease-free and overall survival. CONCLUSION: The profiling of individual tumour genetic expression of proto-oncogenes may allow for more specific identification of patients at higher risk of recurrence in breast cancer.
Mortality in epilepsy in the west of Ireland: a 10-year review.
BACKGROUND: Sudden and unexpected death is not an uncommon event in otherwise healthy epileptics. AIMS: To study the autopsied cases of sudden death in known epileptic patients in the West of Ireland. METHODS: A retrospective study was carried out which involved the review of 3,103 autopsy reports over a 10-year period in Galway University Hospital. RESULTS: Twenty-two cases were classified as sudden, unexpected death in epilepsy (SUDEP). Forty-five per cent had been found dead in bed. The mean age was 38 years and 68% were males. Of 16 cases with data about antiepileptic drug (AED) levels, 68% had absent or low levels at postmortem. Eighty-eight per cent of the cases had a past history of a generalised seizure. Pulmonary oedema was present in 86% of cases at postmortem. CONCLUSIONS: Compliance with treatment and frequent nightly observations to those at high risk of sudden death may help to minimise its incidence. The patients and their families should be aware of this potential outcome.