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Biomedical subjects

C E Alpers

Publications and source records attributed to C E Alpers.

167 records · Page 10Linked to original sources
PubMed1983

Experimental study of the sonographic diagnosis of testicular torsion.

The sonographic and Doppler features of acute spermatic cord torsion were investigated in eight dogs. Serial sonography following torsion demonstrated unambiguous abnormalities in all experimental subjects within one hour. The observed abnormalities included increase in size of the spermatic cord, testis, and epididymis, decrease in echogenicity of the testis and epididymis, and loss of Doppler signal from the cord. Sonographic abnormalities were clearly visible before any histologic change was detected and well in advance of the onset of cellular necrosis. Since every experimental subject had an abnormal testicle, the identification of a normal testicle in a clinical setting is felt to exclude torsion. Combined gray-scale sonographic and Doppler features appear promising in the diagnosis of acute spermatic cord torsion and its distinction from acute epididymo-orchitis.

Animals↗
PubMed1982

Persistence and late malignant transformation of childhood cerebellar astrocytoma. Case report.

A 5-year-old girl with juvenile pilocytic astrocytoma subsequently had multiple episodes of symptomatic recurrence over the course of 21 years of follow-up review. This lesion underwent histological transformation to an anaplastic small-cell neoplasm 21 years after the initial resection and diagnosis. Late transformation of benign childhood cerebellar astrocytomas to malignant astrocytic tumors is very rare; transformation to an anaplastic small-cell neoplasm has not been reported previously. This case and other reported cases in which juvenile pilocytic astrocytoma recurred after a long interval indicate the requirement of long-term follow-up review of these patients before assuming either a cure or arrest of the tumor's growth.

Astrocytoma↗
PubMedDate not supplied

Techniques for high-resolution MR imaging of atherosclerotic plaque.

Atherosclerotic cardiovascular disease is the most common cause of death in the United States. Investigation of atherosclerotic plaque morphology and composition is important because the findings may be useful in predicting prognosis or response to therapy. This study presents high-resolution magnetic resonance (MR) imaging techniques developed on a 1.5-T whole-body imager with a custom-built surface coil, for characterizing the composition and morphology of plaque removed at carotid endarterectomy. The initial comparison of MR imaging and histologic results showed good correlation. In conjunction with MR angiography, these techniques could be used in in vivo imaging to define the size, location, and contents of atherosclerotic plaque at the carotid bifurcation.

Artifacts↗