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Biomedical subjects

C Duval

Publications and source records attributed to C Duval.

At least 73 records · Page 4Linked to original sources

[Epidemiologic study of extra-uterine pregnancy. Apropos of 375 cases].

From a retrospective study over 11 years of 375 ectopic pregnancies, the authors have analyzed the epidemiological factors that could account for a very sensible and regular increase of the frequency of this gravidic accident. If a past history of tubal infection is usually considered as a major cause, in this series, we must mainly consider the abnormal frequency of the use of a modern contraceptive method at the time of the ectopic pregnancy, found in 32% of the cases. The place and the role of intra-uterine devices are discussed since a coil was associated with an ectopic pregnancy in 22.5% of the patients while the notion of a previous usage does not seem to be a predisposing factor: approximately only 2% of these patients had resorted to it. A hormonal contraception in progress may also lead to a late diagnosis, especially in patients using mini and micro-pills (8% of ectopic pregnancies). Finally, the advantages of conservative tubal surgery contingent on an earlier diagnosis are kept in mind by the authors because of the persistence of a high recurrence rate on the contralateral side, even after salpingectomy.

Adolescent↗

Effects of rat ovariectomy on CSF monoamine metabolite levels and elimination.

Cerebrospinal fluid (CSF) was removed from the third ventricle of anesthetized male, female, and ovariectomized rats. CSF 3,4-dihydroxyphenylethylamine and serotonin metabolite levels [dihydroxyphenylacetic acid, homovanillic acid (HVA), and 5-hydroxyindoleacetic acid (5-HIAA)] were determined on 15-min samples by liquid chromatography coupled with electrochemical detection. Monoamine oxidase inhibition was used for studying metabolite turnover in the CSF. No difference was observed between male, ovariectomized, and sham-operated female rats. However, ventricular CSF HVA and 5-HIAA levels were significantly higher in the ovariectomized than in the sham-operated rats. These differences do not reflect effects of ovariectomy on brain metabolite production but indicate slower metabolite elimination from the CSF.

3,4-Dihydroxyphenylacetic Acid↗

[Elevation of intraplatelet free Ca2+ in primary hypertension in man and the rat].

Cytosolic free Ca2+ concentrations were measured in platelets from hypertensive and normotensive humans and rats with the use of the fluorescent indicator Quin-2/AM. Without external Ca2+ added, no difference was observed between platelets of hypertensive patients and those normotensive subjects or between platelets of spontaneously hypertensive rats and those of the normotensive Wistar Kyoto and regular Wistar rats. In the presence of 0.5-1 mM external Ca2+, the cytosolic free Ca2+ concentrations were higher both in patients with essential hypertension and rats with genetic hypertension than in their respective normotensive controls. These results suggest that primary hypertension is accompanied by a disequilibrium between cellular Ca2+ influx, storage and extrusion. Such a characteristic if present in other excitable cells and in particular in vascular smooth muscle cells may play a major role in the rise of peripheral resistances.

Adult↗

The maximum exercise stress test: is it a behavior-modification tool?

The controlled study presented demonstrates the results obtained when using the maximum exercise stress test (MEST) as a behavior-modification tool for coronary artery disease risk factors. Changes in attitudes, behaviors, and objective measurements of health were assessed in a low-risk population. Only exercise level was significantly altered (P less than .03). Changes in the other measured parameters were insignificant. The MEST test is also expensive, and no benefit has been demonstrated in terms of its ability to decrease the morbidity and mortality seen in coronary artery disease.

Adult↗

[Development and comparison of lecithin/sphingomyelin and palmitic acid/stearic acid ratios in amniotic fluid].

Fetal lung maturity has been studied both by silica gel chromatography of phospholipids and gas liquid chromatography of fatty acids. Lecithin/sphingomyelin (L/S) ratios and palmitic/stearic (P/S) ratios were compared. A good correlation was obtained. However, when the L/S ratio has an intermediate value (1.5 less than or equal to L/S less than 2) making it difficult to judge the fetal lung maturity, the P/S ratio expresses the lung maturity more accurately.

Amniotic Fluid↗

P50 values of non smoker and smoker pregnant women.

The influence of tobacco smoke during pregnancy on haemoglobin concentration and oxygen affinity of smoker women has been studied. Fifty-nine non smoker (NSW) and forty-five smoker women (SW) were investigated during pregnancy and early puerperium. Results have shown: 1) a slight non significant increase in oxygen affinity of SW; 2) a significant decrease in oxygen affinity in SW at term and early puerperium, the same as in NSW; 3) a significant increase in haemoglobin concentration of SW at term as compared to NSW. The small modifications of oxygen affinity of SW and the increase in haemoglobin concentration at term suggest that the oxygen delivery from the maternal to the fetal blood are probably unaffected by these factors.

Female↗