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Biomedical subjects

C Dupont

Publications and source records attributed to C Dupont.

349 records · Page 20Linked to original sources
PubMedDate not supplied

[Effects of tabernanthine on various cardiovascular parameters in the rat and dog (author's transl)].

1. Tabernanthine produced, in anaesthetized Rat and Dog, bradycardia and hypotension which remained after atropine or vagotomy. Bradycardia was significant from 0,5-0,8 mg . kg-1. The degree of hypotension depended upon the anaesthetic. 2. Effects of tabernanthine on cardiovascular parameters in anaesthetized Dog (blood pressure, heart rate, cardiac output, left ventricular pressure, dp/dt, cardiac potency, cardiac work and ventricular ejection volume) are described. There were no changes of noradrenaline, acetylcholine, tyramine or 5-hydroxytryptamine-induced cardiovascular effects by tabernanthine. 3. Bradycardia occurred also after per os tabernanthine administration in unanaesthetized Dog. 4. Tabernanthine reduced Rat isolated and perfused heart frequency. 5. It is suggested that tabernanthine has a direct action on myocardial muscle, probably by modification of calcium exchanges.

Alkaloids↗
PubMedDate not supplied

[Measurement of cutaneous blood flow by laser Doppler velocimetry. Importance of probe effect and solvent effect after topical application].

A comparative methodological study of the probe and/or vehicle effects was performed in Human volunteers with two laser Doppler velocimeters (L.D.V.): Laserflo BPM 403, T.S.I., U.S.A. and Periflux PF2B, Perimed, Sweden. Individual variations of skin blood flow are great (up to 1,400%); this could be related to spontaneous variations and/or to the occlusive effect of the probe. Skin blood flow was significantly increased in 35% of the subjects after the application of the probe alone, and in 70 to 90% of the cases after topical application of water or ethanol (20 to 50 microliters). Lag times before vasodilatation measured only when the probe was applied on the skin were between 7.4 and 27 minutes, they were reduced between 5.2 and 8.3 minutes when the vehicles were applied. These data suggest that in any protocol for L.D.V. determination an absolute control and a vehicle control should be included to evaluate objectively topical vasoactive drugs.

Administration, Topical↗
PubMedDate not supplied

Atopic eczema.

Explore the source record for details and available documents.

Allergens↗
PubMedDate not supplied

[Vasoactive intestinal polypeptide (VIP) tissue distribution in the rat as measured by radioimmunoassay and by radioreceptorassay (author's transl)].

A new radioimmunoassay which allows the measurement of the rat vasoactive intestinal polypeptide, was performed. VIP is present in the whole digestive tract of rat, mainly between the duodenum and the colon. 1.5% of the total VIP is present in brain. The VIP-like immunoreactivity appears to correspond to biologically active molecule since a radioreceptorassay using liver plasma membranes as the target tissue, gives the same results as the radioimmunoassay.

Animals↗