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C Dumitrescu

Publications and source records attributed to C Dumitrescu.

At least 73 records · Page 4Linked to original sources
PubMedDate not supplied

[Gastric stromal tumors--Clinical and histopathological analysis of four cases].

BACKGROUND: The aim of this study is to present our experience concerning a rare form of gastric tumor--gastrointestinal stromal tumor (GIST). METHODOLOGY: We reviewed data of four patients with gastric stromal tumors, which have been admitted in our department from 1998-2002. RESULTS: There were two females and two males with age of 75, 70, 65 and 63 years old. The average duration of symptoms until hospital admission was 7 days. During surgery we discovered proximal gastric tumors with 4, 5, 10 and 20 cm in largest diameter. We performed excision of the whole tumor with a security limit of 2 cm or gastric resection (one case), without limphadenectomy. One patient developed an anastomotic fistula with a good evolution under conservative treatment. All patients left the hospital in a good condition. Histopathological and immunohistochemical study diagnosed gastric stromal tumors by identifying the CD 117 maker. Postoperatively neither one of our patients received chemotherapy or radiotherapy. One female and one male patient died of peritoneal metastasis at nine months and respectively two years after operation. The other two patients are in a good condition up to date, without metastasis, one and respectively three years after surgical treatment. CONCLUSIOUS: Correct diagnosis, complete tumor resection and surveillance are essential steps in management of gastric stromal tumors.

Aged↗
PubMedDate not supplied

[Hereditary pancreatitis].

We present the cases of three brothers (a woman and two men) with recurrent attacks of necrotic acute pancreatitis that were treated in our clinic. Two of them have diabetes mellitus controlled through insulin treatment. All patients have presented the first episode of acute pancreatitis around age of 35. We have observed a high level of serum triglyceride at admission, without evidence of lipid disorder. In addition we couldn't identify other causes of these episodes of acute pancreatitis (biliary stones, alcohol, trauma, drugs, lipid disorders). During the last year two members of this family presented recurrent attacks of abdominal pain without any biochemical or imaging signs of acute pancreatitis.

Adult↗
PubMedDate not supplied

Association of hyperthyroidism and ulcerative colitis. Report of two cases.

The association of hyperthyroidism and ulcerative colitis (UC) is presented in two cases: a 61-year-old man and a 54-year-old woman. In the first case the onset of hyperthyroidism was detected at the age of 25, and the onset of ulcerative colitis at the age of 36. The second case presented severe hyperthyroidism started at the age of 51. In the latter case ulcerative colitis had been detected ten year earlier. To our knowledge this report seems to be the first one considering this association from the endocrinological standpoint. The association of these two diseases might suggest that the disturbance of even one organ specific immune lesion implies a wider disorder. Thus one might assume that the association of multiple organ-specific immune diseases represents an unsuccessful attempt to equilibrate the repertoire of idiotypes and anti-idiotypes belonging to the immune network.

Autoimmune Diseases↗
PubMedDate not supplied

A study on the types of diabetes mellitus in first degree relatives of diabetic patients.

The genetic characteristics of the diabetic types have been assessed by following up their frequency in first degree relatives of some non-selected diabetic patients, registered at eight different centers of the country. Out of 1,003 non-diabetic controls only 46 (4.6%) had 52 diabetic relatives, 65.4% of type 2 (non-insulin-dependent). Comparatively, out of the 704 patients, 172 (24.4%) had 229 diabetic first degree relatives, 72.5 of type 2. Out of 231 type 1 (insulin-dependent) diabetic patients, 29 (12.6%) had 34 diabetic relatives, 55.9% of type 1. Out of 300 type 2 patients, 99 (33.0%) had 121 diabetic relatives, 84.0% of type 2. The other 173 diabetic patients presented an "intermediary" type of the disease (needing insulin many years after onset). Forty-four (25.4%) of them had 64 diabetic relatives, 67.2% of type 2, 20.3% of type 1 and 12.5% with "intermediary" diabetes. The five times higher frequency of diabetes in patients' relatives versus controls is pointed out. Type 2 diabetic relatives predominated. The proportion of probands with diabetic relatives increased from 4.6% in non-diabetics to 12.6% in type 1, to 25.4% in "intermediary" diabetes and to 33.0% in type 2. The heredity of type 1 prevailed in type 1 and that of type 2 in type 2 and in "intermediary" diabetes. The fact that "intermediary" diabetes tends towards type 1 (insulin-dependent) as therapy and towards type 2 (non-insulin-dependent) as heredity might be an argument supporting the controversy on the diabetic syndrome classification.

Adult↗
PubMedDate not supplied

Decrease of serum immunoglobulin M levels in some diabetic patients.

Contradictory results have been published on serum immunoglobulin levels in diabetes. Our study population consisted of 26 "juvenile" IDDM patients (males/females 14/12, mean age 15.8 +/- 2.4 yrs), 42 "adult-onset" IDDM patients (25/17, 45.1 +/- 15.2 yrs), 62 NIDDM patients (27/35, 59.8 +/- 7.7 yrs), 128 controls. IgM has been measured by a highly standardized endpoint radial immunodiffusion. Since age and sex significantly influence serum IgM levels, we calculated Z values using the formula: log (Xobs:Xexp): SDexp, where Xobs is the measured IgM in any individual and Xexp and SDexp are the expected (geometric) mean and standard deviation of the log IgM values for each year of age in both sexes, as previously calculated by orthogonal polynomials from a large population of "laboratory controls" (n = 755; 10-70 yrs). These Z values (+/- SD) in juvenile IDDM (-0.442 +/- 0.988) and NIDDM (-0.559 +/- 1.215) were significantly lower (P = 0.035 and P less than 10(-3)) than in "laboratory controls" (0 +/- 1). Values in adult IDDM (-0.0225 +/- 1.213; P = 0.24) and in controls (-0.018 +/- 1.04) did not differ significantly from the "laboratory controls". The prevalence of diabetes within the four quartiles of the IgM distribution differed significantly from the one expected according to the null hypothesis (chi-square = 42.2; 3df; P less than 10(-4]. This is also applied to juvenile IDDM (P less than 0.05) and NIDDM (P less than 10(-4], but not to adult-onset IDDM. These results suggest that the low IgM levels may partly contribute to the poorly explained increase in susceptibility to infections in some diabetics.

Adolescent↗
PubMedDate not supplied

Is microalbuminuria a different problem for type I and type II diabetes mellitus?

As in previous studies an improved single radial immunodiffusion technique was used for albumin, calculating the albumin/creatinine ratio in spot urine (mg/g/1.73 m2). This ratio was 4.7 +/- 0.0174 (geometric mean +/- SEM as logarithm) in 130 healthy controls, the highest value being 10.8. The 182 non-selected ambulatory diabetic patients presented three subgroups, each showing a non-gaussian frequency distribution: 47% with normal values (5.0 +/- 0.0224); 42% with ratio values from 11.0 to 88.8 (22.7 +/- 0.0269, significantly differing from the controls); 11% with clinical proteinuria (subsequently excluded from the study). Type I (9.6 +/- 0.0452; n = 76) and type II diabetic patients (10.7 +/- 0.0430; n = 86) significantly differed (p less than 0.001) from the controls but not from one another. Irrespective of the diabetes type, ratio values were significantly correlated with the duration of diabetes, age of patients, age of diagnosis (for instance 16.2 +/- 0.0974 in 15 patients aged greater than 65 years versus 9.1 +/- 0.0792 in 23 patients aged less than 20 years), glycemia level and chronic complications (especially retinopathy). Therefore, more than half the diabetic patients, non-selected, presented an increased albumin excretion as compared to the controls. On the other hand, microalbuminuria appears to be linked to age, duration of the disease and quality of the metabolic control rather than to the diabetes type.

Adolescent↗
PubMedDate not supplied

Therapy with irritren in rheumatic degenerative diseases.

The antirheumatic effect of a new nonsteroidal antiinflammatory drug, irritren, a derivative of arylacetic acid namely ionazolac calcium was studied. The favourable effect of irritren treatment in reactivated arthrosis was compared to that of indomethacin. To this end 40 patients were divided into two groups of 20 patients each who were treated for 14 days with: irritren in daily doses of 3 X 200 mg-Group I, and with indomethacin in daily doses of 3 X 25 mg-group II. The results obtained at the end of the experiment showed a marked decrease of joint pain and of inflammation in 85% of the patients in group I while in group II good results were obtained in only 75% of the patients. The excellent digestive tolerance and the absence of untoward side effects situated irritren as clearly superior to indomethacin. The drug appeared as most useful especially in reactivated arthritic diseases.

Adult↗