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Biomedical subjects

C Dive

Publications and source records attributed to C Dive.

At least 145 records · Page 8Linked to original sources
PubMedDate not supplied

[Chronic pancreatitis and pancreatic cancer. An often difficult differential diagnosis].

A retrospective study of 101 patients whose final diagnosis was chronic pancreatitis (N = 40) or pancreatic cancer (N = 61) aimed to test the respective values of clinical symptoms, laboratory tests, ultrasonography, computerized tomography and endoscopic retrograde cholangiopancreatography for screening of pancreatic lesions and for differential diagnosis. The diagnosis of chronic pancreatitis was found uncertain or erroneous in 7 out of the 40 patients and the diagnosis of pancreatic cancer in 10 out of the 61 patients. The difficulties of differential diagnosis were related to three factors: clinical presentation of some cancers resembling that of chronic pancreatitis, presence of pancreatitic calcifications in some cancers and misinterpretation of pancreatic cavities as cysts or as tumour necroses.

Aged↗
PubMedDate not supplied

[Is jaundice a cause of error in the interpretation of CA 19-9 blood levels?].

Serum CA 19-9 has been proposed as a tumour marker for pancreatic cancer (PC). However, false positive results are seen in sera of patients with benign jaundice. The CA 19-9 assay was performed by a solid state radioimmunoassay in 86 icteric patients (total bilirubin greater than 2 mg/dl). 24/86 had PC (12 men, 12 women, mean age 74 years) and 62/86 had benign jaundice (29 men, 33 women, mean age 56 years; cirrhosis: n = 20, angiocholitis: n = 21, hepatitis: n = 21). At a cut-off level of 60 U./ml, for detecting icteric PC, sensitivity was 83%, and specificity was 79%. At 120 U./ml, sensitivity was 79%, but specificity was increased to 92%. We conclude that 21% of patients with benign jaundice had a CA 19-9 level greater than 60 U./ml, and using a CA 19-9 level of 120 U./ml, the specificity of the test to detect icteric PC was increased, with little decrease in the sensitivity.

Aged↗
PubMedDate not supplied

[Risk of recurrence of colorectal polyps following endoscopic resection].

From 1976 to 1985, 1063 patients (614 men, 449 women, mean age: 63 years) underwent the excision of 1887 adenomatous or villous colonic or rectal polyps. Regular controls by barium enema or total colonoscopy have been proposed to these patients. A first control, performed in 715 patients (67%) after a mean of 27 months, revealed the presence of polyps in 162 of them (23%). A second control performed in 331 of the 535 controllable patients (61%), was positive (presence of polyps) in 82 of them (24%). During the follow-up period, 16 cancerous lesions were observed. Comparing the initial status of the patients with the results of the different controls, 3 risk factors for developing a new colonic or rectal polyp emerged: 1) male sex, 2) the presence of multiple lesions at the initial examination, 3) a recurrence at a previous control.

Adult↗
PubMedDate not supplied

Single dose ranitidine: influence of the time of administration on gastric acidity in normal subjects and in patients with duodenal ulcer.

Using ambulatory 24 hour pH monitoring, intragastric acidity was measured in 6 healthy volunteers and 8 patients with duodenal ulcer. According to a latin square design each patient was randomly assigned to receive placebo, 300 mg ranitidine at 19.00 h or 300 mg ranitidine at 22.00 h, on three separate occasions. Validation of the method was achieved by comparing the values indicated by the intragastric electrode and the pH of simultaneously aspirated gastric juice (y = 0.87x + 0.66, r = 0.93). Comparing the area under the curve of intragastric hydrogen ion activity, as well as the percent of time less than pH 5, we found a better inhibition of nocturnal acidity (20.00 h-08.00 h) with 19.00 h ranitidine than with ranitidine administered at 22.00 h (p less than 0.01). By contrast, there was no significant difference in diurnal acidity between both ranitidine regimens and placebo.

Adult↗