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Biomedical subjects

C Diehm

Publications and source records attributed to C Diehm.

At least 127 records · Page 7Linked to original sources
PubMed1983

[Calcium antagonists for the treatment of Raynaud's phenomenon].

The effectiveness of a new, nifedipine-like calcium antagonist (Bay K 9320) on the severity and frequency of episodic digital vasospasms was studied in a randomized double-blind trial of 24 patients (10 women, 14 men) with Raynaud's phenomenon. During the winter months the patients took one tablet three times daily for three weeks, each tablet either containing 20 mg of the calcium antagonist or a placebo. Three patients had collagen disease, 21 a primary form of Raynaud's phenomenon. Subjective improvement was reported by nine of twelve patients receiving the drug, while no improvement occurred in nine patients on the placebo. Light-plethysmography demonstrated under calcium antagonist treatment a reduction in the cold-provoked acral blood flow decrease more than four-fold compared with the unchanged value in the placebo group.

Adult↗
PubMed1983

[Effect of atenolol and nitroglycerin ointment on exertion tolerance in coronary disease].

In a randomized, placebo-controlled double-blind cross-over study the effect and duration of effect of 2% nitroglycerin ointment (2 cm/m2 body surface) and 50 mg atenolol, as the only drug or the two in combination, were tested on 16 patients with coronary heart disease. Heart rate at rest and on exercise rose significantly for up to 3 1/2 hours (P less than 0.01) after application of the nitroglycerin ointment. Systolic blood pressure at rest and five minutes after exercise was significantly reduced (P less than 0.01), while on exercise there was no significant difference from the control value. Pressure X heart rate product was significantly raised over the initial value up to 3 1/2 hours after application, at maximal exercise (P less than 0.05), while after atenolol there was a highly significant reduction compared with the placebo (P less than 0.01), even after six hours. S-T depression was reduced at maximal comparable exercise level by 49% after atenolol, 52% after nitroglycerin ointment and 76% after combination of the two (P less than 0.05). Exercise tolerance was on average increased for 1 1/2 hours after atenolol by 36%, after nitroglycerin ointment by 58% and after the combined application by 84%, compared with the placebo (P less than 0.01). In the latter (combination) group the pressure X heart rate product was definitely below that of the nitroglycerin ointment group. Thus additional administration of 50 mg atenolol can decrease the pressure X heart rate product after application of nitroglycerin ointment, at the same time increasing exercise tolerance and reducing the degree of S-T depression.

Aged↗
PubMed1983

Effect of prolonged exercise on serum lipids and lipoproteins.

It has been shown that physical exercise lowers serum triglyceride levels and may increase high density lipoprotein-cholesterol levels. Understanding of the mechanisms responsible for these beneficial adaptations is still incomplete. Twenty-six men, who played soccer continuously for 64 hours to establish a world's record, were monitored for acute changes in lipid metabolism. Food intake was determined before and during the exercise period. Blood specimens were taken before and repeatedly during the match for the measurement of triglycerides (TG), total cholesterol (CH), glycerol, apolipoprotein A-I (apoA-I), and cholesterol in various lipoprotein fractions (quantitative lipoprotein electrophoresis). During exercise TG levels decreased from 116 +/- 26 to 66 +/- 13 mg/dL and CH from 180 +/- 22 to 135 +/- 25 mg/dL. Both TG and glycerol showed an initial increase followed by a continuous decrease. Alpha-CH increased by 19% whereas beta-CH and pre-beta-CH decreased markedly (39% and 78%, respectively). In contrast to alpha-CH, apo A-1 fell only slightly by 10%. These results indicate that the effect of chronic exercise on lipids and lipoproteins can be mimicked by acute prolonged exercise. Similar mechanisms may be involved in these adaptations. Moreover, the extreme length of physical exertion substantially lowered CH.

Adult↗
PubMed1983

Isosorbide dinitrate ointment in Raynaud's disease.

In a double-blind, cross-over study the efficacy of isosorbide dinitrate (ISDN) ointment was studied in 12 patients (eight men, four women) with vasospastic Raynaud's phenomenon during the winter. ISDN (200 mg) and placebo respectively were applied to the fingers three times a day for 3 weeks. The efficacy of the drug was judged by patients' reports on the number and duration of Raynaud's attacks, measurements of digital systolic pressures (Doppler method), and photoplethysmography of the fingers before and 3 min after local cooling in ice water. No difference in severity or duration of vasospastic attacks was found in patients treated with ISDN or placebo. There was only a slight, nonsignificant increase (+15%) in digital systolic pressure and amplitudes of digital pulse in the ISDN group. It was concluded that topical ISDN ointment seems to be ineffective for patients with Raynaud's phenomenon.

Blood Pressure↗
PubMed1983

[Effects of metoprolol on the peripheral circulation in patients with peripheral vascular disease].

Up to now betablockers were regarded as relatively contraindicated in patients with peripheral vascular disease (PVD). The effects of metoprolol were studied in hypertensive patients (stage I, WHO) with PVD of pelvic and thigh type (stage II according to Fontaine). An initial dose of 100 mg metoprolol followed by 100 mg 90 min after the first oral administration, twice a day was administered for 8 weeks. Blood pressure decreased from 181/105 to 163/96 mm Hg. Pulse rate was lowered from 72 to 68/min (p less than 0.001). Estimated doppler pressure in the posterior tibial artery decreased from 123 to 119 mm Hg. Venous occlusion plethysmography showed a slight but not significant decrease at rest and during reactive hyperemia. During long-term treatment the pain-free walking distance increased significantly from 225 to 348 m. No side effects were seen. Thus, metoprolol as a beta 1-selective betablocker is not contraindicated in patients with intermittent claudication.

Arterial Occlusive Diseases↗
PubMed1981

[Peripheral arterial vasoocclusive disease: no absolute contraindication to beta receptor blockers (author's transl)].

An initial dosis of 40 mg followed by 40 mg propranolol (Dociton) t.i.d. for 4 weeks was administered to 16 hypertensive patients with manifest arterial vasoocclusive disease of the pelvic and thigh type (stage II according to Fontaine). Blood pressure decreased 90 minutes after the first oral administration from 174/106 to 155/93 mm Hg. Cardiac frequency was lowered significantly from 75 to 66/min. Occlusion plethysmography and Doppler pressure estimation were not changed significantly either in the acute nor in long-term assessment. The painfree walking distance remained constant 90 minutes after propranolol initially (baseline value 230 m, after 90 minutes 220 m). It rose to 330 m after two weeks and to 350 m after four weeks. Use of beta receptor blocker in arterial vasoocclusive disease is thus not contraindicated, at least as far as stage II is concerned.

Arterial Occlusive Diseases↗
PubMed1981

[Ambulant treatment of hypertension with cardiotensin (author's transl)].

A fixed combination preparation consisting of a betablocker and diuretics was tested in 25 outpatients suffering from essential hypertension grades I and II (WHO). The raised blood pressures of the placebo phase fell highly significantly to normal values in th course of the 8 weeks' treatment. The ergometric load testing under standardized conditions showed a significant reduction of blood pressure increase, a significant rise in load capacity, and a decrease in the pressure rate product. Apart from the increase in serum acid in one case, no clinically relevant changes in the laboratory values were observed. Tolerance was good. The side effects mentioned by 10 patients were mild and did not influence the course of treatment. Patient compliance, measured twice in th course of the trial by means of urine fluorescence, was very high (95%).

Adult↗
PubMed1981

Plasma C-peptide and insulin in trained and untrained subjects.

Plasma insulin and C-peptide were simultaneously determined under various conditions in 11 endurance-trained athletes and 12 nonathletes. Both groups performed an exhaustive ergometer test and an endurance test with 38% of the maximal achieved work load for 45 min. An intravenous glucose tolerance test was also performed. In the basal state, athletes had low plasma insulin and C-peptide concentrations. During exercise, insulin and C-peptide decreased similarly in both groups. In the recovery period, insulin and C-peptide rose within a few minutes. There were differences between the extent as well as the time course of this "rebound" effect after exhaustive or endurance exercise that might be related to glucose alterations. The insulin response but not the C-peptide response after glucose injection was blunted in trained subjects. Results indicate that basal plasma insulin concentrations are lower in athletes due to reduced insulin secretion. During exercise, insulin secretion is diminished independent of the training state. The blunted response of insulin after glucose administration in athletes is due to an enhanced plasma clearance.

Adult↗
PubMed1980

[Pharmacotherapeutical action on arteriosclerotic vascular diseases with benzarone (author's transl)].

We report the results of a pilot study to evaluate the therapeutical efficiency of Benzarone in a time span of four weeks in 11 male patients with intermittent claudication. Numerous experimental data indicate that there was a statistically significant increase of painless walking distance and a statistically significant decrease of plasma uric acid, cholesterol and triglycerides. Coagulation analyses furthermore show an increase of the factor VIII activity and the plasminogen levels. For the first time, positive results were shown with Benzarone in patients with intermittent claudication.

Arteriosclerosis↗
PubMed1980

Exercise-induced release of pancreatic polypeptide and its inhibition by propranolol: evidence for adrenergic stimulation.

Pancreatic polypeptide (PP) has been considered to be predominantly under cholinergic-vagal control and may therefore serve as an indicator of vagal tone. We found similar basal plasma concentrations of PP in athletes with bradycardia and in untrained subjects. We further observed that physical exercise--an adrenergic situation--induces a several-fold rise in PP plasma concentration. Maximal plasma PP levels correlated positively with maximal blood pressure. The exercise-induced rise of PP was completely abolished by propranolol. These findings suggest that stimulation of the adrenergic system releases PP and that therefore plasma PP concentrations cannot be used to determine cholinergic-vagal activity.

Adult↗