Biomedical subjects

C Di Massimo

Publications and source records attributed to C Di Massimo.

21 records · Page 2Linked to original sources

PubMed1990

Effect of exogenous hydrogen peroxide on human erythrocytes.

Circulating erythrocytes are drastically susceptible to peroxidative reactions. To examine the extent of the damage induced by exogenous H2O2 we limited the catalase activity in order to study the extent of lysis, the lipid peroxidation and namely the behaviour of membrane micro-viscosity. Our data showed that the erythrocytes can efficiently scavenge exogenous H2O2 without significant damage of the cells and/or their membranes. These findings could confirm the important role of the erythrocytes as extracellular-antioxidant defense.

Erythrocyte Membrane↗

PubMedDate not supplied

Erythrocyte membrane fluidity in subjects affected with reversible ischemic attacks (RIA).

It is well recognized that in subjects with cerebrovascular disease (CVD), changes in hemorheological properties may occur in about 50% of the patients. This paper concerns a study on microhemorheological perturbations of the erythrocyte membranes in a group of 20 RIA's patients, treated with Pentoxifylline. At the admission of the subjects to the study a trend to an increased whole blood viscosity and erythrocyte aggregation was associated to alterations of membrane fluidity analyzed by means of the fluorescent probes in the patients with respect to the controls. At the end of pharmacological treatment and wash-out, our data indicate a clear modification in erythrocyte membrane which results improved. Our results underline how the improvement of the erythrocyte membrane fluidity, induced by pentoxifylline, is a basic factor of blood flow in the microcirculation.

Erythrocyte Membrane↗

PubMedDate not supplied

In vitro effects of alloplastic biomaterials on the functional features of human erythrocytes and platelets.

In vitro experiments were performed to evaluate the biocompatibility of metallic plates used in reconstructive maxillofacial surgery, analyzing the effect of titanium, nickel-chromium-molybdenum and stainless steel plates on some functional features of human erythrocytes and platelets, being rheological properties and platelet responsiveness pivotal for the perfusion of the tissues surroding the metallic implants. Our data underline that the tested plates are not responsible for significant alterations of the erythrocyte rheological features and of platelet reactivity.

Biocompatible Materials↗