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Biomedical subjects

C Delcour

Publications and source records attributed to C Delcour.

At least 91 records · Page 5Linked to original sources

Subclavian vein thrombosis: a frequent complication of subclavian vein cannulation for hemodialysis.

Subclavian vein cannulation was suggested as a temporary vascular access for hemodialysis since one of its advantages was considered to be no damage to blood vessels. As we observed six patients with symptomatic subclavian vein thrombosis among 148 patients having received subclavian vein cannulation for hemodialysis, we systematically performed subclavian venogram in 42 asymptomatic patients selected on the basis of a history of previous subclavian vein cannulation. Venograms were performed 15.7 +/- 8.9 months after the removal of the last catheter. Eight patients (19%) had complete thrombosis or severe stenosis of the subclavian vein while six patients (14%) had minimal luminal defects. Considering together the 48 patients, the group with thrombosis or severe stenosis (group 1, n = 14) was compared with the group with minimal defects or normal venograms (group 2, n = 34). In group 1, as compared with group 2, there were more female (64% vs 32%, p = 0.02), more cannulations per vein (1.87 +/- 0.35 vs 1.32 +/- 0.08, p less than 0.05) and more cumulative days of cannulation per vein (35.1 +/- 7.9 vs 24.4 +/- 1.1, p less than 0.001). No difference between the two groups was seen for the number of catheter infections, the number of catheters with poor flow or obstruction, the coagulation screening of the patients or the time-length between the removal of the last catheter and the venogram study. Two of the initially asymptomatic patients developed later on clinical problems related to the subclavian vein thrombosis. We conclude that the subclavian vein cannulation leads to significant damages of the vessels, excluding a whole arm, for future vascular access in some patients.

Catheterization↗

[Venous exploration of impotence of vascular origin].

Vascular origin accounts for more than 25% of cases of disturbances of erection. Venous pathology may explain the majority of erectile dysfunctions in patients with normal arterial anatomy. We have performed cavernography in 115 patients with monitoring of intracavernous pressure. Nocturnal plethysmography was recorded in all cases to prove the organic etiology of the erectile dysfunction. Cavernography was realized after puncture of both corpora cavernosa by two microcatheters (19-21 G). The intracavernous pressure was recorded through 1 of them and the contrast medium infused through the other. The contrast medium is infused at a rate of 80-120 ml/min. until the penis appears erect. The simultaneous recording of the intracavernous pressure then showed a rapid increase of the pressure curve followed by a stabilization at greater than or equal to 90 mHg. The flow to maintain the erection reach 1/3 of the flow needed to induce the erection. The venous leak is characterized by the absence of erection, no increase in intracavernous pressure and a rapid opacification of the vein. Artificial erection induced in impotent men allows to classify patients with vascular organic impotence into three categories: those with pure arterial insufficiency, those with pure venous leak, and patients with both.

Adolescent↗

Intra-arterial chemotherapy of infiltrative bladder carcinoma.

Twenty patients with untreated invasive high stage or high grade transitional cell carcinoma of the bladder have been treated by bilateral intra-arterial hypogastric injection of adriamycin. A total of 160 mg of adriamycin were injected during the procedure which was repeated once 3-4 weeks later. Eleven patients received two full courses of chemotherapy. In 4 patients, complete response with disappearance of all tumoral lesions was observed and in 1 patient, partial tumor regression was apparent. One patient died from pulmonary disease. Five patients received only a partial treatment because of technical difficulties, and selective catheterization was impossible in 4 because of severe arteriosclerotic lesions. No response was seen in those cases. Although this new therapeutic modality remains to be fully evaluated, preliminary results appear most encouraging since intra-arterial chemotherapy can be used safely and is effective in patients with invasive bladder carcinoma.

Aged↗

Sonographic features of portal vein thrombosis.

The ability of real-time sonography to demonstrate the liver venous network is well documented. Sonographic features of 21 cases of unsuspected portal vein thrombosis, detected by a screening sonography of the upper abdomen and subsequently confirmed by computed tomography, angiography, or surgery, are discussed. Sonographic features of portal vein thrombosis were an echogenic thrombus within the lumen of the vein (67%), demonstration of portal vein collateral circulation (48%), enlargement of the thrombosed segment of the vein (38%), and the so-called cavernomatous transformation of the portal vein (19%). Echogenic endoluminal thrombi were observed with the same incidences in malignant and benign disease. Sonography, unlike angiography, was unable to characterize neoplastic thrombi; only the combination of an echogenic thrombus and an adjacent hepatic mass was strongly suggestive of malignancy, especially hepatoma. The extensive use of sonography as a screening test in upper abdomen pathology will probably improve the detection of portal vein thrombosis, a diagnosis until now considered rare.

Adult↗

Investigation of the venous system in impotence of vascular origin.

Vascular pathology is responsible for about 25% of cases of male impotence. Pudendal arteriography has been the object of numerous publications. Venous conditions explain the majority of erectile dysfunctions in patients with normal arterial anatomy. We have performed cavernography in 30 patients, with monitoring of intracavernous pressure and flow measurement. Cavernograms allowed study of the corpora cavernosa and the venous drainage. Cavernography not only helps in understanding the mechanism of erection but also is essential to the successful treatment of pathologic venous drainage.

Adult↗

Cavernometry-cavernography: its role in organic impotence.

The intracavernous pressure necessary to produce a passive erection was recorded in 35 patients suffering from impotence. Among these patients, 5 presented psychogenic impotence. The intracavernous pressure was also recorded at rest during inflow and in the state of erection. The 5 psychogenically impotent patients had passive erections with a flow of 80-120 ml/min. 18 patients suffering from organic impotence developed passive erections at a flow of 80-120 ml/min, while the remaining 12 men needed a flow between 160 and 300 ml/min with visualization of a venous leak. The intracavernous pressure varied between 90 and 110 mm Hg in the state of erection. Artificial erection, induced in impotent men, allows to classify patients with vascular organic impotence into three categories: those with pure arterial insufficiency; those with pure venous leak, and patients with both.

Adult↗

[Radiologic and hemodynamic studies of sexual impotence of vascular origin].

Vascular pathology is responsible for about 25% of male impotence, the arterial investigation is now classical. In our experience a great number of patients showed a normal arterial condition, requiring further venous exploration. Cavernographies and pressure flow dynamics were used to evaluate 45 patients. The cavernograms allowed visualization of structural abnormalities within the cavernous tissues and their venous drainage. The heparinized and diluted contrast medium is infused at 80 to 120 ml/minute until the appearance of an erection, in normal condition the intracavernous pressure rise at greater than or equal to 80 mmHg as long as the erection last. The venous leak is characterized by the absence of erection, no increase of the intra-cavernous pressure and a rapid opacification of venous plexus under a normal perfusion flow.

Adult↗