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Biomedical subjects

C Del Campo

Publications and source records attributed to C Del Campo.

At least 37 records · Page 2Linked to original sources
PubMed1994

Use of a pericardial xenograft patch in repair of resected retrohepatic vena cava.

Complete surgical excision of malignant tissue is mandatory for the long-term survival of patients with hepatic metastases from colorectal carcinoma. Involvement of the inferior vena cava (IVC) may prevent this resection. The authors describe the case of a 64-year-old man who underwent right hepatic lobectomy for metastases from colorectal carcinoma. Partial involvement of the IVC by tumour necessitated resection of a large portion of its wall. Venous continuity was re-established with a large bovine pericardial patch. At follow-up 2 years after the repair, the IVC was still patent and the vessel diameter was normal. On enhanced computed tomography, the patch was indistinguishable from the native vessel.

Adenocarcinoma↗
PubMed1993

Synthesis and antitumor activity of pyrido-amsacrine analogues and related compounds.

The pyrido derivatives of amsacrine [4'-(9-acridinylamino) methanesulfon-m-anisidine] were prepared and evaluated in the L1210 leukemia system. Almost all the pyrido analogues were tighter DNA-binding ligands than the corresponding amsacrine compounds. The significant inhibition of L1210 produced by pyrido-acridan-7-ones demonstrates that the anilino side chain is not essential for activity, although most of the compounds did not have improved activity compared with amsacrine.

Amsacrine↗
PubMed1993

Vena cava bypass with stented polytetrafluoroethylene bifurcated grafts. A report of 2 cases.

Severe stenosis or occlusion of either the superior or the inferior vena cava requires surgical bypass grafting in a selected group of patients. When the obstruction extends into the major tributaries, a bifurcated graft becomes necessary. We present the cases of 2 surgically treated patients, each of whom received a stented polytetrafluoroethylene bifurcated graft constructed at the time of the operation. Symptoms disappeared post-operatively in 1 patient and abated in the other. Both grafts became occluded within 1 year; however, that was sufficient time for collateral venous circulation to develop, enabling both patients to respond well to conservative therapy. We conclude that stented polytetrafluoroethylene bifurcated grafts may be suitable for selected patients as a bridge until collateral veins can form. The development of more compliant venous grafts may provide even more favorable results.

Adult↗
PubMed1992

Prosthetic replacement of the superior vena cava with a custom-made pericardial graft: an experimental study.

Prosthetic replacement of the vena cava has been disappointing, mainly because of the hemodynamic characteristics of the venous system and the physical properties of the prostheses used. Spiral grafts constructed with autogenous saphenous vein have been the most successful prostheses to date, but their use is limited to replacement of short segments, and intraoperative construction is time consuming. The authors report their experience with a graft constructed of extra-thick bovine pericardium (PX) and surgical staples. Externally stented polytetrafluoroethylene (PTFE) was used as a control. The superior vena cava was replaced in 13 ewes; PTFE was used in 6 (group 1) and PX in 7 (group 2). Mean follow-up was 15 +/- 8 months for group 1 and 13 +/- 8 for group 2. Cumulative graft follow-up totalled 4612 graft-days. There was one graft occlusion in each group. Patency rates (80%) were similar for the two groups. Histologic changes in pericardial grafts were more marked but did not influence patency. This study reports the longest experimental follow-up (maximum 23 months) and graft patency to date for replacement of the superior vena cava. Both types of graft performed excellently.

Animals↗
PubMed1991

Prospective evaluation of a totally implantable drug delivery system. Improved results at 4-year follow-up.

Totally implantable drug delivery systems have facilitated chemotherapy in cancer patients. The incidence of complications has been acceptable but not optimal. A series of 140 consecutive implants over a 4-year period is presented. The total follow-up was 41,185 days. Reversible obstruction was present in 12.8% of portals. The infection-erosion rate was 4.2%; only 6.3% of patients required removal of the system because of failure. In the last 111 patients only one device failed (0.9%). The reasons for these improved results are analysed, and recommendations are made to improve the current management of these devices.

Adult↗
PubMed1989

Juxtarenal aortic aneurysm after successful repair of ruptured infrarenal aneurysm.

Eight months after successful repair of a ruptured infrarenal aneurysm, a 50-year-old hypertensive male patient was found to have a 2nd aneurysm restricted to the juxtarenal segment of the aorta, and not in continuity with the infrarenal lesion. While there have been reports both of true aneurysms arising independently in the abdominal (infrarenal) and thoracic (suprarenal) aortic segments, and of false aneurysms arising secondary to abdominal aortic repair (at the suture line or as dilatations of residual aneurysmal tissue), we believe our case unusual in that the new aneurysm was a discrete and "true" thoracoabdominal dilatation arising just above the renal arteries and terminating just below the superior mesenteric artery. This strictly juxtarenal dilatation conforms better to a descriptive pattern for atherosclerotic occlusive disease than it does to the standard scheme for classifying thoracoabdominal aortic aneurysms.

Journal Article↗
PubMed1985

Mediastinal packing for refractory nonsurgical bleeding after open-heart surgery.

Patients with infective endocarditis and disseminated intravascular coagulation may require emergency valve replacement because of acute hemodynamic decompensation. After cardiopulmonary bypass is discontinued, nonsurgical hemorrhage, refractory to conventional treatment, may occur. The author describes a technique of mediastinal packing for temporary control of bleeding until the coagulation disorder can be corrected. The pack can be removed transcutaneously without reoperation. This method should be used only when all other approaches have failed to achieve hemostasis.

Anticoagulants↗
PubMed1985

Pulmonary embolectomy: a review.

Massive pulmonary embolism continues to be a major cause of death in spite of improved medical therapy. Only a small number of patients with pulmonary embolism refractory to medical treatment are referred for pulmonary embolectomy. A literature review of patients with massive pulmonary embolism treated by pulmonary embolectomy showed that the operation was highly successful in those who were unlikely to survive with other modes of therapy. Specific indications and management are outlined on the basis of these cumulative data.

Cardiopulmonary Bypass↗
PubMed1985

Simplified insertion of the Port-A-Cath implantable drug-delivery system.

The increasing frequency with which antineoplastic drugs are being used demands improved vascular access for their administration. Venous access through implantable catheters facilitates treatment when veins are no longer available. Totally implantable catheters of the Port-A-Cath type are preferred because they give better performance and cosmetic results, and are more convenient for the patients. The flexibility of these catheters makes their introduction difficult. The author describes a simplified technique, using a commercially available introducer that has been used satisfactorily in thousands of pacemaker implantations. The author has used this technique routinely with a 50% decrease in operative and fluoroscopy time and without complications.

Antineoplastic Agents↗