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Biomedical subjects

C Deckers

Publications and source records attributed to C Deckers.

51 records · Page 3Linked to original sources
PubMed1972

A comparative study of the proteins of rat plasma, liver and hepatoma by agarose immunoelectrophoresis.

A convenient and selective microtechnique, agarose immunoelectrophoresis, was applied to a comparison of the antigens in rat liver and plasma, and in primary hepatoma induced in male Fischer strain rats with N-2-fluorenylacetamide or N-hydroxy-N-2-fluorenylacetamide. Of the many soluble proteins antigenic in this system, 3 were singled out for detailed study. The albumin in liver and hepatoma had a higher mobility than that in plasma. Extraction of the soluble fraction of rat liver with ether, or treatment with absorbing charcoal, yielded an albumin band with a mobility identical to that in plasma, suggesting that liver albumin carries absorbed molecules with electronegative charges. The transferrin arc from liver, plasma and hepatoma had identical mobility. One protein with low mobility was present in higher concentration in the soluble liver fraction of male than of female rats, but it was reduced in hepatoma of male rats. The "h(2)" proteins of liver were found in the cathodic region as 5 arcs, some of which were reduced, while others were not detectable in hepatoma.

Absorption↗
PubMedDate not supplied

Laboratory rat associated outbreak of haemorrhagic fever with renal syndrome due to Hantaan-like virus in Belgium.

Hantaan-like virus was identified as the cause of three cases of acute renal failure in staff handling laboratory rats on a Belgian university campus. Serological studies revealed infected rat strains at different sites on the campus and evidence of past and recent infections in 39 staff members and of infection in 50% of exposed staff. Hantaan-reactive antibody was very rare in control populations. Staff or rats at three other Belgian institutions had no signs of infection. The origin of the virus was not identified. Infected rats have been removed. These are the first confirmed cases, outside East Asia, of human illness due to rat-borne Hantaan-like virus, and of infection in laboratory rats. Surveillance of rat colonies is also recommended in countries which, like Belgium, have no previously recognised cases of haemorrhagic fever with renal syndrome.

Acute Kidney Injury↗