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Biomedical subjects

C Debru

Publications and source records attributed to C Debru.

12 recordsLinked to original sources

Helmholtz and the psychophysiology of time.

After having measured the velocity of the nervous impulse in the 1850s, Helmholtz began doing research on the temporal dimensions of visual perception. Experiments dealing with the velocity of propagation in nerves (as well as with aspects of perception) were carried out occasionally for some fifteen years until their final publication in 1871. Although the temporal dimension of perception seems to have interested Helmholtz less than problems of geometry and space, his experiments on the time of perception were technically rather subtle and seminal, especially compared with experiments performed by his contemporaries, such as Sigmund Exner, William James, Rudolf Hermann Lotze, Ernst Mach, Wilhelm Volkmann, and Wilhelm Wundt. Helmholtz's conception of the temporal aspects of perception reflects the continuity that holds between psychophysiological research and the Kantian philosophical background.

Germany↗

Preconceived ideas in the classification of leukemia.

General biological classifications have theoretical aims regarding the natural order of things. Classification in pathology has basic pragmatic aims regarding diagnosis, prognosis and treatment. In history, leukemia classifications were mainly (but not exclusively) based on classification of normal cells. Clinical data were introduced mainly secondarily. For a long time, no treatment was available. Two questions are asked: might classification of leukemia help to understand the disease's mechanisms; might better classification eliminate unclassifiable leukemias?

Erythrocytes↗

A particular form of chemotaxis: necrotaxis. An historical view.

Necrotaxis has been defined as chemotaxis toward a dying cell. Chemotaxis, since its discovery in 1888, has been the subject of controversy, both as to its reality and as to an appropriate definition such as directional movement induced by chemical stimuli. Microcinematography has settled both questions. The necrotaxis phenomenon was first described in 1930, then denied and questioned. It was experimentally created, and defined in 1964, after the introduction of new micro-irradiation techniques (UV, laser). As a technique, necrotaxis is particularly useful in the study of chemotaxis. As a biological phenomenon, necrotaxis plays an important role in physiology and pathology.

Animals↗

Is symmetry conservation an unessential feature of allosteric theory?

The role of symmetry in allosteric theory is historically and philosophically revisited. The (at least approximate) symmetry of the hemoglobin binding curves led investigators to postulate a similar symmetry or equivalence in the binding sites, which meant a symmetrical arrangement of the hemes and of the whole molecule. Later Monod introduced the concept of symmetry conservation to describe allosteric behaviour. It is shown that this postulate does not really belong to the framework of allosteric theory as it was developed in thermodynamical terms. Symmetry, however, still plays a role at levels in the underlying mathematical theory of binding and linkage in biological macromolecules.

Allosteric Site↗

Increase of paradoxical sleep episodes after electrical stimulation of the lateral and third ventricles in the rat.

Electrical stimulation (0.3 mA in intensity, 80 Hz in frequency, 0.7 ms in signal duration) applied at 17.00 h in the lateral and third ventricles induced a significant increase of nocturnal paradoxical sleep (PS). This effect persisted for two consecutive days in both cases. Non-specific aspects involved in this effect are discussed and the results are commented on in terms of humoral processes and possible control of pineal gland activity.

Animals↗

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Biochemistry↗