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Biomedical subjects

C Davis

Publications and source records attributed to C Davis.

At least 145 records · Page 8Linked to original sources
PubMed1997

Nightmares, dreams, and schizotypy.

The theory that psychosis and dreaming share some common underlying mechanism finds support in the observation that chronic nightmare sufferers are at increased risk for psychopathology. We examined this connection in a large general population sample, administering a battery of psychosis proneness and other personality scales, together with a nightmare distress scale; participants also answered a single question on pleasurable mood associated with dreaming. In addition, they completed the Bem Sex Role Inventory, to reinvestigate previously observed gender differences in nightmare susceptibility. It was found that, among the psychosis proneness scales, the best predictor of nightmare distress was STA, a mostly cognitive measure of schizotypy; this was true even after allowing for a strong influence in the data of general neuroticism. Other aspects of psychosis proneness--e.g. anhedonia--were unrelated to nightmares. However, sex and sex role differences did make a significant contribution, self-confessed feminine females and masculine males reporting, respectively, the highest and lowest nightmare distress. For schizotypy it was further shown that relationships were not confined to the nightmare experience; high (STA) schizotypes also significantly more often reported enjoyable dreaming. It was concluded that a unifying theme explaining the data is the schizotype's greater imaginativeness, which can have both positive and negative expression in sleep and consciousness.

Adolescent↗
PubMed1997

Personality factors related to the prevalence of somatic symptoms and medical complaints in a healthy student population.

Previous research in somatization has identified strong positive relationships between this variable, and both neuroticism, and depression. Many studies, however, are limited by a cross-sectional approach, correlational analyses, and/or the restriction to clinical (psychiatric or medical) populations. The present investigation prospectively compared the relationships between neuroticism, depression, and somatic symptoms in a healthy student sample. As predicted, neuroticism and depression were significantly and positively related to symptom reporting. The results of a multiple regression analysis indicated that depression contributed significantly to the variance in symptom-reporting even after controlling for the effects of neuroticism. This finding suggests the importance of mood state in the experience of somatic symptoms. However, this influence is not independent of the trait neuroticism. The results of this study also indicated that females reported significantly more symptoms than males, and gender-specific relationships are discussed.

Adult↗
PubMed1997

Eating disorders and hyperactivity: a psychobiological perspective.

OBJECTIVE: To review the eating disorder research investigating the psychobiological connections between self-starvation and high-level exercising, including both animal experimentation and clinical field studies. In recent years it has been proposed that physical activity plays a central role in the pathogenesis and progression of the eating disorders-in particular, anorexia nervosa. METHOD: A review of research from animal experimentation and from clinical field studies investigating the biological and psychological implications of physical activity and starvation in the pathogenesis of eating disorders. RESULTS: Animal research indicates that physical activity and starvation seem to potentiate one another and that alterations in the serotonergic system may underlie this process. Similar behavioural results have been found in recent clinical studies with eating-disordered patients, which suggests that physical activity plays a more central role in the development and maintenance of the eating disorders than had previously been thought. CONCLUSIONS: The emerging picture is that psychosocial factors seem to provide the most compelling factors in the etiology and onset of the disorder, while biological factors-in most cases induced by severe malnutrition and strenuous overexercising-predominate in the maintenance of the disorder.

Adolescent↗
PubMed1997

Lighting test partnership: Southern California/Kaiser Permanente lighting study.

Energy-reduction conservation efforts are in the interest of any well-run health care facility. Energy-efficient lighting and lighting systems can deliver significant energy savings while maintaining optimum lighting levels. This document is a result of a lighting study conducted by Southern California Edison's Customer Solution's Group and Kaiser Permanente to help resolve some issues relating to future lighting projects. In particular, specular reflectors as an issue was addressed.

California↗
PubMed1997

Interviews with men with prostate cancer about their self-help group experience.

This study reports on the results of semi-structured interviews with 12 men involved in prostate cancer self-help groups in three Canadian cities. Overall, participants reported their group involvement to be helpful, especially in terms of accessing information. Additional benefits included finding commonality with others, being able to talk about difficult issues, being productive and accomplishing tasks, advocating to make a difference, and engaging with family members around health issues. We conclude that the recent growth of self-help groups speaks to the challenge inherent for men in dealing with prostate cancer and counteracts tendencies to minimize the suffering which they experience.

Adaptation, Psychological↗
PubMed1997

A new fibre optic sensor for respiratory monitoring.

A new fibre optic plethysmograph has been designed to monitor respiration non invasively. The device incorporates the idea of using thoracic and abdominal belts similar to conventional inductance plethysmography but uses an optical fibre woven into the belts rather than the usual coiled wire. The fibre optic belts incorporate a loop design in the fibre and rely on "macrobending" losses from laser light transmitted down the fibre when the bend radius of the loop changes during respiration. Changes in lung volume are monitored by analysing the relatively large resultant changes in light transmitted through the fibre. The output from the light detector has been interfaced to a computer containing a data acquisition card and the resultant intensity trace is monitored in real time using a virtual instrument created using LabVIEW graphical programming. Preliminary results suggest a highly sensitive system capable of detecting small changes in lung volume using a technique which is not susceptible to electrical noise and which is electrically safe.

Adult↗
PubMed1996

The problem of thrombocytopenia after hematopoietic stem cell transplantation.

Thrombocytopenia after hematopoietic stem cell transplantation (HSCT) is associated with an increased risk of bleeding and utilization of significant resources. This review presents an analysis of risk factors associated with delayed platelet engraftment. The retrospective analysis included 1,468 recipients of autologous or allogeneic transplants treated between January 1, 1990 and July 1, 1995. Risk factors associated with delayed platelet engraftment after autologous HSCT included use of marrow rather than peripheral blood as the source of stem cells, being transplanted for acute myeloid leukemia rather than other diseases, positive patient serology for cytomegalovirus and the presence of infection post-transplant before engraftment. Risk factors associated with delayed platelet engraftment after allogeneic marrow transplantation included unrelated as opposed to related donor transplants, being transplanted for diseases other than chronic myelogenous leukemia, increased age, onset of acute graft-versus-host disease (AGVHD), male gender, the administration of methotrexate for GVHD prophylaxis and the presence of infection before engraftment. Delayed platelet recovery is associated with decreased survival after both autologous and allogeneic transplants. Management of delayed platelet recovery by transfusion of blood products requires significant medical resources and is of some risk to the patients. Further development of new strategies may safely reduce the need for blood products. These include peripheral blood stem cell transplants (allogeneic and autologous), new algorithms for administering routine platelet transfusions and investigative biological agents for stimulating megakaryocytopoiesis. Further studies may elucidate the cause of increased platelet consumption associated with infection and GVHD.

Adolescent↗
PubMed1996

Individual difference variables that predict response to training in phonological awareness.

The cognitive abilities that predicted growth in response to a 12-week training program in phonological awareness were investigated with a sample of 100 kindergarten children. The children were selected from two elementary schools with historically low achievement in reading. Sixty children received training in both analytic and synthetic awareness skills, and 40 children constituted a no-treatment control group. Pretest measures included assessment of phonological awareness, phonological memory and naming rate, letter knowledge, reading and spelling, and general verbal ability. Growth in phonological awareness was assessed during the middle and at the end of the training period. Hierarchical linear modeling was used to estimate individual growth curves in phonological awareness for children in both the treatment and control groups. Initial comparisons between children in the two groups indicated substantial overall training effects in phonological awareness for children in the treatment group. For children in the training group, the model that best predicted growth in analytic awareness included invented spelling and general verbal ability, while growth in synthetic awareness was predicted best by a combination of invented spelling and rapid automatic naming of digits.

Awareness↗
PubMed1996

The effects of moclobemide on sexual desire and function in healthy volunteers.

Decreased sexual desire is a recognized symptom of major depression (MD). Disturbances in sexual function, although reported in drug = free patients, have more often been viewed as adverse drug effects during antidepressant treatment with established classes of antidepressants (TCA, MAOI, SSRI). However, it is difficult to draw conclusions about the effects of antidepressants on sexual desire and function for two reasons: lack of standardised assessments for sexual function; inability to distinguish depression-related symptoms from drug-induced sexual disturbances. The purpose of this study was to examine the effects of moclobemide (a RIMA antidepressant) on sexual function in healthy male and female volunteers. Sixty male and female volunteers were randomly assigned to either moclobemide 300 mg or placebo for 3 weeks. They were seen at weekly intervals to assess drug compliance and to complete a 10-item sexual function questionnaire (SFQ). In both men and women there were no differences between moclobemide and placebo on measures of sexual desire and function. However, men and women differed in the levels of reported interest and sexual performance.

Adult↗
PubMed1996

Child abuse in Hong Kong revisited after 15 years: characteristics of victims and abusers.

The purpose of this paper was to examine the characteristics of the victims and abusers of child abuse cases on the Child Protection Registry in Hong Kong as of March 1995 and to compare findings with a similar community report of child abuse in Hong Kong conducted approximately 15 years earlier. As of March 31, 1995, there were 457 active cases of child abuse or suspected child abuse (44% male and 56% female) on the computerized Child Protection Registry. Fifty percent of the victims were grade school age children between 7-12, and 62.4% suffered physical abuse. The abusers or suspected abusers were 52% male and 48% female with nearly half (49%) in their thirties. The majority of abusers were married/cohabiting (75%) with only a grade school education (60%). As compared to 1979, there was an increase of sexual child abuse cases, female victims of child abuse, and an increase in male abusers or suspected abusers.

Adult↗
PubMed1996

Bone density in survivors of childhood malignancies.

PURPOSE: The purpose of this study was to assess bone mineralization in survivors of childhood malignancies. PATIENTS AND METHODS: Bone mineral density (BMD) of the lumbar spine was measured in 60 patients aged 5.5-20.1 years (mean, 12.4 years) who had no known disease 1.0-14.5 years (mean, 4.3 years) after completing treatment for a malignancy. The age-normalized BMD findings (Z scores) were correlated with multiple variables, including measures of growth and nutrition, type of malignancy, and various treatments, including use of steroids, methotrexate, or cranial irradiation. RESULTS: BMD was normal in most patients with a mean Z score of -0.28 + 0.14 (+/- SE). Only 8% of the patients were more than 2 SDs below age-matched normal BMD. Weight Z score was the major determinant of BMD Z score. Calcium intake and height Z score were also important variables. CONCLUSIONS: Most survivors of childhood malignancies will not be left with a clinically significant deficit in BMD. Risk factors for diminished BMD include low-weight and low-height Z scores and low calcium intake. Therapeutic interventions are available to address these risk factors in those patients with significantly diminished BMD.

Adolescent↗
PubMed1996

Ethnicity and aged care assessment teams in Queensland.

To examine how functional, medical and psychosocial factors influence the differences in use of community and residential services by Australian-born and ethnic aged persons, all persons (n = 31,737) assessed by aged care assessment teams in Queensland in 1992 and 1993 were surveyed. Subjects were classified as Australian-born, overseas-born in countries where English is the primary language, or overseas-born in countries where English is not the primary language. Factors compared included use of services and residential care both prior to assessment and following assessment, and functional, medical and psychosocial factors. The group with non-English-speaking background were more likely to be both younger and underreferred compared to their proportion in the community. They were more likely to be referred for, and more likely to be recommended for, nursing home placement than the English-speaking groups. They were more commonly referred for assessment because of mental deficit problems, carer stress and/or social isolation, more likely to be diagnosed with dementia and diabetes, and less likely to be diagnosed with respiratory disease and vision disorders. That clients of non-English-speaking background are more likely to be recommended for nursing home placement is probably largely because of more advanced disease at the time of referral and therefore more functional dependence. Aged care assessment teams should increase ethnic communities' awareness of their services, particularly of the benefits of earlier referral.

Activities of Daily Living↗
PubMed1996

Distribution of thiols in microorganisms: mycothiol is a major thiol in most actinomycetes.

Mycothiol [2-(N-acetylcysteinyl)amido-2-deoxy-alpha-D-glucopyranosyl- (1-->1)-myo-inositol] (MSH) has recently been identified as a major thiol in a number of actinomycetes (S. Sakuda, Z.-Y. Zhou, and Y. Yamada, Biosci. Biotech. Biochem. 58:1347-1348, 1994; H. S. C. Spies and D. J. Steenkamp, Eur. J. Biochem. 224:203-213, 1994; and G. L. Newton, C. A. Bewley, T. J. Dwyer, R. Horn, Y. Aharonowitz, G. Cohen, J. Davies, D. J. Faulkner, and R. C. Fahey, Eur. J. Biochem. 230:821-825, 1995). Since this novel thiol is more resistant than glutathione to heavy-metal ion-catalyzed oxidation, it seems likely to be the antioxidant thiol used by aerobic gram-positive bacteria that do not produce glutathione (GSH). In the present study we sought to define the spectrum of organisms that produce MSH. GSH was absent in all actinomycetes and some of the other gram-positive bacteria studied. Surprisingly, the streptococci and enterococci contained GSH, and some strains appeared to synthesize it rather than import it from the growth medium. MSH was found at significant levels in most actinomycetes examined. Among the actinobacteria four Micrococcus species produced MSH, but MSH was not found in representatives of the Arthrobacter, Agromyces, or Actinomyces genera. Of the nocardioforms examined, Nocardia, Rhodococcus, and Mycobacteria spp. all produced MSH. In addition to the established production of MSH by streptomycetes, we found that Micromonospora, Actinomadura, and Nocardiopsis spp. also synthesized MSH. Mycothiol production was not detected in Propionibacterium acnes or in representative species of the Listeria, Staphylococcus, Streptococcus, Enterococcus, Bacillus, and Clostridium genera. Examination of representatives of the cyanobacteria, purple bacteria, and spirochetes also gave negative results, as did tests of rat liver, bonito, Candida albicans, Neurospora crassa, and spinach leaves. The results, which indicate that MSH production is restricted to the actinomycetes, could have significant implications for the detection and treatment of infections with actinomycetes, especially those caused by mycobacteria.

Actinomycetales↗