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Biomedical subjects

C Davidson

Publications and source records attributed to C Davidson.

125 records · Page 7Linked to original sources
PubMed1975

A comparative study of the activity of beta-adrenoceptor antagonists in man.

1. In healthy subjects the plasma concentration of unchanged drug, heart rate response to excerise and attenuation of isoprenaline tachycardia were maximal at one hour after ingestion of a range of doses of propranolol, oxprenolol, practolol, tolamolol, atenolol and metoprolol. 2. There was a within-drug relationship between plasma concentration of unchanged drug and the attenuation of exercise and iosprenaline tachycardia. There was no similar between-drug relationship. 3. There was a similar exponential relationship between oral dose and reduction of exercise tachycardia for all six drugs. 4. The linear relationship between oral dose and antagonism of infused isoprenaline was significantly greater for oxprenolol and propranolol than for the other four drugs. 5. "Cardioselective" activity was the only ancillary pharmacological property which differentiated the activity of these drugs in normal subjects.

Adrenergic beta-Antagonists↗
PubMed1970

The production of mammary carcinomas in rats by 9,10-dimethyl-1,2-benzanthracene and its relationship to the oestrous cycle.

Sprague-Dawley rats aged 50 days were given single oral doses of the carcinogen, DMBA.Rats receiving the carcinogen at the same stage of the oestrous cycle were grouped together and mammary tumour production was compared between these groups.When the carcinogen was given during di-oestrus the mean number of tumours per animal was significantly greater than when it was given at other stages in the oestrous cycle. There was considerable variation in total tumour yield from one batch of animals to another.

Animals↗
PubMedDate not supplied

Attitudes of faculty members of schools of public health toward public service.

Public service has long been considered one of a traditional triad of academic functions--teaching, research, and service. Yet even in schools of public health, where service is purported to be an integral component of the institution's mission, faculty generally do not accord as high a value to service performance or approach it with the same degree of commitment as they do research and teaching. A study was conducted to examine faculty perceptions and attitudes toward the service function and its relationship to teaching and research within schools of public health. The data were taken from a mailed questionnaire survey of 20-30 faculty members in each of 20 schools of public health in the United States. The response rate was 71 percent, or 387 returned questionnaires. Respondents generally felt that the greatest value of service lies in its potential for enhancing the image and prestige of the school, and in the fulfillment of the community obligation of the institution. The possibility that service might bring about improvements in faculty research and teaching, or improvements in health services and public health, was rated significantly lower. Thus, respondents did not view service as useful for its contribution to their own careers or to public health practice as much as they regarded it as a beneficial contribution to the reputation of the institution. This view undermines the traditionally held notion that public service either benefits a particular constituency outside the school or enhances the professional development of faculty members themselves.

Attitude↗
PubMedDate not supplied

General medicine and related medical specialties--consultant survey 1991.

A census of all consultant physicians in England and Wales was carried out on 2 January 1991 by the Royal College of Physicians of London. The total number, 3,573, agreed closely (97%) with the numbers known to the Department of Health (DoH). Of this total, 1,352 were general physicians. Their commonest specialty interests were cardiology, endocrinology, gastroenterology, and thoracic medicine; one-sixth of the geriatricians held posts with some general medical component. In all specialties there is a bulge in the number of consultants aged 40-50. This will lead to a substantial increase in the number of vacancies in the early part of the next century, and will need careful manpower planning. The proportion of women consultants in medical specialties, with perhaps the exception of dermatology, haematology, and geriatric medicine, remains low at 13%. An adequate 'safety net' of junior staff for the care of adult emergencies was present in most main district hospitals at the time of this census.

Adult↗
PubMedDate not supplied

Assessment of cardiopulmonary resuscitation in the membership examination of the Royal College of Physicians.

The poor performance of doctors in cardiopulmonary resuscitation has been described in several studies. The problem has been addressed in the last few years by simplifying treatment algorithms, establishing standards of competence, and creating a training framework. Resuscitation skills are also assessed during formal examinations such as those for the membership of the Royal College of Physicians (MRCP(UK)). In 1994 and 1996, we assessed the resuscitation skills of the candidates at our centre during the short-case section of the MRCP examination. With the correct preparation, there was no difficulty in carrying out detailed assessment of basic life support, defibrillation and advanced life support. This assessment was carried out separately from that of the examiners and did not interfere with the running of the short cases. The resuscitation skills of this small sample of an important group of doctors in training grades were unsatisfactory, and we suggest that more should be done to raise standards.

Cardiopulmonary Resuscitation↗