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Biomedical subjects

C Dadak

Publications and source records attributed to C Dadak.

At least 37 records · Page 2Linked to original sources
PubMed1988

[Organ-sparing surgery of leiomyomas of the uterus in young females].

At the IInd Dept. of Obstet. and Gynaecology, University of Vienna, in the five year period between 1979 and 1984 enucleation of uterine leiomyomas was performed in 27 cases. At the time of operation all of them desired children. All leiomyomas were located in the uterine corpus. The biggest one held 13 cm in diameter. In spite of avoiding endometrial lesions the cavity of the uterus was opened during surgery in 5 cases. None of the patients showed intra- or postoperative complications. We were able to receive follow-up informations of 21 patients. In 8 cases different contraceptives were used. 8 women became pregnant after surgery. Five of them had term deliveries, in three cases early abortions occurred. One woman suffered from recurrent leiomyomas, which led to hysterectomy 3 years later. These findings suggest that conservative surgery in cases of leiomyomas of the uterus could promote or preserve young women's fertility.

Adult↗
PubMed1987

[Type I diabetes mellitus and pregnancy: an interdisciplinary management program].

The obstetrical management of pregnant women with pregestational diabetes has been significantly improved throughout recent years. In the past, efforts to maintain euglycaemia during pregnancy in the presence of a labile maternal metabolism led to repeated, long-term hospitalization. In an interdisciplinary joint effort a protocol was delineated to obtain euglycemia throughout pregnancy by functional insulin therapy aiming at "near-normoglycemic insulin substitution (NIS)". In order to achieve this goal, home glucose monitoring and, depending on the glucose levels, self-made adjustments to the insulin therapy (according to individual algorithm) are the essential parts of this protocol. Of our study group of 18 pregnant diabetic women, already eight of them (2 class B, 1 class C, 1 class D, 2 class R and 2 class RF) have been delivered. The mean maternal age was 27 years (21-39). All metabolic variables of consequence for a diabetic woman were within the normal limits. The mothers' mean weight gain was 16 kg (12-20), and the mean gestational age at delivery was 37.8 weeks (35-40). The mean birth weight was 3293 grams (2700-3700) and all newborns were within the 50th percentile. Five fetuses were delivered by caesarian section (indications: proliferative retinopathy 3, breech presentation 1, previous caesarian section 1). No congenital malformations were found, nor macrosomia, respiratory distress syndrome or postpartum hyperglycaemia in the newborn. These preliminary results are encouraging. We feel that functional insulin therapy aiming at "near-normoglycaemic insulin substitution" promises to be very effective for women who are able and willing to follow the instructions received in the special education program.

Adult↗
PubMed1987

Prostaglandin metabolism in umbilical vessels of smoking and non-smoking mothers.

Arachidonic acid (AA) and its metabolites are responsible for the regulation of the umbilical blood flow. We investigated the prostaglandin (PG) synthesis in umbilical arteries and veins of 16 smoking and 17 non-smoking mothers. AA and PGs were analyzed after extraction of samples by means of thin layer chromatography (TLC). Of all the AA metabolites in umbilical arteries and veins, prostacyclin reached the highest concentration. In non-smoking mothers the conversion rate of AA in arteries and veins was similar. The only exception was PGE2 which showed a significantly lower concentration in umbilical veins of smoking mothers. However, the influence of PGE2 on the blood flow of umbilical arteries and veins seems to be of minor importance compared to other vessels.

Arachidonic Acid↗
PubMed1987

[Early second-look laparoscopy following surgical sterility interventions with the CO2 laser].

10 (48%) bilateral, 5 (24%) unilateral tubostomies, 1 (5%) unilateral and 1 (5%) bilateral fimbrioplastic were performed in 21 sterility patients. 21 female sterility patients underwent short-interval second-look-laparoscopy 8 days after reconstructive surgery (salpingostomy-10 bilateral/5 unilateral, fimbrioplasty-1 bilateral/1 unilateral, adhaesiolysis--16 bilateral/3 uni-lateral). The occurrence of postoperative adhesions was judged by the use of an adhesions-score. Compared to fertility surgery the initial median adhesion-score significantly decreased (p less than 0.0003--Wilcoxon Signed Ranks Test). A further reduction of the median adhesions-score could be achieved by short-interval-second-look-laparoscopy (p less than 0.0001). Within an observation time of 11 +/- 3.8 months one (5%) ectopic and 4 intrauterine pregnancies (19%) were found.

Adult↗
PubMed1986

[Relevance of palpatory, mammographic and thermographic assessment criteria in benign and malignant structural changes in the female breast].

The correlation between clinical findings, mammography and thermography on the one hand and histological structure of the breast on the other hand, was investigated in 133 women. Palpable changes in the breast parenchyma indicated excision biopsy in all cases. The following criteria were employed for palpatory assessment: size, differentiation, nodular mobility and consistency. For mammography, criteria such as calcification, opacity, contralateral comparison and skin thickening were used. For thermography, a modified "Gautherie score" was employed. All three palpatory parameters, however, do not provide reliable differentiation between benign and malignant tumours, since the palpatory findings in fibrocystic disease are similar to those in large malignant growths. Small malignant growths, in turn, may resemble benign tumours. Furthermore, the group of fibrocystic disease markedly reduces the specificity of the radiological findings. However, as aid to differential diagnosis it may be said that apart from the shape of the shadow, contralateral difference in appearance is more likely to occur with benign and malignant tumours than with fibrocystic disease. With regard to thermography a low score i.e. an unconspicuous picture of heat distribution is unlikely to signify a malignant growth. It is, however, impossible to distinguish between mastopathy and malignant tumour. Additional investigations i.e. mammography and thermography do not rule out the existence of a malignant growth.

Biopsy↗
PubMed1986

[HELLP syndrome: a rare, threatening complication in pre-eclampsia].

A very rare, but severe complication, occurring together with preeclampsia, is the so-called HELLP syndrome (H for haemolysis, EL for elevated liver enzymes and LP for low platelet counts). Perinatal mortality for this syndrome is estimated at 9.5% up to 60%, maternal mortality at 3.5%. We examined retrospectively 11 patients of the last 5 years, presenting not only hypertension, proteinuria and oedema, but also pathologically elevated data concerning transaminases, indirect bilirubin and thrombocytopenia; the mean value for GI in this group was 7.7 (3-11). Thrombocyte counts showed mean values of 71,000 +/- 28,500. In 9 cases the patients suffered from severe upper abdominal pain. Liver enzymes and bilirubin were clearly elevated. Time interval between onset of therapy and delivery was 3 days on the average, the mean gestational age at time of delivery was 34 weeks (27-39), average infant weight amounted to 1,960 g (580-3,700 g). 7 of the 11 women delivered by Caesarian section (64%); perinatal, respectively neonatal 3 babies died (27%). In two cases one Caesarian section did not produce maternal complications; 3 women had to undergo a hysterectomy. This syndrome is associated with a very problematic obstetrical situation in respect of differential diagnosis, foetal outcome and the high frequency of postoperative maternal complications.

Adult↗
PubMed1985

[The course of pregnancy and fetal outcome after cesarean section].

The management of pregnant women with a history of one or more previous caesarean sections has gained enormous importance in view of the increased frequency of delivery by this operative procedure over the past decade. The risks of pregnancy and delivery in this particular group of women have been investigated in this statistical study of 316 women, whereby special attention has been paid to the mode of delivery and fetal outcome in comparison with a matched-pair group of the same parity. Repeat caesarean section was required in 58.9% of the test group and vacuum extraction or forceps delivery was necessary in 7.9% of cases, the incidence of these operative procedures being far higher than in the control group. However, the fetal outcome was very similar in both groups, with an uncorrected perinatal mortality of 2.5% and 1.9% in the test and control groups, respectively. The 1' and 5' Apgar scores were worse in those newborn infants delivered by vaginal operation or emergency caesarian section. The vaginal delivery of women with a history of caesarean section is not only perfectly feasible, but is connected with little risk provided mother and fetus are monitored with utmost care.

Adult↗
PubMed1985

[Fertility following function-preserving surgery in tubal pregnancy].

In the last few years an obvious trend toward conservative technique in tubal surgery is observed. Likewise, at our institution, emphasis was placed on preservation of function, too. 59 patients received conservative surgery of tubal pregnancies between 1979 to 1982. 7 women were lost for follow-up. 28 patients showed further desire for child-bearing. 20 of them have had a subsequent intrauterine conception (71.4%), 11 women have had term pregnancies (39.3%). 3 patients were pregnant at time of investigation. The abortion rate was 17.8%. Recurrent ectopic pregnancies were found in 5 cases (9.5%). However, the operated fallopian tube was involved only in 3 cases (5.7%). In 26 cases the patency of the tubal lumen was examined by means of hysterosalpingography. 50% of those women had remained childless. The results of HSG showed a patent passage of the operated tube in 11 cases. Our results show a high rate of subsequent pregnancies and a rather low incidence of repeat ectopic pregnancies in cases of conservative surgery and justify our decision to save the involved tube whenever fertility is desired.

Abortion, Spontaneous↗
PubMed1985

Prostacyclin-synthesis stimulating plasma factor and platelet sensitivity in preeclampsia.

Hemostatic regulation is partly maintained by antiaggregatory and vasodilative prostaglandins (PGI2, PGE1, PGD2) and by the proaggregatory and vasoconstrictive Thromboxane A2. PGI2-Synthesis is regulated by a plasma factor (PF). This plasma factor and the platelet sensitivity (PS) to PGI2 and PGE1 decrease during pregnancy towards term. In preeclampsia PF and PS is more decreased than in healthy pregnant women. Both parameters increase significantly after delivery. The decreased values of PF and PS in preeclampsia demonstrate a dysregulation of hemostasis in preeclampsia.

Epoprostenol↗
PubMed1984

Prostacyclin synthesis stimulating plasma factor in pregnancy and puerperium.

Prostacyclin is assumed to play a key role in maintaining a sufficient blood flow in maternal and fetal circulation. Recent reports pointed out that the prostacyclin synthesis is regulated by a so-called plasma factor. The activity of this plasma factor was tested during pregnancy, labor, and puerperium. During the first and second trimesters, increased values could be observed, whereas in the third trimester and at the onset of labor, the values decreased. After delivery, there was again a moderate increase in plasma factor activity. A feedback mechanism is discussed between prostacyclin or 6-oxo-prostaglandin F1 alpha and the plasma factor, but hormones, such as 17 beta-estradiol, may possibly influence prostacyclin synthesis in pregnancy.

Animals↗
PubMed1984

[Hydrops universalis and respiratory distress due to congenital lung tumor].

A case of an immature female newborn child is reported, with a solitary alveolarcell adenoma rising from the left lower lobe of the lung. The consequences of the congenital blastoma of the lung, which is to be regarded as hamartoma, are Hydrops fetalis, a polyhydramnion, respectively a Respiratory Distress not responding to treatment. Finally a survey of the available literature is given on non-immunologic Hydrops fetalis caused by congenital tumors.

Adenoma↗
PubMed1983

[Prostacyclin therapy in EPH gestosis (preliminary report)].

EPH-gestosis is still today one of the most dangerous complications of pregnancy, threatening both, maternal and fetal life. Until now only symptomatic treatment was possible. A new mode of treatment of EPH-gestosis may evolve from the use of prostacyclin, a potent vasodilator and inhibitor of platelet aggregation. We tried prostacyclin therapy in three patients with severe gestosis. The results of prostacyclin infusion on this condition, the pregnancy, the fetus, the placenta and the morphology of the umbilical artery are discussed.

Adult↗