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C D Simpson

Publications and source records attributed to C D Simpson.

14 recordsLinked to original sources
PubMed2001

Use of visual evoked-potential studies and EEG data to classify aggressive, explosive behavior of youths.

OBJECTIVE: Data from electroencephalograms (EEGs), including data from visual evoked-potential studies, were analyzed to assess their association with a specific type of explosive behavior in children and adolescents. METHODS: Data for 326 children and adolescents treated in a psychiatric clinic were examined. Eighty-two percent exhibited behavior consistent with intermittent explosive disorder, although diagnosis was not an inclusion criterion for the study. The presence of explosive behaviors was indicated by reports from the legal system, schools, parents, health care workers, and psychiatric intake interviews. A quantitative EEG and a series of pattern-reversal evoked-potential studies were administered to each patient. In these studies, children are shown a rapidly reversing checkerboard pattern or rapid flashes of light, and their brain waves (evoked potentials) are measured. RESULTS: Logistic regression indicated that patients who exhibited explosive behaviors were significantly more likely to produce high-amplitude P100 wave forms in the evoked-potential studies than patients who did not exhibit explosive behaviors. Forty-six percent of those with explosive behaviors met the clinically defined electrophysiological criteria for the high-amplitude P100 wave forms. CONCLUSIONS: The use of visual evoked-potential studies helped us classify a large subset of youths who exhibited out-of-control explosive behaviors. The findings suggest that a subgroup of individuals exhibiting explosive behaviors may have a predisposition for violent or explosive behavior that is an innate characteristic of their central nervous system. An understanding of the etiology of explosive behaviors permits the use of more appropriate intervention and treatment strategies.

Adolescent↗
PubMed2000

Determination of r-7,t-8,9,c-10-tetrahydroxy-7,8,9, 10-tetrahydrobenzo[a]pyrene in human urine by gas chromatography/negative ion chemical ionization/mass spectrometry.

r-7,t-8,9,c-10-Tetrahydroxy-7,8,9,10-tetrahydrobenzo[a]pyrene (trans-anti-BaP-tetraol) is the major hydrolysis product of r-7, t-8-dihydroxy-t-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (anti-BPDE), the principal ultimate carcinogen of the environmental pollutant benzo[a]pyrene (BaP). As part of a program to establish activation/detoxification profiles of urinary metabolites of BaP in humans, we developed a method for quantifying trans-anti-BaP-tetraol. Urine was collected from three groups of individuals exposed to BaP: psoriasis patients treated with a coal tar-containing ointment, steel workers, and smokers. [(2)H(12)]-trans-anti-BaP-tetraol was added to the urine as an internal standard. The urine was treated with beta-glucuronidase and sulfatase, and then the BaP-tetraols were enriched by reverse-phase and phenylboronic acid solid-phase extraction. The resulting fraction was treated with sodium hydride and methylmethane sulfonate to convert BaP-tetraols to the corresponding tetramethyl ethers (BaP-TME). The mixture was purified by normal-phase HPLC and analyzed by gas chromatography/negative ion chemical ionization/mass spectrometry with selected ion monitoring. [(13)CH(3)](4)-trans-anti-BaP-TME was used as an external standard. Ions at m/z 376, 380, and 388 were monitored for quantitation of trans-anti-BaP-TME, [(13)CH(3)](4)-trans-anti-BaP-TME, and [(2)H(12)]-trans-anti-BaP-TME, respectively. The instrumental detection limit was approximately 1 fmol of trans-anti-BaP-TME. trans-anti-BaP-tetraol (as trans-anti-BaP-TME) was detected in 20 of 20 individuals receiving coal tar therapy (mean, 16 fmol/mL of urine), 13 of 13 exposed steel workers (mean, 4.1 fmol/mL of urine), and nine of 21 cigarette smokers (mean, 0.5 fmol/mL of urine). The means in these groups were significantly different (P < 0.0001). The urine of steel workers was also analyzed for cis-anti-BaP-tetraol and cys-syn-BaP-tetraol, but neither was found. The results of this study provide a quantitative method for determination of parts per trillion levels of trans-anti-BaP-tetraol in human urine. Ultimately, this method can be employed as part of a phenotyping approach for assessing BaP metabolites in human urine.

7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide↗
PubMed1998

Characterization of a type-common human recombinant monoclonal antibody to herpes simplex virus with high therapeutic potential.

We report the characterization of a type-common human recombinant monoclonal antibody previously isolated by antigen selection from a phage-displayed combinatorial antibody library established from a herpes simplex virus (HSV)-seropositive individual. Competition with well-characterized murine monoclonal antibodies and immunodetection of gD truncations revealed that this antibody recognizes the group Ib antigenic site of glycoprotein D, a highly conserved and protective type-common determinant. To our knowledge, this is the first human group Ib monoclonal antibody ever described. The antibody also displayed first-order neutralization kinetics and a high neutralization rate constant, was capable of completely inhibiting syncytium formation by a fusogenic strain of HSV type 1, and efficiently neutralized low-passage clinical isolates of both HSV serotypes. Taken together with our earlier observations of the in vivo antiviral activities of this human recombinant antibody in animal models of HSV infection, the present results support the high therapeutic potential of this antibody.

Animals↗
PubMed1997

Azathioprine-induced pericarditis in a patient with ulcerative colitis.

Inflammatory bowel disease is rarely associated with pericarditis but both sulfasalazine and the aminosalicylates have been known to cause this complication. To the author's knowledge this is the first reported case of acute pericarditis caused by azathioprine. It is believed that pericarditis is yet another potential manifestation of hypersensitivity to this drug.

Adult↗
PubMed1996

Composition and distribution of polycyclic aromatic hydrocarbon contamination in surficial marine sediments from Kitimat Harbor, Canada.

Surficial marine sediments from 20 sites within the Kitimat fjord system were analyzed for polycylic aromatic hydrocarbons (PAHs). Levels of the sum of the 16 USEPA priority pollutant PAHs varied from below detection limits (ca. 1 microg x g-1) to over 10 000 microg x g-1. Sediment PAH levels were highest in the immediate vicinity of a large aluminum smelter at the head of Kitimat Arm, and declined rapidly with increasing distance from the smelter. However, even at some of the more distant sites which are geographically isolated from the smelter PAH levels were elevated. The PAH distribution in the fjord system is consistent with a combination of aeolian and fluvial transport of PAHs emitted by the aluminum smelter at the head of Kitimat Arm. The mixture of PAHs present was qualitatively similar in all samples analyzed, including those from the distant sites. All aspects of the PAH composition are consistent with combustion generated PAHs. A correlation between PAH levels and sediment organic carbon was observed; however, this was only significant for highly contaminated sites in the harbor. This probably reflects the high organic content of particulate emissions from the smelter, rather than equilibrium partitioning of PAHs to sediment organic carbon within the harbor itself.

Aluminum↗
PubMed1982

Consumer acceptability of ground venison.

The acceptability of ground venison was evaluated by 91 consumers. Four meat patties were formulated: 100 percent beef, 100 venison, 50 percent venison/50 percent beef, and 50 percent venison/50 percent pork. The four patties received similar acceptability scores, except that the all-venison patty was less juicy and had a stronger game flavor. Mixing venison with beef or pork in a patty with about 18 percent fat increased the juiciness and decreased the game flavor. Mixing ground venison with ground beef or pork could make venison more palatable to consumers.

Animals↗
PubMed1979

Serological studies on sympatric Barbary sheep and mule deer from Palo Duro Canyon, Texas.

Sera were collected from 12 Barbary sheet (Ammotragus lervia) and 11 mule deer (Odocoileus hemionus) occupying sympatric ranges in Palo Duro Canyon, Texas. These were tested for leptospirosis, brucellosis, bovine virus diarrhea, anaplasmosis, vesicular stomatitis, bluetongue (BT), epizootic hemorrhagic disease (EHD), infectious bovine rhinotracheitis (IBR), and coccidioidomycosis. Serologic reactors were found to IBR in 3 Barbery sheep, BT in 6 Barbary sheep and 6 mule deer and EHD in 3 Barbary sheep and 4 mule deer. Possible ramifications of evidence for these diseases in wild herbivore populations in this area are discussed.

Anaplasmosis↗