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Biomedical subjects

C D Shee

Publications and source records attributed to C D Shee.

27 records · Page 2Linked to original sources
PubMed1985

Decay of inspiratory muscle pressure during expiration in conscious humans.

In eight conscious spontaneously breathing adults we studied the decay of pressure developed by the inspiratory muscles during expiration (PmusI). PmusI was obtained according to the following equation: PmusI(t) = Ers X V(t) - Rrs X V(t), where V is volume and V is flow at any instant t during spontaneous expiration, and Ers and Rrs are, respectively, the passive elastance and resistance of the total respiratory system. Ers was determined with the relaxation method, and resistance with the interrupter method. All subjects showed marked braking of expiratory flow by PmusI. The mean time for PmusI to reduce to 50 and 0% amounted, respectively, to 23 and 79% of expiratory time. During expiration, 24-55% of the elastic energy stored during inspiration was used as resistive work and the remainder (45-76%) as negative work.

Adult↗
PubMed1984

Self-administered home intravenous antibiotic therapy in bronchiectasis and adult cystic fibrosis.

10 patients (mean age 23.1, range 17.1-40.5 years), 8 with cystic fibrosis (CF), and 2 with advanced bronchiectasis without CF, were taught, while being treated in hospital for exacerbations of pseudomonas infection, how to continue to give themselves intravenous antibiotics at home. They were discharged after satisfactory antibiotic levels had been achieved, and 22 courses were given at home over a total of 116 patient-days. In 14 of these, the greater part of the course was given at home (mean duration 6.6, range 5-10 days); 2 of these were given without admission to hospital. In the 8 patients with two or more infective exacerbations within a 12-month period there was no difference between home and hospital treatments in clinical improvement or in relapse time, defined as the interval between completion of treatment and subsequent antibiotic therapy. Self-administration of antibiotics intravenously at home for selected adults with cystic fibrosis and severe bronchiectasis reduces hospital stay and does not seem to be associated with an increased rate of recurrent infection.

Adolescent↗
PubMed1984

Treatment of asthma in a general practice.

We examined the general practice treatment of 67 patients diagnosed as asthmatic. Compliance with treatment was poor in one-third of patients with severe asthma. Inhaled steroids were under-prescribed and our findings suggest that some severe asthmatics are receiving less than adequate therapy.

Adolescent↗
PubMed1979

Stopping phenformin treatment in a diabetic clinic.

Phenformin was stopped in 35 patients attending a diabetic clinic. In 4 patients where phenformin alone had been used, subsequent diabetic control was easily maintained with diet or a sulphonylurea. Thirty-one patients had been taking phenformin with a sulphonylurea and 17 (55%) later required insulin. Larger doses of a sulphonylurea were usually needed in the other patients. It is suggested that metformin is probably the biguanide of choice now and should be considered in carefully selected diabetics.

Acidosis↗