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Biomedical subjects

C D Scopa

Publications and source records attributed to C D Scopa.

26 records · Page 2Linked to original sources
PubMed1991

Diagnosis of thyroid cancer in southwestern Greece.

A prospective study of 1,200 patients with thyroid disease was performed from 1983 to 1988 to appraise the reliability of various diagnostic techniques in patients with thyroid cancer. Histologic confirmation was obtained in 201 patients. By assuming that only solid lesions, single or multiple, represented malignancy, the sensitivity and specificity of ultrasonography was 4.64 and 52.2%, respectively. Findings of fine needle aspiration (FNA) cytology and of carcinoembryonic antigen (CEA) serum concentration were also evaluated. The sensitivity and specificity of these two methods (91.2% and 84.1% for FNA and 89.7% and 81.3% for CEA, respectively) were found to be high enough to permit surgical intervention after a diagnosis of malignancy was made. It appears that the combination of FNA cytology and CEA serum measurement represents the most accurate method for the pre-operative detection of thyroid cancer.

Biopsy, Needle↗
PubMed1991

Radical consequence in the sexuality of male patients operated for colorectal carcinoma.

Sixty sexually-active male patients affected by colorectal cancer and surgically treated at the Department of Surgery at University of Patras between 1981 and 1987 were interviewed by structured questionnaire to evaluate the etiology of sexual dysfunction. Patients were divided into three groups: (1) 20 patients, mean age 60.5 years (range 39-70), subjected to high anterior resection for carcinoma of the sigmoid colon (not lower than 18 cm from the anal margins, 1.2% Dukes' A, 31% Dukes' B, 67.8% Dukes' C); (2) 20 patients, mean age 62.4 years (range 43-70), subjected to low anterior resection (not more than 8 cm from the anal margins, 3% Dukes' A, 36% Dukes' B, 61% Dukes' C); and (3) 20 patients, mean age 59.75 years (range 27-70), subjected to abdominoperineal surgery (Miles' technique) in whom the malignancy was in the distal rectum (8% Dukes' A, 32% Dukes' B, 60% Dukes' C). The first group served as the control. All the anastomoses in the low anterior resection group were performed by manual suture. Statistical evaluation of the three groups was by the chi 2-test. The form of sexual dysfunction, (1) cessation of sexual relationship, (2) absence of erection, (3) impossible penetration or (4) absence of ejaculation, varied according to the type of operation, the frequency of each form being 5%, 5%, 30%, 20% for the high anterior resection, 65%, 45%, 60%, 50% for Miles' operation and 20%, 25%, 45%, 5% for the low anterior resection respectively.

Adult↗
PubMed1990

Tissue imprints in surgical pathology: a rapid intraoperative diagnostic aid.

We studied the intraoperative diagnostic value of imprint cytology in 230 samples obtained from surgical specimens submitted for frozen section diagnosis. A rapid hematoxylin-eosin stain was used. Intraoperative imprint cytology achieved an accuracy rate of 94.3%; for benign lesions the accuracy was 97.5%, and for malignant lesions it was 91%. Overall, the false-negative and suspicious-for-malignancy rates were 1.3% and 4.3%, respectively. No false-positive results were found. The diagnostic yield when intraoperative imprint cytology and frozen section were used together was 99%. It is apparent that imprint cytology is a quick and simple method with wide applicability in the histopathologic diagnosis of lesions from all organs. The value of the method is enhanced when it is used with frozen section diagnosis.

Breast Neoplasms↗
PubMedDate not supplied

Fibrin glue for sealing the needle track after percutaneous lung biopsy: Part I--Experimental study.

PURPOSE: Evaluate the effectiveness of fibrin glue for the embolic occlusion of needle tracks following percutaneous lung biopsy (PLB). METHODS: Twenty-six rabbits underwent computed tomography (CT)-guided PLB using a coaxial system consisting of 19- and 22-gauge needles. Thirteen rabbits were used as controls (group A). In 13 other rabbits (group B), fibrin glue labelled with I131 fibrinogen and contrast medium was injected into the track. Both groups were examined by CT for the presence and severity of pneumothorax (mild: less than 20%; severe: more than 20%). Group B was also examined scintigraphically and their lungs were studied histologically. RESULTS: In group A, pneumothorax developed in eight animals (61.6%) and was severe in six (46.1%) whereas in group B, pneumothorax developed in five animals (38.5%) and was severe in one (7.7%). Though the difference between the two groups in overall incidence of pneumothorax was not significant (p > 0.1), it was significantly higher (p < 0.025) for severe pneumothorax in group A. No signs of systemic embolism were observed. CONCLUSIONS: Based on this animal model, fibrin glue is a safe and useful sealant following PLB and reduces the incidence of severe pneumothorax.

Animals↗
PubMedDate not supplied

Microvessel density, proliferating activity, p53 and bcl-2 expression in in situ ductal carcinoma of the breast.

BACKGROUND: Ductal carcinoma in situ (DCIS) of the breast represents a heterogeneous group of lesions that show important differences in biologic behavior. New vessel formation has been reported as a prognostic indicator in breast carcinoma, but little information is available about its significance in DCIS. This study was planned to examine angiogenesis in DCIS in relation to histologic subtype, proliferation activity, p53 and bcl-2 expression. MATERIALS AND METHODS: Paraffin sections from 24 cases of DCIS (9 comedo and 15 non comedo type) were studied immunohistochemically using polyclonal and monoclonal antibodies to von Willebrand factor, Ki-67, p53 (clone 1801) and bcl-2 proteins. The streptavidine-biotin technique with microwave antigen retrieval was employed. RESULTS: Most cases showed enhanced microvessel formation around ducts with DCIS compared to normal ducts. Comedo carcinomas (CCs) showed enhanced neovascularization compared to non comedo carcinomas (NCCs). Growth fraction determination with Ki-67 antibody showed that 78% of the CCs expressed high proliferating activity compared to 27% of the NCCs. p53 immunoexpression was noted in 78% of the CCs and 20% of the NCCs. Bcl-2 immunoreactivity was observed in 67% of the total cases in 58% of which there was no association with p53 expression. However, an association was found between neovascularization and overexpression of Ki-67 and p53. CONCLUSIONS: This study suggests that neovascularization is an early phenomenon in breast neoplasia and is apparent as early as the in situ stage. CCs express a more aggressive immunophenotype, compared to the other DCIS subtypes, characterized by increased stromal interaction, high proliferating activity, p53 overexpression and a near lack of bcl-2 immunostaining.

Adult↗
PubMedDate not supplied

Frozen section diagnosis: a quality control study.

In a quality control study we reviewed six hundred and eighty one frozen section specimens sent to our department from 1981 to 1989. Accuracy was 98%. Diagnosis was deferred in 1%. False positive diagnosis for malignancy was made in one (0.15%) case and false negative diagnosis for malignancy in thirteen (2%) cases. Most of the inaccurate diagnoses concerned the female breast and the omentum. Incorrect diagnoses were due to interpretation of the pathologic findings (50%), to microscopic sampling (36%) and to gross sampling (14%). Some of the lesions are difficult to diagnose even in permanent sections. Technical skill and diagnostic expertise are essential for high diagnostic accuracy in the method of frozen section.

False Negative Reactions↗
PubMedDate not supplied

Nuclear grooves in fine needle aspiration (FNA) biopsies of breast lesions.

The present study was undertaken to evaluate the significance of grooved nuclei as an additional diagnostic criterion for primary breast carcinoma as well as their association with tumor grade in cytologic material obtained by fine needle aspiration (FNA). Cytologic slides of 105 cases of breast carcinoma (89 ductal, 10 lobular, 3 medullary, 3 mucinous) and 39 cases of benign lesions were reviewed. Histologic confirmation was obtained in all cases. In each case the number of grooved nuclei per 200 well-preserved cells per slide was recorded. Nuclear grooves were found in 62% (65/105) of the malignant and in 36% (14/39) of the benign lesions. This cytomorphologic feature was observed in all histologic types of breast carcinoma. Furthermore, nuclear grooves were present in all grades of ductal carcinoma, and at about the same frequency. Our findings indicate that in the mammary gland nuclear grooving cannot be considered as a criterion of malignancy, and is not helpful either in differentiating the various histologic types or in grading breast tumors in FNA preparations.

Adolescent↗