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Biomedical subjects

C D Pengelly

Publications and source records attributed to C D Pengelly.

4 recordsLinked to original sources
PubMed1979

A prospective randomized trial of vagotomy in chronic duodenal ulceration.

In a prospective, randomized trial, 76 patients with duodenal ulceration treated by truncal vagotomy and pyloroplasty were compared with 77 patients who underwent highly selective vagotomy. A total of 149 patients was followed up for from 1 to 4 years, the average follow-up period being 2.6 years. There was no operative mortality and no significant difference in postoperative morbidity between the two groups. The incidence of recurrent ulceration was greater after highly selective vagotomy, but this difference was not statistically significant. The clinical results were comparable in each group, and although the incidence of diarrhoea and dumping was greater after vagotomy and pyloroplasty, this difference was not statistically significant.

Adult↗
PubMed1975

Remission of active chronic hepatitis after treatment with cyclophosphamide and prednisolone. Report of four cases.

A description is given of four patients with active chronic hepatitis, all of whom were treated with prednisolone and cyclophosphamide. In all the patients diagnosis was established by the finding of a clinical picture of hepatic dysfunction associated with abnormal results of biochemical tests of liver function, evidence of disturbed immunity mechanisms and liver biopsy. After treatment all four patients made a clinical recovery. Three eventually had normal serum tests for liver function, normal bromsulphthalein excretion tests and normal histology in their needle liver biopsies. The fourth patient has shown considerable improvement in her serum tests of liver function, but she has been treated for a much shorter period than the others. Her test results are still improving. It is concluded that the combination of prednisolone and cyclophosphamide therapy is a satisfactory one for active chronic hepatitis, and probably superior to other therapeutic measures based upon the suppression of autoimmune mechanisms.

Adult↗