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Biomedical subjects

C D Mills

Publications and source records attributed to C D Mills.

44 records · Page 3Linked to original sources
PubMed1981

Blood oxygen content in microliter samples using an easy-to-build galvanic oxygen cell.

We have designed a simple, inexpensive, easy-to-build and operate apparatus for measuring blood oxygen content. The galvanic oxygen cell (fuel cell) requires as little as 1 microliter of blood and has a measuring time of 1-3 min. It is well suited for measuring oxygen content in fluids low in oxygen inasmuch as the sensitivity of the instrument is variable. Either air or water (at a known temperature and oxygen tension) can be used for calibration. No significant differences in blood oxygen content measured with our cell or the Van Slyke manometric method were found.

Blood Gas Analysis↗
PubMed1977

Effect of arterial carbon dioxide on cerebral blood flow in ducks.

The purpose of this study was to determine the effect of arterial PCO2 on blood flow to the avian brain. Cerebral blood flow was measured on curarized, artificially ventilated Pekin ducks by the rate at which intra-arterially injected xenon-133 was cleared from the duck's brain. A two-component clearance curve resulted: the blood flow calculated from the fast and slow components was similar to the blood flow to mammalian grey and white matter, respectively. Hypercapnia markedly increased the fast component of blood flow, whereas hypocapnia had no effect on this component. These effects were not due to changes in blood pressure, which was independent of arterial PCO2. Blood flow calculated from the slow component was independent of arterial PCO2. We conclude that the lack of response to hypocapnia may contribute to the exceptional tolerance of birds to high altitude by maintaining normal cerebral blood flow.

Animals↗
PubMed1976

Heat loss from feet of herring gulls at rest and during flight.

The role of the feet of herring gulls (Larus argentatus) in heat dissipation was estimated during rest and wind-tunnel flight. We determined the blood flow to the feet and the arteriovenous temperature difference and thus estimated heat loss from the feet. Determinations of oxygen consumption and respiratory water loss at rest gave a heat production of about 8 W; 37-56% of this heat was lost from the feet (air temp = 10-35 degrees C). During flight heat production was estimated to be about 57 W and heat loss from the feet was 46 W, about 80% of the heat production in flight. Thus the webbed feet are an important avenue of heat loss in the herring gull.

Animals↗
PubMedDate not supplied

Comparison of the ParaSight-F test and the ICT Malaria Pf test with the polymerase chain reaction for the diagnosis of Plasmodium falciparum malaria in travellers.

Rapid and accurate methods are needed for the diagnosis of imported malaria. The ParaSight-F test and the ICT Malaria Pf test are commercially available kits marketed for the diagnosis of Plasmodium falciparum malaria. Both tests are antigen-capture assays based on the detection of P. falciparum histidine-rich protein 2 in peripheral blood. Using microscopy and a polymerase chain reaction (PCR)-based method as reference standards, we performed a 'blinded' comparison of these assays for the detection of P. falciparum infection in 200 febrile travellers returning from malaria-endemic areas. As determined by PCR and microscopy, 148 travellers had malaria and, of these patients, 54.7% (81/148) were infected with P. vivax only, 31.1% (46/148) with P. falciparum only, 9.5% (14/148) with P. ovale, 0.7% (1/148) with P. malariae, and 4.1% (6/148) had mixed infections. Compared to PCR, the ParaSight-F and ICT Malaria Pf tests had initial sensitivities of 94% and 90% and specificities of 95% and 97%, respectively, for the detection of P. falciparum malaria. When discrepant samples were retested with day 0 and day 1 bloods, the sensitivities improved to 96% and 94%, respectively. The 2 remaining false negative results with the Para-Sight-F test and 2 of the 3 false negative results with the ICT Malaria Pf test occurred in samples with < 100 parasites/microL. The performance of these kits was not significantly different (P = 0.75) and both are simple, rapid, and accurate tests for the detection of P. falciparum infection in the returned traveller.

Adolescent↗