Relevance of cellular autonomy to regulatory decisions.
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Biomedical subjects
Publications and source records attributed to C D King.
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In a survey of 546 rhesus monkeys of various ages, 6.1% of the animals showed ophthalmoscopically visible hypopigmented spots in their maculas. There was a statistically significant correlation between the age of the animal and the degree of hypopigmentation. Electroretinographic responses and visually evoked potentials were evaluated in a selected group of monkeys with and without hypopigmented macular spots. No significant change in retinal function as a result of the macular abnormalities could be detected.
The effects of isoproterenol, theophylline and the combination of the two drugs were studied on the circadian mitotic rhythm in rat corneal epithelium. The drugs induced profound alterations in the normal circadian mitotic pattern. The alterations included an initial suppression of cell division, followed by two distinct rises above control; the first immediately following suppression, the second 12-16 hr following drug administration. The second peak of cell division occurred at the circadian trough in controls. The simultaneous administration of isoproterenol and theophylline greatly magnified the effects seen with either drug alone.
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