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Biomedical subjects

C D Johnson

Publications and source records attributed to C D Johnson.

At least 361 records · Page 20Linked to original sources
PubMed1981

Cross-linking and binding of fibronectin with asymmetric acetylcholinesterase.

The similarities between the tail of asymmetric acetylcholinesterase (AcChE) and collagen prompted us to investigate if asymmetric AcChE, like collagen, can interact with fibronectin. Gradient centrifugation studies revealed that asymmetric, but not globular, AcChE bound to fibronectin and could be cross-linked covalently to fibronectin by plasma transglutaminase. The interaction of asymmetric AcChE with fibronectin paralleled the interaction of fibronectin with collagen. These results raise the possibility that fibronectin may be involved in attaching asymmetric AcChE to cell surfaces.

Acetylcholinesterase↗
PubMed1981

An acetylcholinesterase-deficient mutant of the nematode Caenorhabditis elegans.

Within a set of five separable molecular forms of acetylcholinesterase found in the nematode Caenorhabditis elegans, previously reported differences in kinetic properties identify two classes, A and B, likely to be under separate genetic control. Using differences between these classes in sensitivity to inactivation by sodium deoxycholate, a screening procedure was devised to search for mutants affected only in class A forms. Among 171 previously isolated behavioral and morphological mutant strains examined by this procedure, one (PR946) proved to be of the expected type, exhibiting a selective deficiency of class A acetylcholinesterase forms. Although originally isolated because of its uncoordinated behavior, this strain was subsequently shown to harbor mutations in two genes; one in the previously identified gene unc-3, accounting for its behavior, and one in a newly identified gene, ace-1, accounting for its selective acetylcholinesterase deficiency. Derivatives homozygous only for the ace-1 mutation also lacked class A acetylcholinesterase forms, but were behaviorally and developmentally indistinguishable from wild type. The gene ace-1 has been mapped near the right end of the X chromosome. Gene dosage experiments suggest that it may be a structural gene for a component of class A acetylcholinesterase forms.

Acetylcholinesterase↗
PubMed1980

A hazardous materials identification system for the coating and resins industry.

Several thousand raw materials ranging from naturally occurring minerals to highly toxic biocidal agents are employed in the manufacture of coatings and resins. The batch-type operations of this industry require employees to handle many different materials each day, so an easily recognizable and effective hazardous materials warning system is requisite. Such a system has been developed in the Coatings and Resins Division of PPG Industries and is called the "Safety and Health Index System". With this system, it is now possible for PPG employees to know the potential health, flammability and reactivity hazards associated with each bag or drum they may handle and take the necessary precautions to protect themselves.

Humans↗