Search PubMed⌕ Search

Biomedical subjects

C D Friedman

Publications and source records attributed to C D Friedman.

48 records · Page 3Linked to original sources
PubMed1989

Neurofibromatosis type II of the head and neck.

Neurofibromatosis type II (NF-II) has been traditionally referred to as "acoustic" neurofibromatosis and is not known to be genetically distinct from classic von Recklinghausen's disease (NF-I). Neurofibromatosis type II is due to a lesion on chromosome 22q, while von Recklinghausen's neurofibromatosis is from a defect on chromosome 17. The approximate incidence of NF-II is one in 50,000, with bilateral acoustic neuromas occurring in over 90% of those with the abnormal gene. We studied a 17-year-old boy with NF-II who presented with bilateral acoustic neuromas and concomitant primary nasopharyngeal meningioma. Less than 30 nasopharyngeal meningiomas have been documented, and the presence of both tumor types in the same individual is unique in the literature.

Adolescent↗
PubMedDate not supplied

Reconstruction of the frontal sinus and frontofacial skeleton with hydroxyapatite cement.

OBJECTIVE: To evaluate the efficacy of a newly developed biomaterial, hydroxyapatite cement, for use in frontal sinus and anterior craniofacial skeletal reconstruction. DESIGN: A nonrandomized patient cohort that was compared with historical controls of standard treatment with methyl methacrylate implants. SETTING: Craniofacial reconstructive surgery services at 3 referral health care centers. Eligible patients had frontal-cranial defects limited to a maximum size of 25 cm2. Patients were randomly selected volunteers with preexistent, acute traumatic or acute surgically induced defects of the frontal sinus and anterior craniofacial skeleton. All patients provided informed consent, and the study was approved by the 3 institutional review boards. Forty patients underwent reconstruction of defects of the anterior craniofacial region, and 38 of these patients were evaluable at 24 months. MAIN OUTCOME MEASURES: Hydroxyapatite cement was used to reconstruct full-thickness anterior craniofacial skull defects. Standard surgical techniques were used to place all implants. The primary outcome measurement was maintenance of implant volume determined at 24 months by computed tomography and clinical examination. Secondary outcome measures included incidence of complications and infections necessitating implant removal. RESULTS: Of the 38 evaluable patients, 31 had successful reconstructions at the end of the study, for an overall success of 82% for frontal sinus and frontofacial region reconstruction. Seven patients underwent explantation, 5 for surgical access to the site. Two implants were removed because of infection in the wound, for an overall incidence of approximately 5%. Explant biopsy specimens confirmed implant osseointegration and vascularization. CONCLUSIONS: Hydroxyapatite cement successfully reconstructs full-thickness defects of the frontal sinus and frontofacial region at 24 months. Hydroxyapatite cement appears to be superior to acrylic implants for frontal-cranial reconstruction and by allowing implant osseointegration with improved biocompatibility.

Adult↗
PubMedDate not supplied

Future directions in biomaterial implants and tissue engineering.

Over the last 50 years, we have gained much knowledge about biomaterial implants by incorporating the fields of basic biologic science and engineering science. Future implant developments will have a significant impact on facial cosmetic and reconstructive surgical therapy.

Biocompatible Materials↗
PubMedDate not supplied

Renal cell carcinoma with metastasis to the parotid gland: case reports and review of the literature.

Two cases of renal cell carcinoma metastatic to the parotid gland are presented. The parotid mass was the initial manifestation of the first patient's renal cell malignancy and the pathologic evaluation was the first clue to the diagnosis. The second case demonstrates discovery of metastasis to the parotid gland 8 years after resection of a hypernephroma. A review of the literature on this subject is presented and the pathologic characteristics as well as recommendations for diagnosis and treatment of this entity are reviewed.

Aged↗
PubMedDate not supplied

DentaScan imaging of the mandible and maxilla.

DentaScan is a unique new computer software program which provides computed tomographic (CT) imaging of the mandible and maxilla in three planes of reference: axial, panoramic, and oblique sagittal (or cross-sectional). The clarity and identical scale between the various views permits uniformity of measurements and cross-referencing of anatomic structures through all three planes. Unlike previous imaging techniques, the oblique sagittal view permits the evaluation of distinct buccal and lingual cortical bone margins, as well as clear visualization of internal structures, such as the incisive and inferior alveolar canals. Several case reports are presented to demonstrate the clinical usefulness of DentaScan.

Adult↗
PubMedDate not supplied

Toxicity of chelated mercury.

The oral and iv acute toxicities of several mercury chelates were determined in mice in a search for relationships bearing on the effectiveness of various chelating agents in therapy. It was found that the toxicity was independent of the stability constant for the mercury chelate when the toxicity was expressed on a molar basis. For the mercury chelates of sulfhydryl containing chelating agents, the oral toxicity was unexpectedly low, presumably due to the poor absortion of these materials from the G.I. tract. The results suggest that the toxicities of mercury complexes are independent of the stability constant of the complex over the range of stability constant from 10(23) on down, provided chelation does not drastically alter the distribution of the complex in the body.

Animals↗