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Biomedical subjects

C D Fletcher

Publications and source records attributed to C D Fletcher.

At least 307 records · Page 17Linked to original sources
PubMed1987

Not tarsal tunnel syndrome: a malignant "Triton" tumour of the tibial nerve.

A 23 year old male patient presented with a venous thrombosis in the right calf. This was followed by symptoms, signs and electromyographic findings suggestive of a tarsal tunnel syndrome. Symptoms were briefly relieved by surgical division of the flexor retinaculum. Subsequently, patient developed swelling in the calf and was found to have a malignant ("Triton") tumour of the tibial nerve and required above knee amputation. In the absence of obvious foot or ankle deformity, caution should be exercised in making the diagnosis of tarsal tunnel syndrome.

Adult↗
PubMed1987

Visceral intravascular capillary hemangioma.

In the course of routine pathologic examination of an ovarian serous cystadenoma excised from a 35-year-old woman, an intravascular mass in the cyst capsule was noted. Histologically, this was found to be an intravenous capillary hemangioma. To our knowledge, no such lesion has been previously reported. The relationship of this lesion to intravenous pyogenic granuloma and features by which the two may be distinguished are discussed. Other primary intravascular endothelial tumors are briefly reviewed.

Adult↗
PubMed1986

Lipoprotein and apoprotein levels in postmenopausal women during treatment with norethisterone.

Lipoprotein and apolipoprotein levels were monitored in 21 postmenopausal women during 6 months' treatment with norethisterone. There was no significant change in low density lipoprotein (LDL) cholesterol but apoprotein B levels rose significantly (p less than 0.001) thus increasing the apoprotein:cholesterol ratio in LDL. High density lipoprotein (HDL) cholesterol levels decreased significantly (p less than 0.001) in the first two months and did not change significantly thereafter. The HDL2 subfraction was reduced to a greater extent than the HDL3 subfraction. Apoprotein AI and AII levels were both reduced as was the apoprotein AI:AII ratio. The ratios of apoproteins AI and AII to HDL cholesterol were increased. We conclude that norethisterone has an adverse effect on the important risk factors for cardiovascular disease.

Adult↗
PubMed1986

Effects of ranitidine and cimetidine on plasma lipoproteins in healthy subjects.

Serum lipoproteins were monitored in 24 healthy subjects receiving either ranitidine or cimetidine for four weeks. Ranitidine produced a significant (P less than .05) reduction in high-density lipoprotein (HDL)-cholesterol in both men and women. Cimetidine caused a nonsignificant increase in HDL-cholesterol and a reduction in LDL-cholesterol that was significant (P less than .05) only in women. As these drugs had opposite effects on HDL-cholesterol levels, the mechanism of action is unlikely to be medicated by H2-receptor blockade.

Adult↗
PubMed1986

Nasal glioma. A rarity.

Nasal glioma is a rare congenital malformation which most often presents to the otorhinolaryngologist or neurosurgeon. However, occasional cases of the extranasal variant are referred to a dermatologist as an unusual subcutaneous mass over the bridge of the nose, most often in an infant. These lesions may not be recognised clinically, leading to dangerous mismanagement, and may be misinterpreted by pathologists as a neoplasm, either benign or malignant. Three cases are described here with the purpose of focussing the attention of workers in dermatology on this unusual developmental abnormality.

Female↗
PubMed1986

Dermal nerve sheath myxoma: a study of three cases.

Three cases of dermal nerve sheath myxoma have been studied by light microscopy, histochemistry and immunohistochemistry. The pertinent literature has been reviewed. This lesion, which is a rare benign tumour of probable nerve sheath origin, arises most often in young adults and shows a predeliction for females. Histologically it has a characteristic appearance. Histochemically, the heteroglycan content of the mucoid matrix is more in keeping with a cartilaginous lesion. The histogenesis and differential diagnosis are discussed.

Adult↗
PubMed1986

Soft tissue chondroma--a study of 15 tumours.

Fifteen cases of soft tissue chondroma have been reviewed. This lesion shows an equal sex incidence and occurs predominantly in middle-aged individuals. The majority arise in the hands and feet. Histologically these tumours are largely composed of adult-type hyaline cartilage, but in all cases foci show nuclear atypia and pleomorphism. In cartilaginous lesions of the axial skeleton or large limb bones this would probably have led to a diagnosis of well differentiated chondrosarcoma. Despite these worrying features none of the seven cases for which follow-up information is available recurred. The importance of recognizing the benign nature of these little-known tumours is stressed. The differential diagnosis of soft tissue cartilaginous tumours is briefly discussed.

Adolescent↗
PubMed1986

Extraskeletal myxoid chondrosarcoma: a histochemical and immunohistochemical study.

In reviewing a large series of soft tissue sarcomas, nine cases of extraskeletal myxoid chondrosarcoma have been retrieved. These tumours, which principally presented in middle-aged adults, have been examined histochemically to determine the heteroglycan content of their myxoid matrix and immunohistochemically for the presence of S-100 protein. The principal mucopolysaccharides identified were chondroitin-4 and 6-sulphate and keratan sulphate; each of the tumours was S-100 positive. The relevance of these findings to the histogenesis and differential diagnosis of these uncommon neoplasms is discussed.

Adult↗
PubMed1986

Multicentric extra-abdominal 'myofibromatosis': report of a case with ultrastructural findings.

A case of multicentric extra-abdominal fibromatosis, a rare entity, arising in a young female is presented. Three separate lesions developed in the same limb over a period of 11 years, one of which recurred on two occasions. Electron microscopy of the most recent tumour showed a predominance of myofibroblasts. The literature regarding extra-abdominal fibromatosis is reviewed and discussed. Redesignation of both abdominal and extra-abdominal fibromatoses as myofibromatoses is suggested.

Abdomen↗
PubMed1986

Benign plexiform (multinodular) schwannoma: a rare tumour unassociated with neurofibromatosis.

In reviewing a large series of soft tissue tumours, seven cases of benign plexiform schwannoma have been retrieved. These were solitary lesions, not associated with von Recklinghausen's neurofibromatosis, which arose in the dermis or subcutaneous tissue, predominantly in young adults. None has recurred. While the schwannomatous nature of these rare lesions is readily appreciated, the frequent presence of nuclear pleomorphism and the plexiform growth pattern should not be regarded as having sinister prognostic significance.

Adult↗
PubMed1986

Fibroma of tendon sheath: a clinicopathologic study.

Thirteen cases of fibroma of tendon sheath have been reviewed. This lesion presents predominantly in middle-aged adults, particularly men, and usually arises in the dermis and subcutis of the extremities, most especially the hands. Histologically these tumours are always well circumscribed and may be lobulated. They are largely composed of interlacing bundles of hyalinised, hypocellular fibrous tissue with occasional more cellular areas. A constant feature is the presence of slit-like vascular channels. They are benign lesions with little tendency to recur and, although becoming more generally recognised are not yet familiar to dermatologists.

Adolescent↗
PubMed1986

Long-term hormone implant therapy--effects on lipoproteins and steroid levels in post-menopausal women.

Lipoprotein and steroid hormone levels were measured in 61 bilaterally oophorectomised women who had been treated for 3 years with implants containing either oestradiol alone or oestradiol plus testosterone. The lipoprotein levels associated with each of the two therapy regimens were compared. In addition, lipoproteins were measured in 67 untreated bilaterally oophorectomised age-matched women and compared with those of the treated women. Despite the high oestradiol levels produced by both types of implant, the only significant finding was a reduced LDL cholesterol in the oestrogen/testosterone treated group as compared with that of the untreated group.

Adult↗
PubMed1986

The effects of conjugated equine oestrogens with and without a cyclical progestogen on lipoproteins, and HDL subfractions in postmenopausal women.

Serum lipoprotein levels were followed for 24 weeks in 21 oophorectomised women treated with conjugated equine oestrogens (0.625 mg/day) and 21 women who had had a natural menopause and were treated with a combined preparation consisting of conjugated equine oestrogens (0.625 mg/day) with the addition of dl-norgestrel (0.15 mg/day) for the last 12 days of each treatment cycle. Conjugated equine oestrogens caused a significant (P less than 0.05) increase in triglyceride, HDL cholesterol, especially HDL2 cholesterol, and a significant decrease (P less than 0.05) in LDL cholesterol. Those subjects treated with conjugated equine oestrogens plus cyclical norgestrel showed a significant (P less than 0.05) decrease in LDL cholesterol levels only.

Cholesterol↗
PubMed1985

Is tissue copper deficiency associated with aortic aneurysms?

It has been suggested that patients with abdominal aortic aneurysms are deficient in tissue copper. Levels of copper and zinc in liver and aortic wall were therefore measured in 11 patients with aortic aneurysms and 11 fresh cadavers with normal aortas. The concentrations of copper were similar in both groups. Zinc concentration was higher in the normal aortic wall, probably because of the greater thickness of the media in the normal aorta. We found no evidence that aortic aneurysms are associated with reduced tissue copper concentrations.

Aged↗