Biomedical subjects

C D Chisholm

Publications and source records attributed to C D Chisholm.

23 records · Page 2Linked to original sources

PubMed1989

Preliminary observations on the effects of hyperbaric oxygen therapy on western diamondback rattlesnake (Crotalus atrox) venom poisoning in the rabbit model.

Intermittent hyperbaric oxygen therapy has been shown to reduce skeletal muscle necrosis in a compartment syndrome animal model. To study whether intermittent exposure to hyperbaric oxygen augments antivenin therapy in reducing muscle necrosis, we injected sublethal doses of Western Diamondback rattlesnake (Crotalus atrox) venom intramuscularly into the hind legs of New Zealand White rabbits. In this pilot study, the animals were divided into three treatment groups. The first group received one vial of antivenin intravenously, the second group received one vial of antivenin intravenously plus three hyperbaric oxygen treatments, and the third group received no treatments. There were no statistically significant differences among the groups. These preliminary observations suggest that muscle necrosis secondary to Crotalus atrox venom poisoning is not significantly altered either by Antivenin [Crotalidae] Polyvalent at the dose level we used or in combination with intermittent hyperbaric oxygen treatments in this rabbit model.

Animals↗

PubMed1989

Plantar puncture wounds: controversies and treatment recommendations.

Future studies are needed to define the natural history of plantar puncture wounds; delineate optimal initial evaluation techniques; examine the role of broad-spectrum antimicrobials for prophylaxis; treatment, or both; and investigate optimal therapy for immunocompromised patients.

Anti-Bacterial Agents↗

PubMed1987

Ischemic injury to the spinal cord as a cause of transient paraplegia.

Spinal cord ischemia presenting as acute paraplegia is an uncommon occurrence not previously reported in the emergency medicine literature. Paraplegia due to spinal ischemia is seen most commonly after intraoperative aortic manipulation; however, acute hypotension and prolonged cardiopulmonary resuscitation are also reported settings. The differential diagnosis of acute, non-traumatic paraplegia includes mechanical spinal cord compression, acute transverse myelitis, and polyneuritis.

Acute Disease↗

PubMed1984

Effect of the pneumatic antishock garment on intramuscular pressure.

Recent case reports implicate pneumatic antishock garment (PASG) usage in subsequent development of compartment syndromes. The anterior tibial compartment pressures of eight healthy volunteers were selected for study at varying PASG inflation pressures. A wick catheter method provided continual intramuscular compartment pressure (IMP) monitoring throughout the period of study. A linear correlation between PASG pressure and IMP exists, with more than 90% of the externally applied pressure being transmitted to the muscle compartment. All subjects developed IMP greater than 50 mm Hg at PASG inflation of 60 mm Hg. Externally applied pressure appears to create a condition that may stimulate or lead to a compartment syndrome. Inflation pressure should be monitored closely during PASG application, because IMP can be assumed to be at least as high as inflation pressure. The lowest effective PASG pressure should be used.

Adult↗

PubMedDate not supplied

A rare etiology for pulmonary embolism: basilic vein thrombosis.

A 61-year-old white male with recurrent thrombophlebitis developed a painful left arm. He was initially diagnosed with superficial thrombophlebitis and treated conservatively for several days without improvement. He subsequently developed right-sided pulmonary embolism. Hypercoagulability was not present, and venography confirmed the left basilic vein as the sole thrombogenic source. Twelve to twenty percent of documented pulmonary emboli arise from deep veins of the upper extremity. To our knowledge, only one case of basilic vein thrombosis causing pulmonary embolism exists in the literature. Clinical vigilance to this uncommon entity may reduce attendant morbidity and mortality.

Arm↗