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Biomedical subjects

C D Brown

Publications and source records attributed to C D Brown.

At least 109 records · Page 6Linked to original sources
PubMed1981

Afferent loop syndrome revisited: new emphasis on ultrasound and computerized tomography.

Contemporary medicine has provided the clinician with two additional noninvasive diagnostic instruments--computerized tomography and ultrasound. Both modalities are accessible to most clinicians and are extremely valuable in diagnosing many abdominal diseases. A review of the afferent loop syndrome and a discussion of new diagnostic methods with these instruments are presented.

Afferent Loop Syndrome↗
PubMed1980

Specific immunoglobulin M response to hepatitis A virus determined by solid-phase radioimmunoassay.

Immunoglobulin M antibody to hepatitis A virus (IgM anti-HAV) is found in most patients with acute type A hepatitis. To determine the duration of this IgM response as well as to confirm that IgM anti-HAV is a specific marker for acute infection, we developed a solid-phase radioimmunoassay for IgM anti-HAV. This new assay is 25-fold more sensitive than a conventional blocking radioimmunoassay for anti-HAV, and interference due to rheumatoid factor was eliminated by simultaneously testing sera against virus-free control antigen. Maximum IgM anti-HAV titers (1:6,400 to greater than or equal to 1:51,200) were detected during the first 30 days after the onset of illness. Although the IgM anti-HAV titer subsequently declined 64-fold over the ensuing 90 days, low-titer IgM anti-HAV (1:100 to 1:400) persisted in many sera for 90 to 150 days. Acute sera having an IgM anti-HAV titer of greater than or equal to 1:25,600 possessed a significantly higher mean IgM concentration (492 mg/dl) than acute sera with an IgM anti-HAV titer of less than or equal to 1:12,800 (344 mg/dl; P < 0.05). IgM anti-HAV titers did not correlate with other clinical or laboratory measures of disease severity. Detection of IgM anti-HAV proved to be both a highly specific (>99%) and a sensitive (>99%) method for the diagnosis of type A hepatitis.

Animals↗
PubMed1978

Postmortem intravascular bubbling: a decompression artifact?

The relationships between drowning occurring in divers using compressed air, with subsequent recovery of the body to the surface, and the finding of intravascular gas bubbles at autopsy were studied. Guinea pigs were exposed to compressed air in a hyperbaric chamber at various depths [98, 294, and 392 kPa (1,3, and 4 atm)] for various intervals and then drowned at depth. Various decompression schedules were used in returning the drowned animals to the surface. Autopsy examination indicated that large and small intravascular gas bubbles may be found, in the absence of traumatic air embolism or decompression sickness, as a result of the process of decompression alone. Postmortem findings of intravascular bubbles bin drowned divers must be interpreted with caution and the importance of a full history of the incident, including depth and time of diving and evidence of ascent before drowning, are critical to the proper interpretation of intravascular gas bubbles.

Animals↗