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Biomedical subjects

C D Binnie

Publications and source records attributed to C D Binnie.

At least 163 records · Page 9Linked to original sources
PubMed1976

The contingent negative variation and psychological findings in chronic hepatic encephalopathy.

Early diagnosis of chronic hepatic encephalopathy (CHE) in the latent stage before the appearance of clinical signs, should reduce both morbidity and mortality as deterioration is often preventable by treatment. Since existing diagnostic procedures are inadequate, we have investigated a test in which morphine is used as a provocative agent and any resulting change in cerebral function assessed by measurement of the CNV in conjuction with a psychological trail test. Twenty six patients were studied, 6 of whom had clinically overt CHE. A significant correlation (P less than 0.05) between the change in CNV amplitude with morphine and the initial CNV amplitude, consistent with the theoretical model of Tecce (1972), was found. However, the CNV and trail test results taken as a whole did not allow even those patients with overt CHE to be distinguished and we conclude that it is unlikely that differing degrees of latent CHE could be detected.

Chronic Disease↗
PubMed1976

Feasibility studies of evoked response audiometry in the mentally subnormal.

Evoked response audiometry was attempted on a group of seventy-seven unsedated severly subnormal patients up to the age of twenty-two years. Data of some clinical value were obtained in fifty-seven cases. It is suggested that sedation need only be used if the initial attempt at E.R.A. is unsuccessful. Over twenty per cent of the subjects appeared to have significant hearing loss.

Acoustic Stimulation↗
PubMed1973

Electroencephalographic changes in epileptics while viewing television.

Ten consecutive epileptic patients who showed abnormal electroencephalographic (E.E.G.) responses to intermittent photic stimulation have been studied while watching television. Though only two gave a history of television epilepsy nine exhibited spike-wave discharges in the E.E.G. during viewing. This effect occurred when the set was functioning normally but was increased in five subjects when the screen was deliberately caused to flicker.

Adolescent↗
PubMed1970

Electroencephalographic prediction of fatal anoxic brain damage after resuscitation from cardiac arrest.

Ninety-three electroencephalograms (E.E.G.s) were recorded within a week of cardiac resuscitation from 41 patients in whom the subsequent outcome was known to be either recovery of cerebral function or death with associated pathological evidence of gross anoxic brain damage. A statistical analysis of observations on these E.E.G.s yielded a discriminant function for predicting death or survival. Predictions based on each of the 93 individual E.E.G.s would have been correct in 92 and at a confidence level better than 99%. The same discriminant function was found to be applicable to a further 19 patients who died but did not undergo neuropathological studies and to 33 others in whom the clinical picture was complicated by such factors as uraemia or head injury. Thus it seems that the presence or absence of fatal brain damage after cardiac arrest can be reliably predicted from E.E.G.s taken within a week of resuscitation. An estimate of the probability of survival is now routinely included in the clinical report on each E.E.G. taken after cardiac arrest.

Adolescent↗
PubMedDate not supplied

Significance and management of transitory cognitive impairment due to subclinical EEG discharges in children.

Epileptiform EEG discharges not accompanied by obvious clinical events are generally regarded as subclinical or interictal. However, in many patients suitably sensitive methods of continuous psychological testing demonstrate brief episodes of impaired cognitive function during such discharges. This phenomenon of transitory cognitive impairment (TCI) is found in some 50% of those patients who exhibit discharges during testing. With focal discharges, the effects are material specific, the deficit being demonstrable only with tasks involving that hemisphere in which the discharge occurs. It is probable that TCI contributes to the known cognitive problems of many people with epilepsy, and indeed causes deficits which are not readily recognised. Thus TCI may be found in benign epilepsy of childhood, a condition believed specifically not to be associated with psychological problems. An important practical issue is whether TCI materially impairs day to day psychosocial function and if so whether drug treatment is either desirable or effective. A preliminary controlled trial of antiepileptic treatment of TCI is described: suppression of discharges was associated with significant improvement in psychosocial function.

Child↗