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Biomedical subjects

C D Bedetti

Publications and source records attributed to C D Bedetti.

27 records · Page 2Linked to original sources
PubMed1983

Löffler's endocarditis. Occurrence with malignant lymphoma with a high content of epithelioid histiocytes ('Lennert's lymphoma').

In a patient who had malignant lymphoma with a high content of epithelioid histiocytes (so-called Lennert's lymphoma), Löffler's endocarditis developed 18 months after her diagnosis of lymphoreticular malignant neoplasm. She died of refractory congestive heart failure, and an autopsy showed the typical gross and microscopic findings of Löffler's endocarditis. To our knowledge, this is the first reported association of these two diseases. We noted nine autopsy cases in the literature of Löffler's endocarditis occurring in patients with lymphoreticular malignant neoplasms (acute lymphoblastic leukemia and lymphoma). Löffler's endocarditis with eosinophilia may be a relatively uncommon but significant complication in patients with malignant lymphoproliferative disorders. The peripheral blood eosinophilia probably represents a reactive response to tumor antigen.

Autopsy↗
PubMed1981

Right splenorenal fusion with associated hypersplenism.

We report the second case of splenorenal fusion and the first occurrence of spleen fusion associated with a right retroperitoneal structure. Hypersplenism was cured by removal of the mass. A concomitant renal cell carcinoma and multiple adenomas within the mass were incidental clinical features. Aside from the rarity of the lesion, its documented occurrence on the right side is significant in that it provides evidence for the possible migration of spleen cells in embryogenesis as an explanation for some other splenic fusion anomalies.

Adenocarcinoma↗
PubMed1980

The development of non-Hodgkin's lymphoma following therapy for Hodgkin's disease.

Three patients developed non-Hodgkin's lymphoma (NHL) 3-6 years after treatment for Hodgkin's disease (HD). In no instance was there evidence of recurrence of HD following the initial chemotherapy or radiotherapy. None of these patients had received both radiation therapy and chemotherapy. The histologic classification of the developing of the developing NHL for the three patients was (1) diffuse, poorly differentiated lymphocytic, (2) nodular histocytic, and (3) nodular, poorly differentiated lymphocytic. In no instance was there any histologic similarity to the original HD. Perhaps most important with respect to histology was the easily demonstrable presence of Reed-Sternberg cells at the time of original diagnosis and their absence with onset of NHL. All patients responded well to conventional chemotherapy for NHL and are alive at 23+, 37+, and 65+ months after that secondary diagnosis. This report, when coupled with at least ten other such reported patients, suggests that NHL may be a relatively uncommon but significant complication of therapy for HD and must be distinguished for recurrence of HD.

Antineoplastic Agents↗
PubMed1978

Teflon felt embolism of coronary arteries after cardiac surgery: a case report.

A case is presented of fatal coronary embolism of Teflon felt used to buttress sutures in the placement of a Björk-Shiley aortic valve prosthesis. The embolism occurred on the tenth postoperative day, lodging in the left anterior descending branch of the left coronary artery 5.5 cm. from the ostium, causing a large anterior myocardial infarct. The patient died in less than 24 hours following the infarct. A review of the literature indicates that this is the first reported case of clinically significant embolism of Teflon felt used in the placement of a Björk-Shiley aortic valve.

Coronary Disease↗
PubMed1975

Influence of the hypophysis on mitochondrial protein synthesis.

Hypophysectomy significantly decreased the capacity to synthesize protein by isolated liver and skeletal muscle mitochondria. Total hypophyseal extract, growth hormone or thyroxine administered to the whole animal in adequate doses prior to sacrifice enhanced protein synthesis to values similar or higher to those of the control, especially in the case of thyroxine.

Animals↗
PubMedDate not supplied

Prevalence of thyroid abnormalities is not increased in Alzheimer's disease.

The aim of this study was to compare the prevalence of pathologically and clinically documented thyroid disorders in patients with Alzheimer's disease (AD) and nondemented individuals. We reviewed the records of 31 patients with a pathological diagnosis of AD and 31 age-matched nondemented patients selected from autopsy files. We examined the pathological findings in the thyroid gland in both groups. Twenty-four cases (77.4%) with AD and 21 patients (67.7%) in the control group showed pathological abnormalities in the thyroid gland. The prevalence of specific types of thyroid gland abnormalities on pathological examination did not differ significantly between the AD and nondemented cases. For the 19 AD and 18 control patients in whom clinical thyroid function had been documented adequately during life, the percentage of patients with abnormal thyroid function was similar in the AD (15.7%) and control (11.1%) groups. These results do not support a relationship between AD and thyroid abnormalities.

Aged↗