Brain folate concentration in folate-deficient rats receiving diphenylhydantoin.
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Animals↗
Biomedical subjects
C D Allen
Publications and source records attributed to C D Allen.
Omental transposition to brain of stroke patients.
The intact omentum was transposed to the surface of the brain in three aphasic patients who had stabilized following a dominant hemisphere ischemic stroke. The procedure was found to be safe, causing little physical disfigurement. Subjective and objective improvement in these patients, who are on a strict experimental protocol, has provided encouragement to continue this study in a deliberate and critical manner.
Adult↗
Toxicity of chronic spinal analgesia in a canine model: neuropathologic observations with dezocine lactate.
The chronic spinal toxicity of dezocine lactate was investigated in mongrel dogs. Dogs received chronic intrathecal infusion from implanted infusion pumps for 28-136 days. Infusion of saline via intrathecal catheters produced leptomeningeal fibrosis, sometimes with spinal cord compression. Dezocine lactate infusion, in addition to similar leptomeningeal changes, was also associated with severe parenchymal lesions in all cases. The exact cause of this toxicity cannot be specifically assigned; potential contributing factors include catheter-induced reaction, pH of the drug, lactate concentration, osmolality and the pharmacologic agent itself. Leptomeningeal reaction in control dogs limits the value of chronic intrathecal dog models for assessment of spinal drug toxicity.
Analgesics, Opioid↗