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C Croce

Publications and source records attributed to C Croce.

44 records · Page 3Linked to original sources
PubMed1978

Studies on the association of the Epstein-Barr virus genome with chromosomes in human (Burkitt)/mouse hybrid cells.

We have used somatic-cell hybrids of mouse fibroblast and Burkitt's lymphoblastoid tumour cells to continue our investigation of the association between Epstein-Barr virus (EBV) genome and human chromosomes. A mouse/Burkitt hybrid cell, designated CL1D/HR-1, was cloned in soft agar. Each of 10 clones was assayed for the spontaneous expression of EBV-associated nuclear antigen (EBNA), early antigen (EA) and virus capsid antigen (VCA). Six of 10 clones were EBNA-positive but negative for EA and VCA even after treatment with iododeoxyuridine. One clone, designated M44, contained approximately 90% EBNA-positive cells and 0.3--0.5 EBV genome equivalents per cell. Thirty subclones of clone M44 were obtained and analysed for EBV DNA, EBNA and human chromosomes. Four subclones (three EBNA-positive and one EBNA-negative) were studied in detail. Data obtained thus far indicate that none of the four subclones of clone M44 studied contained any intact human chromosome. Isozyme analysis of these subclones indicated that all four subclones, regardless of the status of the EBV genome, synthesized nucleoside phosphorylase, an enzyme which has been linked to human chromosome number 14.

Animals↗
PubMed1977

Cell fusion.

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Cell Fusion↗
PubMed1977

Influence of cortisone and cyclophosphamide on xanthine oxidase bacterial activation.

The xanthine oxidase increase in mice liver as response to infection was studied as a possible parameter useful for a better understanding of theimmunosuppression due to cyclophosphamide and cortisone. An impact of cortisone but not of cyclophosphamide on this mechanism was found; this may be useful in order to discriminate between the two different types of immunosuppressive drugs.

Animals↗
PubMedDate not supplied

Outcome of 118 pancreas transplants with retroperitoneal portal-enteric drainage.

BACKGROUND: We have recently described a technique for retroperitoneal pancreas transplantation (RPTx) with portal-enteric drainage (PED). Further experience with 118 RPTx is detailed herein. METHODS: Between April 2001 and August 2004, 118 patients underwent RPTx with PED among 125 recipients (94.4%) scheduled for this procedure. Surgical complications and patient and graft survivals were recorded prospectively. RESULTS: After a minimum follow-up period of 3 months (mean 27.8 +/- 13.0 months), 18 recipients (15.2%) required relaparotomy because of bleeding (n = 6; 5.1%), allograft pancreatectomy due to either hyperacute/accelerated rejection (n = 3; 2.5%) or vein thrombosis (n = 3; 2.5%), leak from duodenojejunal anastomosis (n = 2; 1.7%), bleeding and vein thrombectomy (n = 1; 0.8%), or small bowel occlusion due to bezoar (n = 1; 0.8%). One patient had a negative relaparotomy and one underwent two relaparotomies. Most patients with hemorrhage (5/7; 71.4%) were recipients of solitary pancreas grafts managed with heparin infusion. No venous thrombi extended into recipient's superior mesenteric vein. Nonocclusive venous thrombosis was diagnosed with duplex ultrasonography and confirmed at computed tomography in seven patients (5.1%). None of these patients lost graft function. Ten patients (8.5%) were diagnosed with peripancreatic fluid collections, all successfully treated by observation (n = 7) or percutaneous drainage (n = 3). Enteric bleeding occurred in eight recipients (6.8%). Overall, 1-year patient and pancreas survival rates were 97.4% and 92.0%, respectively. CONCLUSIONS: We conclude that RPTx with PED is a technical option that may be included in the repertoire of pancreas transplant surgeons.

Anastomosis, Roux-en-Y↗