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Biomedical subjects

C Cornu

Publications and source records attributed to C Cornu.

98 records · Page 6Linked to original sources
PubMedDate not supplied

[Pharmacology of estrogens and progestogens and cardiovascular risk].

The rationale for oestrogen replacement therapy relies mainly on two types of evidence, both of which are flawed: (1) the relative protection of women in premenopausal status against cardiovascular diseases and the increase of risk following menopause; (2) data from observational studies that showed a lower prevalence of cardiovascular events in women taking hormone replacement therapy (HRT) compared with those not taking such treatment (OR = 0.65; 95 per cent CI: 0.59-0.71). Behind the former evidence there is the assumption that the difference in risk before and after menopause is mostly due to the lack of ovarian oestrogens in post-menopausal women. This is indeed a strong assumption since there are many other changes during and after menopause. The second type of evidence assumes that the ORs given by the observational studies are unbiased. In fact, there are reliable data suggesting that women taking and not taking HRT are different in many respects, especially in their concerns for their health. This dimension has been proposed as an explanation for the correlation between compliance with placebo and survival. The only reliable approach is to perform adequately sized and long-term follow-up randomized trials. Although they should not be viewed as conclusive, the results of the first completed trial do not support the hypothesis that HRT is beneficial in women with a history of coronary disease.

Cardiovascular Diseases↗
PubMedDate not supplied

[Ligation of lymphatic ducts in treatment of arteriosclerosis. 550 operated cases reported over a period of 9 years].

In all diseases where there is an important loss of lymph, e.g. chylothorax, chyloperitoneum, exsudative enteropathy chyloduodenal fistula, we observed not only a fall in the serum proteins and calcium, but also a fall in lipids and cholesterol. We first carried out ligature of the lymphatic ducts in numerous dogs. Since 1966, we have carried out this ligature in 550 arteriosclerotic patients, aged less than 52 years. The metabolic changes observed over a period of 9 years were very marked. Clinically, in 100 patients who underwent classical reconstructive arterial surgery, the association of ligature of the lymphatic ducts reduced by half, after a period of 6 years, the complications normally observed.

Arteriosclerosis↗
PubMedDate not supplied

[Controlled clinical trial and homeopathic treatment of ORL and recurrent respiratory tract infections in children: preliminary survey of homeopathic physicians].

We performed a survey to assess the feasibility of a placebo-controlled clinical trial of the treatment of recurrent ENT/respiratory tract infections in children, to assess the diversity of the drugs prescribed, and the acceptability of a clinical trial to homeopathic physicians. A mailed questionnaire was sent to 237 homeopathic physicians, asking for details of prescriptions for 10 consecutive children consulting for ENT/respiratory recurrent infections, and for two simulated cases. We also asked for their opinion about homeopathic treatment evaluation. Only 48 (20 per cent) questionnaires were returned completed. These gave 309 different acute treatments and 422 different preventive treatments for the 10 consecutive patients and 87 different prescriptions for the simulated cases. A total of 467 different drugs were used. The physicians who replied were favourable to the evaluation of homeopathic drugs, reluctant for the use of a placebo; and they would like to receive training in drug evaluation. Setting up a clinical trial in this field would require specific methodological and logistical adaptations, and a detailed training programme for the homeopathic doctors beforehand.

Child, Preschool↗