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Biomedical subjects

C Cordiano

Publications and source records attributed to C Cordiano.

At least 19 recordsLinked to original sources

Benign cystic mesothelioma in a male patient: surgical treatment by the laparoscopic route.

We report a case of a benign cystic mesothelioma in a 44-year-old man. The patient was asymptomatic, and the cystic formation was discovered by chance in the course of ultrasonography for urological disorders. Benign cystic mesothelioma is a rare pathology, and only 19 cases have been described in male patients. The differential diagnosis versus other cystic diseases can only be defined histologically and is of critical importance to clinical management. Surgery is mandatory for both diagnosis and treatment. In the case reported here, a minimally invasive laparoscopic approach allowed not only histological diagnosis of benign cystic mesothelioma, but also its surgical treatment by the same route.

Adult

Acute cholecystitis: ultrasonographic staging and percutaneous cholecystostomy.

Experience in the treatment of acute cholecystitis with percutaneous cholecystostomy in 29 high-risk and elderly patients is reported. The treatment group included 14 men and 15 women, 21 of whom were over 70 years of age. The suspected clinical diagnosis of acute cholecystitis was confirmed in all cases by ultrasonography (accuracy: 95.6%). The percutaneous cholecystostomy was successful in 27 of 29 cases and these patients had a sudden improvement in their clinical condition; failure of the procedure was due in one patient to dislodgement of the catheter and in another patient to the guide-wire slipping out of the gallbladder. Six patients complained of pain radiating to the right shoulder which disappeared within 30-60 minutes after the procedure. Twenty-three of the 27 patients subsequently underwent elective cholecystectomy. In 22 patients the ultrasonographic findings were compared with the histology; thus enabling us to establish an ultrasonographic staging of acute cholecystitis related to the seriousness of the disease. Percutaneous cholecystostomy is the treatment of choice in high-risk patients, in the elderly, as well as in young patients with impending perforation.

Acute Disease

[Staging of gastric carcinoma].

The controversies over the patterns of gastric cancer staging in western countries (UICC-AJCC), Japan (JRSGC) and more recently Hawaii (1984) are analysed with reference to the problems of definition and assignment of values to the single elements: T,N,M, location and stage grouping that were not homogeneously established in the patterns mentioned. Problems about T mainly regard T1 and T4. T1 incorporates tumours (T1m and T1sm) with quite different prognosis and therefore represents, in spite of several changes made, a dyshomogeneous group. The same can be said about T4 where prognoses are considerably different according to contiguous structures involved in the tumour and they are not held in due consideration by the various staging systems. In all these, the different lymph nodes are gathered into homogeneous groups (N1,N2,N3) progressively numbered according to the prognostic value. These groups are based, however, on inadequate information and in fact constitute heterogenous umbrellas. The greatest problems about parameter M concern subclinical M1 that, missed at the time of the tumours staging before or during operations, reveal themselves shortly after operations considered radical. Finally new views about the relationship between cancer biology and prognosis (cytofluorometry, immunohistochemistry, etc.) are examined.

Humans

Fat infusion and blood coagulation in patients undergoing surgery for esophageal cancer.

Twenty-six patients with stage III and IV esophageal cancer were randomly studied to evaluate the influence of fat emulsions (Intralipid) infusion on blood coagulation during total parenteral nutrition (TPN). The patients were divided into two groups: the first group (13 patients) received 24h. TPN; in the second group (13 patients) 1000 ml of 10% Intralipid were added to TPN via a peripheral vein over a period of 12 h. (1.8-2.1 g/kg/day). Primary hemostasis, platelet adhesiveness, alterations in fibrin formation and risk factors were evaluated before treatment (Time 0), after 7 days (Time 1) and after 14 days (Time 2). Statistical analysis of results was also carried out. On the basis of the obtained results it is observed that Intralipid at the administered doses, did not cause any alterations in blood coagulation and particularly in platelet adhesiveness.

Blood Coagulation

Esophagectomy and esophageal replacement by gastric pull-through procedure.

The gastric pull-through procedure is a relatively new surgical technique for carcinomas of the hypopharynx and cervical esophagus and benign diffuse stricture of the thoracic esophagus, that require total esophagectomy. This technique is original both in the exeretic and reconstructive phase: total esophagectomy is performed by blunt dissection; thoracotomy and pleural damage are avoided. The basic principle of the operation is the gastric transposition into the neck through the posterior mediastenum and a pharyngogastric or esophagogastric anastomosis, according to the type of disease. Fourteen of our cases who underwent a gastric pull-through are presented and discussed.

Carcinoma

Carcinoembryonic antigen and cancer: a comparative study.

The sera of 212 patients with malignant and non-malignant diseases have been radioimmunoassayed for the presence of the carcinoembryonic antigen (CEA) using 3 different kits produced of Hoffman La Roche, Switzerland (RCK), BY Sorin-IRE, Italy and Belgium (SCK), and by the Istituto Sieroterapico Milanese, Italy (ICK). In the presence of endodermically-derived system carcinomas, the RCK gave more positive results (72.6%) than did the SCK (63.1%) or ICK (56.2%). With regard to other carcinomas, ICK (50.0%) and SCK (47.1%) gave better results than did RCK (30.6%). The results are discussed in terms of clinical usefulness of the CEA assay and as regards reproducibility, procedural advantages, and economical cost of each kit. It is concluded that the CEA assay cannot be used for the diagnosis of gastrointestinal cancers, although it is useful as a measure of "cancerosity" for prognostic purposes. In this sense the double antibody method employed by SCK and ICK is clinically more advantageous than is the perchloric acid extraction-zirconyl phosphate gel precipitation method of RCK.

Carcinoembryonic Antigen

Postoperative chylothorax. Six cases in 2,500 operations, with a survey of the world literature.

We have systematically reviewed the literature concerning iatrogenic chylothorax and shall report our personal observations on the subject. Despite an increasing number of thoracic operations, injuries to the thoracic duct are infrequent. Cardiovascular and esophageal procedures are the most frequent causes of chylothorax. Malformations of the thoracic duct and other organs of the mediastinum have often been involved in lymphatic injury. Consequently, we believe that a complicating chylothorax may result from varied causes rather than solely from a surgical error.

Adolescent