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Biomedical subjects

C Cope

Publications and source records attributed to C Cope.

At least 73 records · Page 4Linked to original sources

Needle endoscopy in special procedures.

A needle endoscope, with a rigid shaft 2.2 mm wide and 20 cm long, an illumination range of 2-4 cm, and excellent optics, has proved to be very valuable in performing special interventional procedures because it can be inserted in any relatively straight 7-F catheter track. The needle endoscope has been very useful in combination with fluoroscopy for retracing lost drain tracks, evaluating fistulas and sinuses, performing limited pleuroscopy and laparoscopy for biopsy under direct vision, and evaluating the gallbladder and renal pelvis for location of duct openings. The author describes techniques used with the needle endoscope and results in a sample of cases. There has been no morbidity associated with the use of the instrument in over 800 examinations in a 12-year period.

Endoscopes↗

Transcatheter biopsy of lesions obstructing the bile ducts.

A method was developed for biopsy sampling of masses obstructing the biliary system in patients with a biliary drainage catheter. The biopsy needle is inserted through the drainage catheter, with fluoroscopic guidance, to the site of the lesion. The technique has been used without complication in more than 30 patients with cancer of the pancreas and bile ducts.

Bile Duct Neoplasms↗

Percutaneous subhepatic cholecystostomy with removable anchor.

Percutaneous subhepatic cholecystostomy is preferable to the transhepatic technique because it spares the liver from unnecessary trauma and possible sepsis. In order to prevent gallbladder wall invagination and intraperitoneal bile leakage, the fundus is first secured to the abdominal wall with a removable anchoring device that is introduced through a 17-gauge needle system under sonographic and fluoroscopic control. With this technique, the gallbladder was drained in seven patients with possible empyema, and stones were extracted from the gallbladder in three patients who were poor risks for cholecystectomy. None of the patients had hypotension, bile leakage, peritonitis, or bleeding. Subhepatic cholecystostomy was done safely in 10 patients after temporarily anchoring the fundus to the abdominal wall.

Aged↗

Transesophageal drainage of mediastinal abscesses.

Esophageal perforation with subsequent formation of a mediastinal abscess is a well-recognized clinical entity. Causes include perforation due to rigid and fiberoptic endoscopy, bouginage, breakdown of surgical anastomoses, and protracted vomiting. This disorder is associated with a high morbidity and, without intervention, a high mortality. In the past, surgery has been the treatment of choice. Although percutaneous drainage techniques have been used in some cases, they are frequently less attractive due to the location of the esophagus and its proximity to thoracic organs and vascular structures. In this study, eight abscesses caused by esophageal perforations were drained through a transesophageal route with minimal patient morbidity. These cases are presented with a discussion of the techniques and patient follow-up.

Abscess↗

Transcatheter embolization of hepatic arteriovenous fistula in Osler-Weber-Rendu disease--a case report.

Hereditary hemorrhagic telangiectasia (Osler-Weber-Rendu disease) is associated with arteriovenous fistulas throughout the body that can cause hemodynamic abnormalities. Owing to their size and extent, surgical repair is often not feasible. A patient referred for presumed valvular heart disease is described. On the basis of oximetry data at cardiac catheterization, a large intrahepatic arteriovenous fistula was discovered by aortography. This finding and a history of recurrent epistaxis were consistent with Osler-Weber-Rendu disease. Owing to the size of the fistula, embolization of the right hepatic artery with Gianturco coils was chosen as treatment, with resultant symptomatic improvement and decreased arteriovenous shunting.

Arteriovenous Fistula↗

Terminal deletion of the long arm of chromosome 10.

A de novo chromosome abnormality interpreted as a terminal deletion of chromosome 10, del(10)(pter----q25.2:), was ascertained in a newborn female with multiple malformations. The clinical features observed at birth and on follow up at 10 months of age are described and compared with previously reported cases.

Adolescent↗

Coagulation of aneurysms by direct percutaneous thrombin injection.

We describe a new technique for clotting aneurysms by direct injection of diluted thrombin through a fine needle or cannula. The four patients treated had pseudoaneurysms of the iliac, femoral, and peroneal arteries, and a true aneurysm of an accessory hepatic artery. Five hundred to one thousand (500-1000) units of thrombin were injected into the aneurysmal sac only when there was blood stasis, either de novo or induced by occlusion of the feeding vessel. No significant complications ensued.

Adolescent↗

Wettability of the corneal surface: a reappraisal.

Previous attempts by others to measure the wettability of the corneal epithelium concluded that the surface was strongly hydrophobic, but used methods which seem likely to damage the epithelial cell surface. These experimental techniques were repeated and the effects on the surface analysed by scanning electron microscopy. It is concluded that such methods cannot establish either the hydrophobicity or hydrophilicity of the cornea.

Animals↗

Minipuncture angiography.

The frequency of arterial trauma or hematoma can be reduced by using smaller puncturing needles (21-gauge) and catheters (4- or 5- French). Versatile ultrafine guide wires are now available for selective and superselective catheterization. This miniaturization of angiographic equipment allows many vascular procedures to be performed safely on an outpatient basis or in short procedure units.

Angiography↗

Failed hemodialysis shunts. One year of experience with aggressive treatment.

Thirty-three failed hemodialysis access shunts in 26 patients were treated by streptokinase declotting and/or transluminal angioplasty over a period of one year. Seventeen (52%) were restored to function without surgical intervention; 7 (21%) had restoration of flow but required surgical correction of an underlying problem such as a pseudoaneurysm or vascular stenosis which resisted angioplasty; and 9 (27%) showed no improvement. The authors discuss their technique as well as causes of shunt failure, those lesions likely to be improved by declotting and/or angioplasty, and reasons for treatment failure and recurrent thrombosis.

Angiography↗